The use of artificial neural network algorithms to enhance tourism economic efficiency under information and communication technology.

With the rapid advancement of information and communication technologies, smart tourism has become a crucial means for improving the quality of tourism services and enhancing economic efficiency in the tourism sector. This work proposes an analysis method based on the artificial neural network to predict tourist behavior patterns through big data analysis, thereby optimizing the allocation of tourism resources. The work begins by collecting various data types, including basic visitor information, consumption records, and satisfaction evaluations, from a well-known smart tourism destination as research samples.

The prognosis prediction value of CD69+ CD8+ tissue-resident memory T cell as a novel indicator of pathologic complete response heterogeneity following different neoadjuvant therapy regimen in esophageal squamous cell carcinoma.

Background: Improving pathological complete response (pCR) rate is currently the main goal of neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma (LA-ESCC). However, improved pCR rates do not consistently translate into better prognosis, likely due to regimen-specific pCR heterogeneity. We investigated this heterogeneity and potential biomarkers between two common neoadjuvant regimens.

Real-world data on immunotherapy combined with chemotherapy in elderly patients with extensive-stage small cell lung cancer.

Background: Immunotherapy combined with chemotherapy has shown good results in the treatment of extensive-stage small cell lung cancer (ES-SCLC), but there are fewer clinical studies on elderly ES-SCLC patients. This study was aimed to evaluate the efficacy and safety of immunotherapy in combination with chemotherapy in elderly patients with ES-SCLC.

Methods: Elderly patients with ES-SCLC who were 70 years of age or older and were diagnosed at Shandong Cancer Hospital from May 20, 2020, to February 24, 2023, were included in this study.

An advanced cytosine base editor enabled the generation of cattle with a stop codon in the β-lactoglobulin gene.

β-Lactoglobulin (BLG) is an allergen present in milk that can induce an acute immune response in certain individuals. The successful use of cytosine base editors (CBEs) can introduce stop codons into premature mRNA, thereby generating animals with disrupted genes that negatively regulate target traits. In this study, we employed a CBE system to target the major milk allergen BLG in bovine embryos, mammary epithelial cells, and live cattle.

Laparoscopic versus open secondary hepatectomy treating postoperative regional recurrent hepatolithiasis: a multicenter real-world study.

Background: Hepatectomy is the primary treatment for regional hepatolithiasis, but recurrence rates range from 10 to 20%, often necessitating repeat surgery. Although laparoscopic hepatectomy has been widely adopted for recurrent hepatocellular carcinoma, its use in recurrent hepatolithiasis remains limited due to technical challenges, including severe adhesions, anatomical distortions, and increased risks of complications. No large-scale study has compared laparoscopic and open repeat hepatectomy for recurrent regional hepatolithiasis.

Antibacterial mechanism of lysine against Escherichia coli O157:H7, its action on lettuce and in reducing the severity of murine colitis.

The aim of the present study was to evaluate the mechanism of antimicrobial action of Lysine (Lys) against Escherichia coli (E. coli) O157:H7. Lys alters the permeability and morphology of bacterial cell membranes, leading to leakage of intracellular material.

Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma.

Background: Almost 90% of head and neck malignancies are malignant squamous cell cancers, making it the sixth most common malignancy in the developing countries, with an overall five-year overall survival rate about 40%-50%. Early diagnosis and treatment can bring a better prognosis. Fibroblast growth factor (FGF) is an important polypeptide in vivo.

Royal Jelly Acid Alleviates Diet-Induced Hyperlipidemia through Regulation of Oxidative Stress and Tryptophan Metabolism.

Royal jelly acid is a unique unsaturated fatty acid isolated from royal jelly. Recently, royal jelly acid was proposed to have potential therapeutic effects on hyperlipidemia. However, its effect on hyperlipidemia and the underlying molecular mechanism remains unclear.

Soybean β-conglycinin-debranched starch flexible nano-conjugates: Focus on formation mechanism and physicochemical characteristics.

This study developed soybean 7S globulin-debranched starch (DBS) nano-conjugates via glycation to investigate the impact of DBS on 7S's physicochemical properties and the effect of different globulin-to-starch ratios on the conjugates. The results showed that 7S-DBS nano-conjugates with a 5:1 ratio had the smallest particle size (189.92 nm), lowest PDI (0.

Multichannel high-saturation photodetection technology for a femtosecond pulse optical measurement system.

A femtosecond pulse downconverts broadband electromagnetic signals to the hundreds of MHz range, enabling fast measurement and enhancing electromagnetic monitoring efficiency. However, due to the high peak power of optical pulses, the received power of the detector is severely limited, and thus the sensitivity of the system is reduced. To address this problematic issue, this paper presents a multichannel parallel high-saturation optical power-balanced photodetection technique that uses parallel reception to enhance the detector's received power, thereby improving the signal-to-noise ratio (SNR) and system sensitivity.

Traffic signal active control method for short-distance intersections.

Aiming at the existing problems about the overflow prevention goal and the overall traffic efficiency guarantee being difficult to optimize at the same time in the signal control process of short-distance intersections scenario, this paper proposes a traffic signal active control method based on key state prediction. In order to construct the key state evolution trend of short-distance intersection scenarios, this paper proposes the concept of overflow index for short-distance road sections and designs the prediction method of overflow index. In order to perform fast computation and solution for the active control scheme, this paper builds a solution algorithm based on deep reinforcement learning and optimizes the problem of reward sparsity in the algorithm, which improves the ability of active control in terms of state space and reward function.

Ferroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease.

Introduction: Crohn's disease (CD) is a group of chronic transmural inflammation of gastrointestinal tract, which seriously harms the mental and physical health of adolescents. At present, there are still no specific markers that make the diagnosis of CD extremely difficult and poor prognosis. Iron deficiency is common in CD, yet the role of ferroptosis-related genes in CD has not been elucidated.

Encryption application of a fast stimulus-responsive hydrogen-bonded organic framework based on FRET.

A photochromic ionic hydrogen-bonded organic framework (iHOF-51) was synthesized by reacting organic carboxylic acids with amidinium salts. Fast, reversible, and high-contrast stimulus-responsive behavior anionic radical naphthalenediimide (NDI) is observed. iHOF-51exhibits time-dependent photochromism in the powder state and excellent photoluminescent properties based on the synergistic interaction of FRET and radical anions in the 1%-iHOF-51-PVA composite membrane.

Genome-wide association and selection studies reveal genomic insight into saline-alkali tolerance in rice.

Saline-alkali stress has detrimental effects on growth and development of rice (Oryza sativa L.). Domesticated rice cultivars with high saline-alkali tolerance (SAT) are essential for sustainable agriculture.

Spatial transcriptome and single-cell RNA sequencing reveal the molecular basis of cotton fiber initiation development.

Recent advances in single-cell transcriptomics have greatly expanded our knowledge of plant development and cellular responses. However, analyzing fiber cell differentiation in plants, particularly in cotton, remains a complex challenge. A spatial transcriptomic map of ovule from -1 DPA, 0 DPA, and 1 DPA in cotton was successfully constructed, which helps to explain the important role of sucrose synthesis and lipid metabolism during early fiber development.

Correction: Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review.

[This corrects the article DOI: 10.1039/D2RA06888E.].

Comprehensive analysis of the mitochondrial genome of emphasizing multichromosomal organization and repeat-mediated homologous recombination.

Background: is a perennial herb valued for both its ornamental and medicinal properties. Despite its significance, no comprehensive analysis of its mitochondrial genome has been previously reported. Plant mitochondrial genomes are known for their large size, structural complexity, and frequent recombination events.

Tumor gene expression signatures associated with outcome in large B-cell lymphoma treated with CD19-directed CAR T-cell therapy (axicabtagene ciloleucel).

Introduction: CAR T cell therapy provided transformative outcomes for patients with B-cell lymphoma; however, a large fraction of patients remains at risk for relapse, underlying the need to uncover mechanisms of resistance and predictive biomarkers. Herein, we leveraged the ZUMA-7 phase III randomized trial of relapsed/refractory large B-cell lymphoma (LBCL) patients treated with axicabtagene ciloleucel (axi-cel; CD19-targeting CAR T cells) to discover tumor gene expression signatures (GES) associated with outcome.

Methods: With tumor transcriptomics from 134 axi-cel patients, we employed multivariate penalized Cox models analyzing event-free survival (EFS), progression-free survival (PFS), and duration of response (DOR).

ATP8A1-translocated endosomal phosphatidylserine fine-tunes the multivesicular body formation and the endo-lysosomal traffic.

P4-ATPases are phospholipid flippases responsible for the transbilayer lipid asymmetry. ATP8A1, a P4-ATPase family member, has been reported to be involved in phosphatidylserine (PS) translocation at the Golgi network, early endosomes and recycling endosomes. However, the possible roles of the PS on late endosomes/lysosomes pathway and how they are regulated remain to be elucidated.

modulates somatic embryogenesis in Chinese chestnut ( Blume).

Chinese chestnut ( Blume) is distinguished by its remarkable nut quality and robustness against disease and environmental stressor. However, its somatic embryogenesis process is notably slow, presenting a significant bottleneck in its cultivation. This study focuses on the () (), a member of transcription factors gene family, known for its critical role in the somatic embryo development of Arabidopsis.

Cardiovascular disease-specific and all-cause mortality across socioeconomic status and lifestyles among patients with established cardiovascular disease in communities of China: data from a national population-based cohort.

Background: Evidence of socioeconomic status (SES)-related health inequality is scarce in patients with cardiovascular diseases (CVDs) who need both lifestyle change and medical care, particularly in developing countries.

Methods: The study employed a nationwide population-based cohort design, covering all 31 provinces of Chinese mainland from September 2014 to March 2021. Participants aged 35-75 years with self-reported CVD diagnoses were included.

Associations Between Personality Traits, Self-Efficacy and Complementary Feeding Behavior Among Infant Caregivers in Western Rural China.

The effects of psychological factors on complementary feeding behavior have been widely described, yet the mechanisms underlying the complex relationships among personality traits, self-efficacy, and complementary feeding behavior remain unclear. This cross-sectional study was conducted using a multi-stage cluster sampling process to select caregiver-child dyads in Western rural China. Personality traits, self-efficacy, and complementary feeding behavior were evaluated respectively.

Genomic characterization and antifungal properties of YF, a promising biocontrol agent against pathogen of codonopsis root rot.

Root rot, a destructive soil-borne disease, poses a significant threat to a wide range of economically important crops. Codonopsis, a high-value medicine plant, is particularly susceptible to substantial production losses caused by -induced root rot. In this study, we identified a promising biocontrol agent for codonopsis root rot, YF.

Gut microbiota therapy in gastrointestinal diseases.

The human gut microbiota, consisting of trillions of microorganisms, plays a crucial role in gastrointestinal (GI) health and disease. Dysbiosis, an imbalance in microbial composition, has been linked to a range of GI disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, and colorectal cancer. These conditions are influenced by the interactions between the gut microbiota, the host immune system, and the gut-brain axis.