The impact of SGLT2 inhibitors on dementia onset in patients with type 2 diabetes - A meta-analysis of cohort studies.

Introduction: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated neuroprotective effects and hold potential advantages in enhancing cognitive function. This study aims to clarify the association between SGLT2 inhibitors and the risk of dementia among individuals diagnosed with type 2 diabetes (T2D).

Methods: All cohort studies concerning the impact of SGLT2 inhibitors on dementia onset in patients with T2D were identified.

Relic DNA obscures bacterial diversity and interactions in ballast tank sediment.

The dark and anoxic environment of ballast tank sediment (BTS) harbors substantial amounts of relic DNA, yet its impact on microbial diversity estimates in BTS management remains poorly understood. This study employed propidium monoazide (PMA) treatment to eliminate relic DNA and used 16S amplicon high-throughput sequencing to characterize both total and viable bacteria. Our findings revealed that relic DNA is abundant in BTS.

[Adverse Effects and Underlying Mechanisms of Soil Microplastics on Crops and Its Preventive Strategies].

Microplastics （MPs）, as a type of emerging environmental pollutant with a particle size < 5 mm, have been frequently detected in environmental matrices. MPs pollution in soils has been attracting the scientific community due to the increasing contaminant areas and continuous accumulation, leading to a high risk to crop production. In addition, recent studies have observed that long-term exposure to MPs could seriously harm the soil ecosystem because of their fine particle size and persistence in soils.

SNRNP70 regulates the splicing of CD55 to promote osteosarcoma progression.

Osteosarcoma (OS) is the most common malignant bone tumor, characterized by a high propensity for metastasis. Recent studies have highlighted the role of alternative splicing in cancer metastasis, although the precise mechanisms underlying aberrant splicing in OS invasion and metastasis remain unclear. Here, we analyzed consistently differentially expressed genes and differentially alternative splicing events between primary and metastatic OS to identify potential genes associated with OS progression.

N-methyladenosine on the natural antisense transcript of NIA1 stabilizes its mRNA to boost NO biosynthesis and modulate stomatal movement.

Nitric oxide (NO) is a crucial signaling molecule that regulates a wide range of metabolic pathways in different strata of organisms. In plants, nitrate reductase (NR) is a key enzyme for NO biosynthesis. There are two NR-encoding genes in Arabidopsis genome, NIA1 and NIA2, which are precisely regulated and expressed in a tissue-specific manner.

Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk.

Objectives: This study aimed to address the lack of gene expression regulation data in synovial tissues and to identify conditionally independent genes associated with rheumatoid arthritis (RA) in the synovium, a primary target tissue for RA.

Methods: Gene expression prediction models were built for synovial tissue using matched genotype and gene expression data from 202 subjects. Using this model, we conducted transcriptome-wide association study (TWAS), utilizing the largest RA genome-wide association study (GWAS) meta-analysis data (n = 276 020).

A hierarchical WC/NiCoW hollow nanotube array as a highly efficient electrocatalyst for hydrogen evolution.

The hydrogen evolution reaction (HER) holds great potential for sustainable hydrogen production but developing efficient and cost-effective electrocatalysts remains challenging. Here, we report the synthesis of a hierarchical WC/NiCoW hollow nanotube array electrocatalyst, featuring rapid gas release to minimize bubble aggregation and reaction retardation. Mechanistic insights into the HER kinetics reveal enhanced electron transfer at the WC-NiCoW interface and an accelerated Volmer step.

Exploring exosomes: novel diagnostic and therapeutic frontiers in thyroid cancer.

In recent years, the incidence of thyroid cancer has surged globally, posing significant challenges in its diagnosis, treatment, and prognosis. Exosomes, as a class of extracellular vesicles, are secreted by nearly all cell types and encapsulate a variety of nucleic acids and proteins reflective of their cell of origin, thereby facilitating critical intercellular communication. Recent advancements in understanding these exosomes have catalyzed their application in oncology, particularly through uncovering their roles in the pathogenesis, diagnosis, and therapy of cancers.

Enhanced Adsorption Kinetics and Capacity of a Stable CeF@NiN Heterostructure for Methanol Electro-Reforming Coupled with Hydrogen Production.

Alkaline methanol-water electrolysis system is regarded as an appealing strategy for electro-reforming methanol into formate and producing hydrogen with low energy-consumption compared with alkaline water electrolysis. However, stability and selectivity under high current densities for practical application remain challenging. Herein, a CeF@NiN nanosheets array anchored on carbon cloth (CeF@NiN/CC) was fabricated.

Identification and Mining of Functional Components of Polyphenols in Fruits of Germplasm Resources Based on Multivariate Analysis.

Polyphenols are important functional components that have anti-cancer and anti-inflammatory effects. Apple fruit is rich in polyphenols and is one of the dietary sources of polyphenols. The polyphenol components and contents of the peel and pulp of 74 (Led.

Optimal QT Correction Formula for Older Chinese: Guangzhou Biobank Cohort Study.

Introduction: To identify the optimal QT correction formula for generating corrected QT (QTc) and cutoffs for prolonged QTc, and examine the associations with mortality and cardiovascular disease (CVD) in older Chinese.

Methods: A prospective study included 24,611 Chinese aged 50+ years and without CVD at 2003-2008 from Guangzhou Biobank Cohort Study. QT interval was corrected by Bazett, Fridericia, Framingham and Hodges formulas.

Environmental RNA metabarcoding for ballast water microbial diversity: Minimizing false positives.

While maritime transport boosts global trade by shipping bulk goods, it raises concerns about the spread of harmful bacteria via ballast water. Moreover, the dark and cold environments of ballast tanks often harbor extracellular DNA from dead organisms, leading to false positives in traditional environmental DNA (eDNA) metabarcoding analyses. Here, we alternatively employed environmental RNA (eRNA) metabarcoding to assess its potential for reducing false positive in ballast water monitoring.

Enhancing Sensitivity in Detecting Severe Fever With Thrombocytopenia Syndrome Virus: Development of a Reverse Transcription-Droplet Digital Polymerase Chain Reaction.

Severe fever with thrombocytopenia syndrome (SFTS) is a highly fatal disease. Droplet digital polymerase chain reaction (ddPCR) presents unparalleled sensitivity and enables absolute quantification of viral load. In this prospective study, we enrolled 111 patients with SFTS and collected 259 continuous samples.

Synergistic Gradient Anodes for Long-Term Stability in Aqueous Zinc-Ion Batteries.

The stability of aqueous zinc metal anodes is still constrained by their severe dendrite growth. Optimizing electric field distribution and crystallography to modulate the diffusion and deposition behavior of zinc ions can effectively suppress dendrite growth. However, the fabrication strategy to directly endow specific textured zinc anodes with gradient electric field distribution is still lacking.

Analysis of Aroma Characteristics of 'Binzi' and 'Xiangguo' Apple-Ancient Cultivars in China.

'Binzi' (BZ) ( subsp. var. Li Y.

Epigenetic modifications in hematopoietic ecosystem: a key tuner from homeostasis to acute myeloid leukemia.

Hematopoietic stem cells (HSCs) maintain homeostasis in the hematopoietic ecosystem, which is tightly regulated at multiple layers. Acute myeloid leukemia (AML) is a severe hematologic malignancy driven by genetic and epigenetic changes that lead to the transformation of leukemia stem cells (LSCs). Since somatic mutations in DNA methylation-related genes frequently occur in AML, DNA methylation is widely altered and functions as a starting engine for initiating AML.