Modulation Engineering of Graphitic/Pyrrolic Nitrogen Co-Doped Porous Carbon-Based Electrocatalysts with Abundant Active Sites for Efficient CO2 Reduction.

Developing metal-free catalysts is critical to addressing the issues of susceptibility to poisoning and deficient durability in the electrocatalysis of metal-based materials for CO2 reduction reaction (CO2RR). Herein, N-doped carbon nanoparticles (NCs) with a specific ratio of graphitic/pyrrolic N, high specific surface area, and abundant nanopores are synthesized by pyrolyzing a Cu and Zn co-coordinated polymer with bis(imino)-pyridine ligands. Results demonstrate that precise co-incorporation of Cu and Zn in the precursor effectively modulates the N doping species and ratios of NCs, as well as the pore structure, resulting in significantly distinct CO2RR behaviors.

Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective.

Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, and its dysbiosis is essentially correlated to tumorigenesis, cancer progression, and refractoriness to cancer treatments, including the novel immunotherapy. Increasing evidence unravel the intricate role of gut microbiota in reshaping tumor microenvironment and affecting the efficacy and toxicities of immunotherapy, which shed more light on the future applications of gut microbiota in efficacious biomarker and combination treatment of immunotherapy. To better grasp the underlying crosstalk between gut microbiota and immunotherapy, more experimental and clinical trials are indispensable for the customized gut microbiota-based treatments in cancer patients undergoing immunotherapy.

Natural Molecule-Derived Nanogels from Hematoxylin and l-lysine for Biomedical Use with Antimicrobial Properties.

Hematoxylin (HT) is a natural staining dye used in histopathology, often combined with Eosin for H&E staining. A poly(hematoxylin-co-l-lysine) (p(HT-co-l)) nanonetwork was synthesized through a one-step Mannich condensation reaction using formaldehyde as a linking agent. The resulting p(HT-co-l) nanogels had an average size of about 200 nm and exhibited a smooth surface and desirable functional groups such as -OH, -NH, and -COOH, as recognized by FT-IR analysis.

Atomically dispersed rare earth dysprosium-nitrogen-carbon for boosting oxygen reduction reaction.

Transition metal-nitrogen-carbon (MNC) based on 3d metal atoms as promising non-precious metal catalysts have been extensively exploited for oxygen reduction reaction (ORR), but MNC with 4f rare earth metals have been largely ignored, most likely due to their large atomic radii that are difficult to coordinate with N dopants using conventional precursors. Herein, atomically dispersed dysprosium-nitrogen-carbon (DyNC) nanosheets were developed via the pyrolysis of anitrogen-containing chelate compound of 2, 4, 6-Tri (2-pyridyl) 1, 3, 5-triazine (TPTZ) ligand with Dy under the assistance of molten NaCl. The as-synthesized DyNC features specific moieties of single Dy atom coordinated by N and O as active sites for ORR, displaying excellent performance.

Multi-classification of breast cancer pathology images based on a two-stage hybrid network.

Background And Objective: In current clinical medicine, pathological image diagnosis is the gold standard for cancer diagnosis. After pathologists determine whether breast lesions are malignant or benign, further sub-type classification is often necessary.

Methods: For this task, this study designed a multi-classification model for breast cancer pathological images based on a two-stage hybrid network.

Enhancing thermal transport of epoxy composites with vertically aligned graphene grown on the thermal interface.

The escalating demands for miniaturization, integration, and portability in electronic devices have underscored the criticality of efficient heat dissipation. The utilization of high-performance thermal interface materials (TIMs) to fill the gaps between contacting surfaces holds significant potential for enhancing heat transfer efficiency. Herein, we successfully enhance the thermal properties of the epoxy composite TIM by integrating grown vertically aligned graphene on the metal surface using radio frequency plasma-enhanced chemical vapor deposition (RF-PECVD).

Bio-MOFs Based on Natural Phenolic, Hematoxylin Leverages Biomedical Applications: Enzyme Inhibition, Antioxidant, and Antibacterial Properties.

Here, using natural hematoxylin (HT) as linker, metal-organic frameworks (MOFs) from Cu(II), Fe(II), and Fe(III) ions was prepared. The SEM images and DLS analyses revealed HT-based MOFs are View Article and Find Full Text PDF

Clinical value and risk factors of compression supporting screwsin patients with femoral neck fractures.

Background: This study was performed with attempt to explore the clinical value and risk factors of compression supporting screws for the treatment of femoral neck fractures.

Methods: This retrospective analysis enrolled 102 patients with femoral neck fractures who admitted to our hospital from June 2020 to June 2022. Based on different screws during the operation, the participants were allocated into hollow screw group (52 cases, conventional fixation of parallel partial-thread hollow screw) and compression screw group (50 cases, compression screw fixation).

The Role of Frustrated Lewis Pair in Catalytic Transfer Hydrogenation of Furfural using Nickel Single-Atom Catalysts: A Theoretical Study.

The burgeoning field of frustrated Lewis pair (FLP) heterogeneous catalysts has garnered significant interest in recent years, primarily due to their inherent ability to activate H-source molecules, thereby facilitating hydrogenation reactions. In this study, non-precious transition metal atoms were anchored onto several models of pyridinic nitrogen incorporated graphene sheet. Theoretical calculations substantiated energy barriers as low as 0.

Robust Distributed Learning Against Both Distributional Shifts and Byzantine Attacks.

In distributed learning systems, robustness threat may arise from two major sources. On the one hand, due to distributional shifts between training data and test data, the trained model could exhibit poor out-of-sample performance. On the other hand, a portion of working nodes might be subject to Byzantine attacks, which could invalidate the learning result.

FeO Nanoparticles Embedded into Pyridinic-N-Rich Carbon Nanohoneycomb with Strong Orbital Hybridization for High-Performance Electromagnetic Wave Absorption.

Carbon-based magnetic nanocomposites as promising lightweight electromagnetic wave (EMW) absorbents are expected to address critical issues caused by electromagnetic pollution. Herein, FeO nanoparticles embedded into a 3D N-rich porous carbon nanohoneycomb (FeO@NC) were developed via the pyrolysis of an in-situ-polymerized compound of m-phenylenediamine initiated by FeCl in the presence of NaCl crystals as templates. Results demonstrate that FeO@NC features highly dispersed FeO nanoparticles into an ultrahigh specific pyridinic-N doping carbon matrix, resulting in excellent impedance matching characteristics and electromagnetic wave absorbing capability with the biggest effective absorption bandwidth (EAB) of up to 7.

Clinical significance of immune-related antigen CD58 in gliomas and analysis of its potential core related gene clusters.

Background: The clinical significance of immune-related antigen in gliomas remains uncertain. The aim of this study was to examine the clinical importance and possible core related genes of CD58 in gliomas.

Methods: Pan-cancer analysis was to observe the association between and different tumors, glioma RNA sequencing data and clinical sample analyses were used to observe the relationship between and glioma, shRNA interference models were to observe the impact of on glioma cell function, and four glioma datasets and two online analysis platforms were used to explore the core related genes affecting the correlation between and glioma.

MiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway.

Micro RNAs (miRs) have been implicated in various tumorigenic processes. Osteosarcoma (OS) is a primary bone malignancy seen in adolescents. However, the mechanism of miRs in OS has not been fully demonstrated yet.

Gut microbial community and fecal metabolomic signatures in different types of osteoporosis animal models.

Background: The gut microbiota (GM) constitutes a critical factor in the maintenance of physiological homeostasis. Numerous studies have empirically demonstrated that the GM is closely associated with the onset and progression of osteoporosis (OP). Nevertheless, the characteristics of the GM and its metabolites related to different forms of OP are poorly understood.

Population structure, dispersion patterns and genetic diversity of two major invasive and commensal zoonotic disease hosts ( and ) from the southeastern coast of China.

The invasive brownrat () and the Oriental rats () are common commensal murid that are important hosts for rodent-borne diseases in southeast Asia. Understanding their population structure and genetic diversity is essential to uncover their invasion biology and distribution dynamics that are essential for controlling rodent-borne diseases. TA total of 103 and 85 were collected from 13 to 9 coastal areas of six provincial monitoring sentinel sites, respectivelyto assess patterns in their microsatellite loci and their mitochondrial coxl gene region.

Cisplatin and doxorubicin chemotherapy alters gut microbiota in a murine osteosarcoma model.

The gut microbiota is closely associated with tumor progression and treatment in a variety of cancers. However, the alteration of the gut microbiota during the progression and chemotherapy of osteosarcoma remains poorly understood. This study aimed to explore the relationship between dysbiosis in the gut microbiota during osteosarcoma growth and chemotherapy treatment.

Clinical characteristics of malignant germ cell tumors in adolescents: A multicenter 10-year retrospective study in Beijing.

Background: The aim of this study was to review clinical features of adolescent malignant germ cell tumors (MGCTs) in Beijing and analyze the peculiar characteristics of this age group.

Methods: Clinical characteristics, pathological presentations, and survival outcomes of 34 patients were analyzed retrospectively.

Results: Of 34 patients, 12 girls and 22 boys, 18 (52.

Prognostic factors for intermediate- or high-risk neuroblastomas in children in China.

Background: Evidence regarding the characteristics and prognosis of neuroblastoma (NBL) in China is limited. We aimed to investigate the characteristics and prognosis of intermediate- or high-risk NBL in children in China.

Methods: We included 147 patients with intermediate- or high-risk NBL evaluated from January 2006 to March 2015.

Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: a systematic review and network meta-analysis.

Objective: There are many injectable treatments for knee osteoarthritis with different characteristics and effects, the aim is to understand which one can lead to better and safer results.

Methods: The PRISMA principles were followed when doing the literature search. Web of Science databases, Embase, the Cochrane Library, PubMed, and the Wanfang database were searched to identified randomized controlled trials that assessed the efficacy of corticosteroids (CSC), platelet-rich plasma (PRP), hyaluronic acid (HA), and combination therapy in treating KOA.

Causal associations between gut microbiota, gut microbiota-derived metabolites, and cerebrovascular diseases: a multivariable Mendelian randomization study.

Background: Mounting evidence has demonstrated the associations between gut microbiota, gut microbiota-derived metabolites, and cerebrovascular diseases (CVDs). The major categories of CVD are ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). However, the causal relationship is still unclear.