Publications by authors named "Tian Yi Tang"
Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers.
Angew Chem Int Ed Engl
October 2022
Article Synopsis
- Catalytic asymmetric dynamic kinetic resolution is an emerging method for creating atropisomers, but its effectiveness is limited by the torsional strain of biaryl substrates.
- This study introduces a new reaction between biaryl thionolactones and activated isocyanides that is independent of torsional strain, enabling the synthesis of tri- and tetra-ortho-substituted thiazole-containing biaryls with high yields and enantioselectivities.
- The research also outlines how these compounds can be easily transformed into a new type of bridged biaryl with an eight-membered lactone, and includes mechanistic studies that explain the unique reactivity observed.
The appendices were incorrectly numbered in the original article. Please see below correcct appendices.
View Article and Find Full Text PDFIntroduction: Weight loss in cancer patients is a worrisome constitutional change predicting disease progression and shortened survival time. A logical approach to counter some of the weight loss is to provide nutritional support, administered through enteral nutrition (EN) or parenteral nutrition (PN). The aim of this paper was to update the original systematic review and meta-analysis previously published by Chow et al.
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