ALDH1L2 drives HCC progression through TAM polarization.

Background & Aims: Dysregulation of one-carbon metabolism is considered an early hallmark of mitochondrial dysfunction and cancer metabolism. ALDH1L2 belongs to the aldehyde dehydrogenase family and plays an important role in tumor progression. However, little is known about the precise role and underlying mechanisms of ALDH1L2 in hepatocellular carcinoma (HCC).

Morphometric and phylogenetic analysis of a commercial fish (Teleostei, Leiognathidae).

The complete mitochondrial genome and phylogenetic analysis for from the South China Sea was performed using shallow genome skimming. For accurate species identification and redescription, morphometric and meristic characters were examined and compared with previous descriptions. To facilitate the identification of species and to enable comparison with the mitochondrial genome phylogeny, molecular comparisons were conducted using three mitochondrial genes: large ribosomal RNA ( rRNA), cytochrome c oxidase subunit 1 (), and NADH dehydrogenase ().

The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone-mediated autophagy.

There are three distinct forms of autophagy, namely, macroautophagy, microautophagy, and HSPA8 chaperone-mediated autophagy (CMA). While macroautophagy is widely recognized as a regulator of chromosomal instability (CIN) through various pathways, the contributions of CMA and microautophagy to CIN remain uncertain. , a conserved gene in vertebrates, is frequently mutated and down-regulated in numerous human cancers.

Temporal variation of soil phosphorus fractions and nutrient stoichiometry during wetland restoration: Implications for phosphorus management.

Wetland restoration can promote the recovery of ecosystem services. However, an increasing number of reports indicate that phosphorus leaching risk occurs in downstream water bodies during the early stages of agricultural utilized wetland restoration, it is unclear that whether this phenomenon depend on temporal dynamics. Therefore, in this study, we used soil phosphorus fractions and stoichiometry as indicators to investigate soil phosphorus leaching and examine their evolution during both short- and long-term wetland restoration, aiming to identify the key driving factors.

Association of tea consumption with life expectancy in US adults.

Objective: The association of tea consumption with life expectancy in US adults remains unclear. This study aimed to evaluate the correlation between tea consumption and life expectancy among US adults.

Methods: Tea consumption records and available mortality data from National Health and Nutrition Examination Survey 2001 to 2018 for adults ≥ 20 years of age were used (n = 43,276).

Serum Irisin as a Predictor for Peripheral Arterial Disease: Insights from a Clinical Study.

Objective: The purpose of this study was to investigate the correlation between serum irisin concentration and peripheral arterial disease (PAD), and to establish clinical prediction nomograms for PAD occurrence by comparing and analyzing clinical data from patients with PAD and healthy controls.

Methods: A total of 112 patients with PAD and 90 healthy individuals were recruited for the study. Clinical data from both groups were collected and serum irisin concentration was measured using enzyme-linked immunosorbent assay (ELISA).

Utilizing alternative in vivo animal models for food safety and toxicity: A focus on thermal process contaminant acrylamide.

Rodent models have traditionally been used to assess the toxicity of food chemicals, but this approach is costly, time-consuming, and raises ethical concerns. Alternatively, non-mammalian models such as Drosophila melanogaster, Danio rerio, and Caenorhabditis elegans have been shown to be suitable for studying the toxicity of food hazards. Their advantages include low cost, short life cycles, adaptability to high-throughput screening, and adherence to the 3R principles of replacement, reduction, and refinement.

The Full-Length Genomic Sequence of the HLA-B*39:130 Allele.

HLA-B*39:130 differs from HLA-B*39:01:01:01 at codon 214 (ACA → ATA) and position 355 (T → C) in intron 5.

The Dynamic Diversity and Invariance of Ab Initio Water.

Comprehending water dynamics is crucial in various fields, such as water desalination, ion separation, electrocatalysis, and biochemical processes. While ab initio molecular dynamics (AIMD) accurately portray water's structure, computing its dynamic properties over nanosecond time scales proves cost-prohibitive. This study employs machine learning potentials (MLPs) to accurately determine the dynamic properties of liquid water with ab initio accuracy.

Light-assisted functionalization of aryl radicals towards metal-free cross-coupling.

The many synthetic possibilities that arise when using radical intermediates, in place of their polar counterparts, make contemporary radical chemistry research an exhilarating field. The introduction of photocatalysis has helped tame aryl radicals, leading to a resurgence of interest in their chemistry, and an expansion of viable coupling partners and attainable transformations. These methods are more selective and safer than classical approaches, and they utilize new radical precursors.

Mediating role of resilience on burnout to well-being for hospital nursing staff in Northeast China: a cross-sectional study.

Objectives: The well-being of nursing staff is closely related to nursing performance and patient safety. It has attracted much attention from nursing managers and researchers. However, the most important influencing factors and their relationships are not fully understood.

Discovery and optimization of anthraquinone derivatives containing substituted bisbenzyloxy groups as a novel scaffold damaged endoplasmic reticulum and against hepatocellular carcinoma cells.

This paper reports the antitumor activity and possible mechanism of anthraquinone derivatives containing substituted bisbenzyloxy groups. Series of anthraquinone derivatives containing substituted bisbenzyloxy groups were designed and synthesized by etherification and esterification. The antitumor activities of the synthesized substituted bisbenzyloxy anthraquinone derivatives on liver cancer cell Huh7, triple negative breast cancer cell line MDA-MB-231 and lung cancer cell A549 were in the order of methoxy substitution > methyl substitution > chloral substitution.

Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin.

Purpose: Hepatocellular carcinoma (HCC) represents a significant global health problem, requiring precise prognostic tools for optimal treatment stratification. This study aimed to develop a new risk prediction score, called AD score, based on the serum markers alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), to offer an objective and accurate preoperative assessment of HCC in patients undergoing transarterial chemoembolization (TACE).

Patients And Methods: This was a retrospective study that included 295 HCC patients who were subjected to TACE (training set, n=147; testing set, n=148).

Development of a Compact NDIR CO Gas Sensor for a Portable Gas Analyzer.

A carbon dioxide (CO) gas sensor based on non-dispersive infrared (NDIR) technology has been developed and is suitable for use in portable devices for high-precision CO detection. The NDIR gas sensor comprises a MEMS infrared emitter, a MEMS thermopile detector with an integrated optical filter, and a compact gas cell with high optical coupling efficiency. A dual-ellipsoid mirror optical system was designed, and based on optical simulation analysis, the structure of the dual-ellipsoid reflective gas chamber was designed and optimized, achieving a coupling efficiency of up to 54%.