Publications by authors named "Tian T Wu"
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints.
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- The study investigates how autophagy affects the differentiation and migration of dental pulp stem cells (DPSCs) when treated with the iron chelator deferoxamine (DFO).
- DFO was found to enhance the autophagic activity in DPSCs, leading to increased mineralization and improved stem cell functions.
- The research suggests that the effects of DFO are partly driven by a pathway involving hypoxia-inducible factors and reactive oxygen species (ROS), highlighting the role of autophagy in stem cell behavior.