Electrochemical In Situ Characterization Techniques in the Field of Energy Conversion.

With the proposal of the "carbon peak and carbon neutrality" goals, the utilization of renewable energy sources such as solar energy, wind energy, and tidal energy has garnered increasing attention. Consequently, the development of corresponding energy conversion technologies has become a focal point. In this context, the demand for electrochemical in situ characterization techniques in the field of energy conversion is gradually increasing.

Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms.

Aging is a complex and universal process marked by gradual functional declines at the cellular and tissue levels, often leading to a range of aging-related diseases such as diabetes, cardiovascular diseases, and cancer. Delaying the aging process can help prevent, slow down, and alleviate the severity of these various conditions, enhancing overall health and well-being. Alpha-glucosidase inhibitors (AGIs) are a class of widely used antidiabetic drugs that inhibit alpha-glucosidase in the small intestinal mucosa, delaying carbohydrate absorption and reducing postprandial hyperglycemia.

Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production.

Background: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Sodium-glucose cotransporter protein 2 inhibitors (SGLT2i) are antihyperglycemic agents that provide additional renal-protective effects in patients with DKD, independent of their glucose-lowering effects. However, the underlying mechanism remains unclear.

Advances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase.

N-acetyltransferase 10 (NAT10) is a member of the Gcn5-related N-acetyltransferase (GNAT) family and it plays a crucial role in various cellular processes, such as regulation of cell mitosis, post-DNA damage response, autophagy and apoptosis regulation, ribosome biogenesis, RNA modification, and other related pathways through its intrinsic protein acetyltransferase and RNA acetyltransferase activities. Moreover, NAT10 is closely associated with the pathogenesis of tumors, Hutchinson-Gilford progeria syndrome (HGPS), systemic lupus erythematosus, pulmonary fibrosis, depression and host-pathogen interactions. In recent years, mRNA acetylation has emerged as a prominent focus of research due to its pivotal role in regulating RNA stability and translation.

Associations Between the Polymorphisms in the Coding Sequence of SLCO1B1 and Blood Lipid Levels Before and After Treatment by Atorvastatin in the Chinese Han Adults with Dyslipidemia.

Purpose: Atorvastatin is commonly used to treat dyslipidemia; however, individual responses vary considerably. This study endeavors to evaluate the relationship between polymorphisms in the coding sequence (CDS) of SLCO1B1 gene and blood lipid levels before and after atorvastatin treatment among the Chinese Han adults with dyslipidemia.

Patients And Methods: A total of 165 Chinese Han adults undergoing atorvastatin therapy were enrolled in this study and followed up quarterly.

GLP-1/GIP dual agonist tirzepatide normalizes diabetic nephropathy via PI3K/AKT mediated suppression of oxidative stress.

Background: Effective therapeutic approaches for the treatment of diabetic nephropathy (DN) with irreversible deterioration of renal function are currently lacking. In this study, we aimed to investigate the ability of the glucagon-likepeptide-1 (GLP-1)/ gastric inhibitory polypeptide (GIP) dual agonist, tirzepatide to alleviate DN in mice and its underlying mechanisms.

Methods: We investigated the reno-protective effect of semaglutide and tirzepatide in a mouse model of DN, an insulin-treated positive control group was also included.

Recurrence and influencing factors of hepatitis B surface antigen seroclearance induced by peginterferon alpha-based regimens.

Background: The long-term stability of hepatitis B surface antigen (HBsAg) seroclearance following peginterferon alpha (peg-IFN-α)-based therapy has not been extensively studied, leaving the full potential and limitations of this strategy unclear.

Aim: To assess HBsAg recurrence after seroclearance achieved by peg-IFN-α regimens.

Methods: This prospective, multicenter, observational study was conducted from November 2015 to June 2021 at three Chinese hospitals: The Second Affiliated Hospital of Xi'an Jiaotong University, Ankang Central Hospital, and The Affiliated Hospital of Yan'an University.

Experimental investigation on heat and moisture transfer of propylene glycol-mixed steam in porous media.

Propylene glycol (PG)-mixed steam enhanced extraction is a promising remediation technique for removing semi-volatile organic compounds (SVOCs) from the unsaturated zone. However, the mechanisms of heat and moisture transfer during PG-mixed steam injection remain unclear. In this study, a 2D experimental system was developed to enable non-invasive monitoring of the spatio-temporal distribution of temperature and degree of saturation during steam injection into porous media.

Unraveling the Intricacies of Curiosity: A Comprehensive Study of Its Measures in the Chinese Context.

Curiosity, as the strong desire to acquire new information, plays a crucial role in human behaviors. While recent research has delved into the effects, behavioral manifestations, and neural underpinnings of curiosity, the absence of standardized assessment tools for measuring curiosity may hinder advancements in this field. Here, we translated different curiosity scales into Chinese and tested each translated scale by examining its reliability and structural validity.

Ubiquitination and Metabolic Disease.

The increasing incidence of metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), in the past decade is a serious concern worldwide. Disruption of cellular protein homeostasis has been considered as a crucial contributor to the pathogenesis of metabolic diseases. To maintain protein homeostasis, cells have evolved multiple dynamic and self-regulating quality control processes to adapt new environmental conditions and prevent prolonged damage.

Efficacy and Safety of Intravenous Tenecteplase Before Endovascular Thrombectomy for Acute Ischemic Stroke: The Multicenter, Randomized, BRIDGE-TNK Trial Protocol.

Background: Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke. Tenecteplase, a recombinant human tenecteplase tissue-type plasminogen activator, is a genetically modified variant of alteplase. It is unclear whether the outcomes are different if alteplase is replaced with tenecteplase.

Percutaneous External Fixation of Redistributed Orbital Fat in Transcutaneous Lower Eyelid Blepharoplasty.

Background: While percutaneous external fixation has gained popularity in transconjunctival blepharoplasty due to its simplicity and minimal incision, internal fixation remains the standard approach in transcutaneous blepharoplasty.

Objectives: This study aims to assess the safety and effectiveness of percutaneous external fixation specifically in transcutaneous fat repositioning blepharoplasty.

Methods: From May 2022 to December 2023, a consecutive cohort of 97 patients underwent this surgical technique.

Evaluation of emotion classification schemes in social media text: an annotation-based approach.

Background: Emotion analysis of social media texts is an innovative method for gaining insight into the mental state of the public and understanding social phenomena. However, emotion is a complex psychological phenomenon, and there are various emotion classification schemes. Which one is suitable for textual emotion analysis?

Methods: We proposed a framework for evaluating emotion classification schemes based on manual annotation experiments.

Nitrate sources and transformation in surface water and groundwater in Huazhou District, Shaanxi, China: Integrated research using hydrochemistry, isotopes and MixSIAR model.

Global water resources affected by excessive nitrate (NO) have caused a series of human health and ecological problems. Therefore, identification of NO sources and transformations is of pivotal significance in the strategic governance of widespread NO contaminant. In this investigation, a combination of statistical analysis, chemical indicators, isotopes, and MixSIAR model approaches was adopted to reveal the hydrochemical factors affecting NO concentrations and quantify the contribution of each source to NO concentrations in surface water and groundwater.

Impact of stress hyperglycemia on outcomes in patients with large ischemic stroke.

Background: Clinical evidence of the potential influence of stress hyperglycemia ratio (SHR) for patients with large ischemic stroke whether or not receiving endovascular therapy is not clear.

Methods: This study was a subanalysis of a prospective, multicenter registry, and included 745 patients with large ischemic stroke across 38 centers in China. A total of 427 patients were included in this study, with 285 received endovascular therapy (EVT) and 142 received standard medical therapy (SMT).

MicroRNAs in diabetic macroangiopathy.

Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both genetic and environmental factors, through a multitude of underlying molecular mechanisms, contribute to the pathogenesis of diabetic macroangiopathy. MicroRNAs (miRNAs), a class of non-coding RNAs known for their functional diversity and expression specificity, are increasingly recognized for their roles in the initiation and progression of diabetes and diabetic macroangiopathy.