[Analysis of Frequencies and Subsets of Peripheral Helper T Cells in Patients with Immune Thrombocytopenia].

Objective: To investigate the frequencies and subset distribution of peripheral helper (Tph) T cells in patients with immune thrombocytopenia (ITP), and explore the pathogenesis of ITP.

Methods: A total of 25 newly diagnosed ITP patients treated in The Second Affiliated Hospital of Dalian Medical University from January to December 2022 were selected, and 25 healthy volunteers (age- and sex-matched) were recruited as the control group. Flow cytometry was used to detect the subsets of CD4 T cells and Tph cells.

How lactate affects immune strategies in lymphoma.

Tumor cells undergo metabolic reprogramming through shared pathways, resulting in a hypoxic, acidic, and highly permeable internal tumor microenvironment (TME). Lactate, once only regarded as a waste product of glycolysis, has an inseparable dual role with tumor immunity. It can not only provide a carbon source for immune cells to enhance immunity but also help the immune escape through a variety of ways.

PDA@α-ZrP/SiO incorporated phosphate coating with enhanced corrosion resistance and friction resistance.

In this study, α-ZrP and SiO composite nanomaterials were used to as phosphating accelerators. Experiments show that 2D nanosheets and 0D nanoparticles modified by PDA (PDA@α-ZrP/SiO) play a synergistic role in effectively increasing the number of phosphate crystals and refining the crystal's size, thereby forming dense and uniform phosphate coatings. The friction resistance and corrosion resistance of phosphate coatings are simultaneously enhanced.

A novel telomere-related genes model for predicting prognosis and treatment responsiveness in diffuse large B-cell lymphoma.

Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous disease with diverse clinical and molecular features. Telomere maintenance is widely present in tumors, but there is a lack of relevant reports on the role of telomere-related genes (TRGs) in DLBCL. In this study, we used consensus clustering based on TRGs expression to identify two molecular clusters with distinct prognoses and immune cell infiltration.

Demulsifier-Inspired Superhydrophilic/Underwater Superoleophobic Membrane Modified with Polyoxypropylene Polyoxyethylene Block Polymer for Enhanced Oil/Water Separation Properties.

Demulsifiers are considered the key materials for oil/water separation. Various works in recent years have shown that demulsifiers with polyoxypropylen epolyoxyethylene branched structures possess better demulsification effects. In this work, inspired by the chemical structure of demulsifiers, a novel superhydrophilic/underwater superoleophobic membrane modified with a polyoxypropylene polyoxyethylene block polymer was fabricated for enhanced separation of O/W emulsion.

Entrepreneurial Capability, Career Development, and Entrepreneurial Intention: Evidence From China's HR Survey Data.

Based on 2018 China's Human Resource Employees Survey Data, this study uses the probit model to examine the impact of entrepreneurial ability and career development on HR's entrepreneurial intention. In terms of entrepreneurial ability, the results show that the educational background of Human Resource Management, cross-disciplinary knowledge, job-hopping experience, and the number of subordinates have significant positive impacts on HR's entrepreneurial intention. In terms of career development, lack of promotion space, skill upgrading opportunities, and lower than expected income have significant positive impacts on HR's entrepreneurial intention, and these impacts are heterogeneous among different enterprises.

Effects of HMGA2 on the epithelial-mesenchymal transition-related genes in ACHN renal cell carcinoma cells-derived xenografts in nude mice.

Background: The architectural transcriptional regulator high-mobility group AT-hook 2 (HMGA2) is an oncofetal protein which has been reported to be ectopically expressed in a variety of cancers. A high expression of HMGA2 in human renal cell carcinoma (RCC) is related with tumor invasiveness and poor prognosis. Recent in vitro studies have shown that HMGA2 knockdown was able to decrease cell proliferation and migration, and regulate the gene expression related to epithelial-mesenchymal transition (EMT).

Fabrication of Temperature- and Alcohol-Responsive Photonic Crystal Hydrogel and Its Application for Sustained Drug Release.

Herein, crack-free photonic crystal templates with enhanced color contrast were first demonstrated by the coassembly of polystyrene (PS) microspheres and graphene oxide (GO). Then, photonic crystal hydrogels (PCHs) with quick responses to temperature and alcohol solution concentration changes were fabricated by photopolymerization of monomers in the gaps of the self-assembled colloidal crystal templates. The structural color of the PCHs changed from yellow to blue within 120 s as the temperature rose from 25 to 40 °C, whereas upon a decrease in temperature from 40 to 25 °C, the structural color changed from blue to yellow.

Genetic Analysis and Targeted Therapy Using Buparlisib and MK2206 in a Patient with Triple Metachronous Cancers of the Kidney, Prostate, and Squamous Cell Carcinoma of the Lung: A Case Report.

Multiple primary cancers (MPC) occurring in the same individual is considered rare but being increasingly recognized owing to the longer cancer survival nowadays. Despite of accumulating experience in diagnosis, effective treatment remains to be problematic in many scenarios. Genetic testing-based targeted therapy could be an invaluable option for both diagnosis and treatment of such patients.

Optimization of microemulsion cleaning sludge conditions using response surface method.

Microemulsion cleaning method has been proved to be an effective way to clean oily sludge with low interfacial tension and high solubilizing ability for non-miscible liquids. In this paper, the percentage range of the microemulsion in the formulation was obtained by studying phase behavior of the microemulsion. The response surface method was used to model and optimize the microemulsion to obtain the best formulation: n-BuOH content at 9.

A dataset of distribution and diversity of ticks in China.

While tick-borne zoonoses, such as Lyme disease and tick-borne encephalitis, present an increasing global concern, knowledge of their vectors' distribution remains limited, especially for China. In this paper, we present the first comprehensive dataset of known tick species and their distributions in China, derived from peer-reviewed literature published between 1960 and 2017. We searched for journal articles, conference papers and degree thesis published in both English and Chinese, extracted geographic information associated with tick occurrence, and applied quality-control procedures to remove duplicates and ensure accuracy.

Placental transfer of bromocriptine in an human placental perfusion model.

To determine the rate and extent of the maternal-fetal transplacental passage of bromocriptine (BCT) in the dually perfused human placental model. Twenty term placentas were included in an human placental perfusion experiment with a closed-circuit model. At the start of the perfusion, BCT at the concentration of 10 or 100 ng/ml along with 100 µg/ml antipyrine which used as a positive marker were added to the maternal reservoir.

Transplacental transfer of oseltamivir phosphate and its metabolite oseltamivir carboxylate using the ex vivo human placenta perfusion model in Chinese Hans population.

Objective: The objective of the study was to determine transplacental of oseltamivir phosphate (OP) and its active metabolite oseltamivir carboxylate (OC) using the ex vivo human placental perfusion model in Chinese Hans population.

Study Design: Perfusion studies were performed on 20 placentas from healthy term pregnancies. Concentrations typical for 75 mg, twice-daily oral dose were tested (OP 65.

Practice audits to reduce caesareans in a tertiary referral hospital in south-western China.

Objective: To assess the effectiveness of a three-stage intervention to reduce caesarean deliveries in a Chinese tertiary hospital.

Methods: A retrospective study was conducted to assess whether educating staff, educating patients and auditing surgeon practices (introduced in 2005) had reduced caesarean delivery rates. Multiple logistic regression was used to check for a potential association between caesarean rates and rates of admission to the neonatal intensive care unit (NICU).