Sodium alginate-based nanocomposite hydrogel membrane for removal of heavy metal ions and dyes in water.

Membrane filtration technology plays a crucial role in the field of water treatment because of its efficient separation and purification capability. However, it remains a major challenge to develop reusable membranes with high retention, stable filtration to remove heavy metal ions and dyes from water in the field. In this study, sodium alginate (SA), cellulose nanofibers (CNF) and metal-organic frame UiO-66 were innovatively used as raw materials to prepare SA/CNF/UiO-66 dual-network composite hydrogel membrane by unique cooking method.

Effortless Fabrication of Nanofused HKUST-1 for Enhanced Catalytic Efficiency in the Cyanosilylation of Aldehyd.

HKUST-1 (HKUST = Hong Kong University of Science and Technology) is one of the most recognized metal-organic frameworks (MOFs) based on copper and trimesate, extensively studied for a variety of applications, such as gas storage, separation, adsorption, electrocatalysis, drug delivery, sensor and photodegradation, etc. In this work, we introduce a novel nanofused HKUST-1, referred to as N-CuBTC (BTC = trimesate), which has been synthesized with the hydrothermal method at room temperature (typical synthesis temperature is from 80~120 °C). The resulting N-CuBTC features an irregular particle morphology, with numerous crystals clustering together and edges that have fused, creating a hierarchical pore structure.

Single-cell profiling and clinical characteristics analysis of lung squamous carcinoma.

Lung squamous carcinoma (LUSC) is a highly heterogeneous disease. However, the tumor microenvironment (TME) landscape and clinical characteristics for LUSC have not yet been elucidated. To map the TME and clinical characteristics of LUSC, we performed single-cell RNA sequencing for 504 LUSC samples on basis of TCGA and Gene Expression Omnibus.

Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI.

Background: Aβ deposition in the brain does not necessarily lead to cognitive impairment, and that blood supply may have other unexplained regulatory effects on Aβ. Therefore, there appears to be a more complex relationship between blood supply, Aβ deposition, and cognitive impairment that warrants further exploration.

Methods: This cohort study collected four longitudinal follow-up datasets, including a total of 281 subjects, followed for four years.

A high-efficiency oil/water emulsion separation sponge based on sodium alginate-loofah composite gels.

Nowadays, many reported oil/water (O/W) emulsion filter materials have issues such as susceptibility to fouling, complex processing, high costs, and environmental unfriendliness. Herein, a novel O/W emulsion separation membrane-like sponge (SA/GO-SL) is prepared in this study by utilizing reshaped waste loofah (LF) as skeleton, the in situ formed sodium alginate (SA) gels as binder, and the graphene oxide (GO) added into the gels as functional component. Reshaped LF provides an enough anti-pressure ability and micron-sized pores structure, which guarantees a water flux of 63.

[Effect of different filters on the efficacy in patients with sepsis-associated acute kidney injury].

Objective: To investigate the effects of using different filters in continuous renal replacement therapy (CRRT) on the mortality, inflammatory mediator level and hemodynamics in patients with sepsis-associated acute kidney injury (SA-AKI).

Methods: A prospective study was conducted. The patients with SA-AKI undergoing first CRRT admitted to the critical care medicine department of General Hospital of Ningxia Medical University from August 2022 to October 2023 were enrolled as the study objects, and they were divided into observation group and control group by random number table method.

Revealing the non-enzymatic covalent interaction between neo-/crypto-chlorogenic acid and beta-lactoglobulin under nonthermal process and potential delivery capability.

Several studies have shown that the protein-chlorogenic acid covalent complex has better function and stability than the non-covalent. The degree of binding between the proteins and chlorogenic acids (CQA) can be enhanced by the ultrasound process. Herein, the effects of ultrasound-assisted non-enzymatic covalent binding (the free radical induction (Vc)-ultrasound combination and the alkali treatment (Alkali)-ultrasound combination) of two chlorogenic acids (neochlorogenic acid (3-CQA), cryptochlorogenic acid (4-CQA)) and β-lactoglobulin (β-LG) on proteins structure and properties were investigated.

The microbiome- and metabolome-modulating activity of dietary cholesterol: insights from the small and large intestines.

Cholesterol is an important lipid molecule that affects the gut microbiome upon ingestion. We systematically investigated the effects of cholesterol on the microbiota of the large and small intestines using and models, combining flow cytometry, metabolomics, and metagenomics. The results showed that cholesterol directly causes a loss of bacterial membrane polarity and integrity, as well as a reduction in microbial metabolic activity.

Pharmacokinetics and bioequivalence of a molnupiravir tablet formulation compared with the molnupiravir capsule formulation in healthy adult participants-a randomized, open-label, three-period, crossover study.

Molnupiravir, a prodrug of β-D-N-hydroxycytidine (NHC), is administered orally as four 200 mg capsules twice daily for 5 days to treat COVID-19. This randomized, open-label, four-treatment sequence, three-period crossover study (NCT06615869) evaluated the bioequivalence of a new single 400 mg oral dose of the molnupiravir tablet Formulation 1 (F1) to a 400 mg oral dose of the currently authorized molnupiravir capsule formulation (administered as two 200 mg capsules) by comparing the plasma pharmacokinetics of NHC following administration to healthy participants. The effect of food on the plasma NHC pharmacokinetics following the administration of the molnupiravir F1 tablet, safety and tolerability of a single oral 400 mg dose of molnupiravir, and pharmacokinetics of a separate molnupiravir tablet Formulation 2 (F2) with a slower dissolution rate were also evaluated.

Serum Immune-Response Protein Biomarkers Based on Olink Technology for Diagnosis of Ischemic Stroke.

The immune response plays a crucial role in the treatment of ischemic stroke (IS). Our primary objective was to explore immune proteins related to stroke and to develop a noninvasive diagnostic panel. We used the high-throughput Olink immunoassay platform to quantitatively measure 92 proteins in the serum of 88 patients with IS and 88 controls.

Exploring the Mechanism of Surface Cationic Vacancy Induces High Activity of Metastable Lattice Oxygen in Li- and Mn-Rich Cathode Materials.

Li- and Mn-rich layered oxides exhibit high specific capacity due to the cationic and anionic reaction process during high-voltage cycling (≥4.6 V). However, they face challenges such as low initial coulombic efficiency (~70 %) and poor cycling stability.

Suppression of METTL3 expression attenuated matrix stiffness-induced vaginal fibroblast-to-myofibroblast differentiation and abnormal modulation of the extracellular matrix in pelvic organ prolapse.

Background: Fibrosis of the connective tissue in the vaginal wall predominates in pelvic organ prolapse (POP), which is characterized by excessive fibroblast-to-myofibroblast differentiation and abnormal deposition of the extracellular matrix (ECM). Our study aimed to investigate the effect of ECM stiffness on vaginal fibroblasts and to explore the role of methyltransferase 3 (METTL3) in the development of POP.

Methods: Polyacrylamide hydrogels were applied to create an ECM microenvironment with variable stiffness to evaluate the effects of ECM stiffness on the proliferation, differentiation, and expression of ECM components in vaginal fibroblasts.

The clinical characteristics and prognosis of surgically treated ovarian endometrioma in pregnant women.

Purpose: To investigate the clinical characteristics and prognosis of surgically treated ovarian endometrioma (OMA) in pregnant women.

Methods: This retrospective cohort study analyzed 30 patients with pathologically confirmed ovarian endometrioma during pregnancy and delivery. Clinical characteristics and follow-up data were summarized.

Gut microbiota and inflammasome-mediated pyroptosis: a bibliometric analysis from 2014 to 2023.

Background: The role of gut microbiota in inflammatory disease development and progression has been recognized more recently. Inflammasome-mediated pyroptosis in involved in these diseases. This complex relationship between gut microbiota and inflammasome-mediated pyroptosis provides an important field of research.

Appendectomy and the risk of microscopic colitis - A systematic review and meta-analysis.

Background: Microscopic colitis (MC), a chronic intestinal inflammatory disorder characterised by persistent watery diarrhoea, is categorised into collagenous and lymphocytic subtypes. Recent studies suggest that appendectomy influences the risk of MC, although the evidence remains inconclusive. This meta-analysis of available research was conducted to clarify the relationship between appendectomy and MC risk.

Unraveling the controversy: exploring the link between sex hormones and skin cancers through a meta-analysis and systematic review.

Skin cancers continue to present unresolved challenges, particularly regarding the association with sex hormones, which remains a topic of controversy. A systematic review is currently warranted to address these issues. To analyze if sex hormones result in a higher incidence of skin cancers (cutaneous melanoma, basal cell carcinoma, squamous cell carcinoma).

Multifunctional metal-organic frameworks with photothermal-triggered nitric oxide release for gas/photothermal synergistic cancer therapy.

Photothermal therapy (PTT) utilizing cyanine dyes (Cy) and nitric oxide (NO) gas therapy via BNN6 have demonstrated significant potential in cancer treatment. However, the rapid clearance of these small molecules from the body limits their accumulation at tumor sites, thereby reducing therapeutic efficacy. To address this, we employed the acid-sensitive nanomaterial ZIF-8 as a carrier to encapsulate Cy and BNN6, creating functionalized BNN6-Cy@ZIF-8 Nanoparticles (B-C@Z NPs) for the targeted delivery and release of Cy and BNN6 at tumor sites.

The gut microbiota-SCFA-inflammation axis in patients with AECOPD.

Objectives: The aim of the study was to explore the alteration of microbiota and SCFA in gut and inflammation in acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients, and to test the hypothesis that a disorder of gut microbiota will lead to the alteration of SCFA, which will aggravate inflammation in AECOPD patients.

Methods And Results: 24 patients with AECOPD and 18 healthy volunteers were included in the study. Gut microbiota were analyzed by 16S rDNA and serum was used to detect levels of inflammatory factors by ELISA.

Selective inhibition of HSF1 expression in the heat shock pathway of keloid fibroblasts reduces excessive fibrosis in keloid.

The stress response following burns may be a crucial factor in keloid formation, yet the underlying pathological mechanisms remain to be elucidated. This study initially investigated how heat shock factor 1 (HSF1) and heat shock proteins (HSPs) within the heat shock pathway influence keloid fibrosis, providing insights into the role of the heat shock response in keloid development. This study aims to further elucidate the role of the heat shock pathway in keloid fibrosis and investigate the specific function of HSF1 within this pathway.

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection.

DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to express DS-Cav1, SC-TM, and DS2.

Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study.

Background: Ectopic pregnancy (EP) accounts for approximately 2% of all pregnancies, with tubal ectopic pregnancies (TEPs) being the most common type. Methotrexate (MTX) is a noninvasive and effective medical management option for TEP, but failure rates range from 10 to 36%, posing challenges in clinical practice. Identifying risk factors for MTX treatment failure is crucial to improve patient outcomes and guide clinical decision-making.

The comparison of the risk of neurological deterioration and clinical outcomes in different atherosclerotic stroke patterns.

This study aims to compare the incidences of neurological deterioration (ND) and poor outcome (a modified Ranking scale > 2 points at discharge) among patients with different atherosclerotic stroke patterns. A total of 688 participants were categorized into 4 groups according to atherosclerotic stroke pattern: multiple small infarcts (MSI), single subcortical infarction (SSI), borderzone infarct (BZI) and large infarct groups. Among the 4 groups, MSI group had the lowest incidences of ND and poor outcome (13.

The expression of glycolysis-related proteins in urine significantly increases after running.

Objective: Glucose metabolism is the main way in which cells obtain energy during exercise and plays an important role in exercise. The purpose of this study was to explore the changes in the expression of glucose metabolism-related proteins in urine after running, and finally applied to the monitoring of running training.

Methods: Urine samples were collected before and after running, and urine proteomics information was collected to explore the expression of proteins in the urine using LC-MS/MS in DDA mode and DIA mode.

Analysis of tracheal, bronchial, and lung cancer attributable to respiratory system-related risk factors in 204 countries and territories from 1990 to 2019.

Introduction: We analyzed trends in the tracheal, bronchial, and lung (TBL) cancer disease burdens attributable to respiratory system-related risk factors in 204 countries and territories from 1990 to 2019.

Material And Methods: Based on the results of the 2019 Global Burden of Disease study, we calculated and analyzed the estimated annual percentage changes (EAPCs) in the age-standardized disability-adjusted life year (DALY) rates and death rates of TBL cancer attributable to total and four individual risk factors globally, regionally, and nationally.

Results: From 1990 to 2019, the age-standardized DALY rate and death rate of TBL cancer only attributable to ambient particulate matter pollution increased globally, and in all Socio-Demographic Index (SDI) quintiles, except for high SDI quintiles.