Yi-qi-yang-yin decoction ameliorates diabetic retinopathy: New and comprehensive evidence from network pharmacology, machine learning, molecular docking and molecular biology experiment.

Yi-Qi-Yang-Yin Decoction (YQYY), a traditional Chinese medicine (TCM) formula, has been used to treat diabetic retinopathy (DR), yet its precise mechanisms of action remain poorly understood. In this study, two distinct diabetic models, namely spontaneous type 2 diabetic db/db mice and streptozotocin (STZ)-induced type 1 diabetic rats, were employed to assess the efficacy of YQYY in ameliorating DR. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was employed to identify the chemical composition of YQYY in mouse serum.

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.

Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood. Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury.

LLMER: Crafting Interactive Extended Reality Worlds with JSON Data Generated by Large Language Models.

The integration of Large Language Models (LLMs) like GPT-4 with Extended Reality (XR) technologies offers the potential to build truly immersive XR environments that interact with human users through natural language, e.g., generating and animating 3D scenes from audio inputs.

Fine-Grained Spatial-Frequency-Time Framework for Motor Imagery Brain-Computer Interface.

The Motor Imagery Brain-Computer Interfaces (MI-BCIs) have shown considerable promise for applications in neural rehabilitation. However, improving the practicality and interpretability of MI-BCIs remains a critical challenge. Unlike previous methods that focus generally on either spatial, frequency, or temporal domains with coarse-grained segmentation schemes, this study proposes a novel fine-grained spatialfrequency- time (FGSFT) framework, aiming to enhance the efficiency and reliability of MI-BCIs.

Exploiting instance-label dynamics through reciprocal anchored contrastive learning for few-shot relation extraction.

In the domain of Few-shot Relation Extraction (FSRE), the primary objective is to distill relational facts from limited labeled datasets. This task has recently witnessed significant advancements through the integration of Pre-trained Language Models (PLMs) within a supervised contrastive learning schema, which effectively leverages the dynamics between instance and label information. Despite these advancements, the comprehensive utilization of extensive instance-label pairs, aimed at facilitating the extraction of semantically rich representations within this paradigm, has yet to be fully harnessed.

Global disease burden of breast cancer attributable to high fasting plasma glucose: a comprehensive analysis from the global burden of disease study.

Background: High fasting plasma glucose (HFPG) has been identified as one of the risk factors associated with the development of breast cancer. The worldwide distribution of breast cancer attributable to HFPG was not comprehensively investigated.

Methods: We utilized the data from the Global Burden of Disease Study 2021 to explore HFPG-related breast cancer deaths, disability adjusted life years (DALYs) and corresponding age-standardized rates (ASRs).

Comparing the efficacy and safety of thromboprophylaxis with enoxaparin versus normal saline after liver transplantation: randomized clinical trial.

Background: Venous thrombosis represents a significant complication after deceased-donor liver transplantation, yet there are currently no established protocols for thromboprophylaxis after deceased-donor liver transplantation. The aim of this study was to evaluate the efficacy and safety of prophylactic anticoagulation in patients undergoing deceased-donor liver transplantation.

Methods: A dual-centre RCT of patients assigned to receive either enoxaparin or normal saline after liver transplantation was conducted.

The miR-451a facilitates natural killer cell-associated immune deficiency after ischemic stroke.

Ischemic stroke is a devastating neurological disease. Brain ischemia impairs systemic immune responses and heightens susceptibility to infections, though the underlying mechanisms remain incompletely understood. Natural killer (NK) cells exhibited decreased frequency and compromised function after acute stage of stroke, resulting in NK cell-associated immune deficiency and increased risk of infection.

The role of lactylation in tumor growth and cancer progression.

Background: Lactate's perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to a complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial respiration. In addition to its metabolic contributions, lactate has far-reaching repercussions. This review highlights the role of lactate in the course of cancer by highlighting lactylation as a unique epigenetic alteration.

Developing thickened soy protein-based liquid systems: Importance of oil-water interfacial behavior.

Rheological properties are critical in the design of dysphagia foods. Interfacial behavior is a critical factor in determining the rheological properties of emulsions. In this study, dysphagia foods were prepared by thickening soy protein-based liquid systems with xanthan gum, guar gum, and pectin.

Ligusticum cycloprolactam ameliorates hyperuricemic nephropathy through inhibition of TLR4/NF-κB signaling.

Hyperuricemia is a metabolic disease attributed to a sustained dysregulation of purine metabolism, manifesting as consistently elevated blood uric acid levels. Hyperuricemic nephropathy (HN) is a renal complication of hyperuricemia. It is characterized by the deposition of urate crystals, inflammatory cell infiltration and tubulointerstitial injury.

A Study on the Iodine Vapor Adsorption Performance and Desorption Behavior of HKUST-1 with Varying Particle Sizes.

Iodine is one of the key elements that must be removed from the off-gas systems of nuclear fuel reprocessing. This study systematically investigates the iodine vapor adsorption performance of the metal-organic framework (MOF) material HKUST-1(1-(2-methyl-4-(2-oxopyrrolidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one), with particle sizes of 100 nm and 20 μm. HKUST-1 samples with varying particle sizes were synthesized via a hydrothermal method.

Multimodality imaging in cardiac sarcoidosis: A case series of diverse phenotypes.

Cardiac sarcoidosis (CS) represents a rare yet potentially life-threatening condition characterized by non-specific clinical symptoms that maybe easily missed by clinicians. In this case series, the clinical presentations, various imaging modalities' characteristics, and the management of four patients, each with distinct phenotypes of CS confirmed through endomyocardial biopsy, are discussed. Advanced imaging techniques, including positron emission tomography, revealed the focal septal uptake of F fluorodeoxyglucose, which suggests an ongoing inflammation, whereas contrast-enhanced cardiac magnetic resonance demonstrates septal late gadolinium enhancement, which indicates replacement fibrosis.

The role of interleukin-17 in inflammation-related cancers.

Emerging evidence indicates a correlation between inflammation and the development and progression of cancer. Among the various inflammatory signals, interleukin-17 (IL-17) family cytokines serve as a critical link between inflammation and cancer. IL-17 is a highly versatile pro-inflammatory cytokine that plays a pivotal role in host defense, tissue repair, the pathogenesis of inflammatory diseases, and cancer progression.

EBV-miR-BART14-3p Targets LACTB to Enhance Gastric Cancer Cell Proliferation and Migration.

Epstein-Barr virus (EBV), the first human virus identified with oncogenic properties, encodes a class of microRNAs known as miR-BART (BamHI-A rightward transcript microRNAs). This study investigates the pivotal role of EBV-miR-BART14-3p in the progression of gastric cancer, particularly focusing on its effects on epithelial-mesenchymal transition (EMT), cell proliferation, and migration. EBV-associated gastric cancer (EBVaGC) is distinguished by unique genomic and epigenomic characteristics, with EBV miRNAs significantly influencing tumor biology by regulating gene expression.

Visual detection of glyphosate by Al-regulated carbon dots/CdTe quantum dots ratiometric fluorescent sensing platform.

Highly sensitive monitoring of pesticides has garnered attention for food safety. Here, a ratiometric fluorescent probe (AG-CDs-Al/CdTe QDs) was fabricated for specific and sensitive sensing of glyphosate. Surface modifications revealed the chelation-enhanced fluorescence process between the surface -OH of AG-CDs and Al.

Extract Can Be Used as a Raw Material Source for a Sterility Agent for .

Plant sterilants are used to control rodent populations due to their minimal environmental risk and other ethical considerations. However, their practical utilization is unsatisfactory due to high costs and processing difficulties. is a plant material that has shown the potential to inhibit the reproduction of , a species that causes serious damage to crops in the Dongting Lake region in China.

Astragaloside IV inhibits retinal pigment epithelial cell senescence and reduces IL-1β mRNA stability by targeting FTO-mediated mA methylation.

Background: Resistance to senescence in retinal pigment epithelial (RPE) cells can delay the progression of age-related macular degeneration (AMD). However, the mechanisms underlying RPE cell senescence remain inadequately understood, and effective therapeutic strategies are lacking. While astragaloside IV (Ast) has demonstrated anti-aging properties, its specific effects on RPE cell senescence and potential mechanisms are not yet fully clarified.

Estimating the impact of 2D urban landscape patterns on extreme precipitation based on non-stationary models in the Guangdong-Hong Kong-Macao Greater Bay Area, China.

Rapid urbanization has significantly altered surface landscape configurations, leading to complex urban climates. While much attention has been focused on impervious surfaces' impact on extreme precipitation, a critical gap remains in understanding how various 2D urban landscape components influence extreme precipitation across different durations. Through an analysis of the non-stationarity and spatiotemporal variations in extreme precipitation across the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) from 1990 to 2020, we constructed the non-stationary Generalized Additive Models for Location Scale and Shape (GAMLSS) model by introducing six urban landscape structural metrics as explanatory variables for each of the 27 meteorological stations in the GBA.

Empirically validating a computational model of automatic behavior shaping.

Background: Mobile sensing technology allows automated behavior shaping routines to be incorporated into health behavior interventions and other settings. In previous work, a computational model was built to investigate how to best arrange automatic behavior shaping procedures, but the degree to which this model reflects actual human behavior is not known.

Purpose: To translate a previously developed computational model of automatic behavior shaping into an experimental setting.

MicroRNA-204-5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats.

Major depressive disorder (MDD) is usually considered associate with immune inflammation and synaptic injury within specific brain regions. However, the molecular mechanisms underlying the neural deterioration resulting in depression remain unclear. Here, it is found that miR-204-5p is markedly downregulated in the ventromedial prefrontal cortex (vmPFC) in a chronic unpredictable mild stress (CUMS) induce rat model of depression.

EEG-based cross-subject passive music pitch perception using deep learning models.

Pitch plays an essential role in music perception and forms the fundamental component of melodic interpretation. However, objectively detecting and decoding brain responses to musical pitch perception across subjects remains to be explored. In this study, we employed electroencephalography (EEG) as an objective measure to obtain the neural responses of musical pitch perception.

The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.

Metabolic reprogramming fuels cancer cell metastasis and remodels the immunosuppressive tumor microenvironment (TME). We report here that circPETH, a circular RNA (circRNA) transported via extracellular vesicles (EVs) from tumor-associated macrophages (TAMs) to hepatocellular carcinoma (HCC) cells, facilitates glycolysis and metastasis in recipient HCC cells. Mechanistically, circPETH-147aa, encoded by circPETH in an m6A-driven manner, promotes PKM2-catalyzed ALDOA-S36 phosphorylation via the MEG pocket.

A dynamic knee function scoring system for anterior cruciate ligament injuries based on normative six-degree-of-freedom gait pattern.

Background: Traditional examinations of anterior cruciate ligament (ACL) injuries focus primarily on static assessments and lack the ability to evaluate dynamic knee stability. Hence, a dynamic scoring system for knee function is needed in clinical settings. This study aimed to propose a dynamic scoring system based on a large sample of normative six-degree-of-freedom (6-DOF) knee kinematics during gait, and validate its correlation with conventional outcome measurements in assessing ACL-injured knees.

Epicardial adipose tissue: a new link between type 2 diabetes and heart failure-a comprehensive review.

Diabetic cardiomyopathy is a unique cardiomyopathy that is common in diabetic patients, and it is also a diabetic complication for which no effective treatment is currently available. Moreover, relevant studies have revealed that a link exists between type 2 diabetes and heart failure and that abnormal thickening of EAT is inextricably linked to the development of diabetic heart failure. Numerous clinical studies have demonstrated that EAT is implicated in the pathophysiologic process of diabetic myocardial disease.