Effects of levothyroxine therapy on bone and mineral metabolism in hypothyroidism: a systematic review and meta-analysis.

Background: Thyroid hormone plays an important role in accumulating bone development and regulating bone metabolism. It is established that hypothyroidism is linked to increased risk of osteoporosis and fracture. However, the effects of levothyroxine (LT4) treatment on bone for hypothyroid patients remain controversial.

Simultaneous Copper and EDTA Ligands Recovery from Electroless Effluent with Metallic Copper and Formaldehyde.

The traditional treatment of toxic and refractory copper(II)-ethylenediaminetetraacetic acid chelate (Cu(II)-EDTA) in electroless effluents often generates hazardous waste and secondary nitrogen-containing pollutants without maximizing the resource recovery. This study demonstrates a facile strategy to simultaneously recover Cu and EDTA ligands from Cu(II)-EDTA electroless effluent with commercially available metallic Cu and formaldehyde. In this strategy, metallic Cu is used to activate formaldehyde, a prevalent yet often overlooked cocontaminant in Cu(II)-EDTA effluents, to produce highly reductive hydrogen radical (H), which in situ decomplex Cu(II)-EDTA, reduces the central Cu(II) into metallic Cu, and release EDTA ligand.

Gut microbial communities and transcriptional profiles of black soldier fly (Hermitia illucens) larvae fed on fermented sericulture waste.

Sericulture waste poses significant challenges to industrial and environmental safety. Black soldier fly larvae (BSFL) offer a promising solution for organic waste management by converting it into insect protein. This study aimed to develop a microbial fermented method for utilizing sericulture waste to feed BSFL and explore the underlying mechanisms.

Convergent state-control of endogenous opioid analgesia.

Pain is a dynamic and nonlinear experience shaped by injury and contextual factors, including expectations of future pain or relief . While µ opioid receptors are central to the analgesic effects of opioid drugs, the endogenous opioid neurocircuitry underlying pain and placebo analgesia remains poorly understood. The ventrolateral column of the posterior periaqueductal gray is a critical hub for nociception and endogenous analgesia mediated by opioid signaling .

Development and validation of a risk prediction model for multiple organ dysfunction syndrome secondary to severe heat stroke based on immediate assessment indicators on ICU admission.

Introduction: Early prediction of multiple organ dysfunction syndrome (MODS) secondary to severe heat stroke (SHS) is crucial for improving patient outcomes. This study aims to develop and validate a risk prediction model for those patients based on immediate assessment indicators on ICU admission.

Methods: Two hundred eighty-four cases with SHS in our hospital between July 2009 and April 2024 were retrospectively reviewed, and categorized into non-MODS and MODS groups.

Neoadjuvant adebrelimab combined with chemotherapy (cisplatin/carboplatin and etoposide) for limited-stage small-cell lung cancer: a study protocol of phase 2 trial (NIUS).

Introduction: Small-cell lung cancer (SCLC) is a highly malignant neuroendocrine tumour, and concurrent chemoradiotherapy is the current recommended treatment for limited-stage SCLC. However, the overall survival (OS) of patients with SCLC remains poor. Therefore, improving the survival of patients with SCLC and benefitting more patients are urgent clinical requirements.

RBBP6 anchors pre-mRNA 3' end processing to nuclear speckles for efficient gene expression.

Pre-mRNA 3' processing is an integral step in mRNA biogenesis. However, where this process occurs in the nucleus remains unknown. Here, we demonstrate that nuclear speckles (NSs), membraneless organelles enriched with splicing factors, are major sites for pre-mRNA 3' processing in human cells.

Highly selective copper recovery from industrial wastewater via electric field-enhanced ultrafiltration assisted with a picolyl-modified polyelectrolyte.

Copper-containing industrial wastewater, characterized by strong acidity, high ionic strength, and various competing metals, presents significant challenges for Cu(II) recovery. To address these issues, an electric field-enhanced ultrafiltration process was developed, assisted with a functional polyelectrolyte with high selectivity for Cu(II). The polyelectrolyte, termed PPEI, was synthesized by grafting picolyl groups onto polyethyleneimine (PEI), enhancing its affinity for Cu(II).

Resveratrol alleviates blast lung injury by modulating the epithelial sodium channel (ENaC) via the PI3K/AKT pathway.

Blast lung injury (BLI) is a major cause of death in blast injuries, largely due to pulmonary edema. Effective clearance of alveolar fluid is critical for resolving pulmonary edema, with the epithelial sodium channel (ENaC) playing a key role in this process. Resveratrol (RES), a natural compound with known antioxidant and anti-inflammatory properties, has shown promise in treating respiratory diseases.

[Efficacy and learning curve of 69 cases of robot-assisted resection of retroperitoneal benign tumors].

To explore the efficacy of robotic-assisted retroperitoneal benign tumor resection and to analyze its learning curve. This is a retrospective case series study. The data of patients who underwent robotic-assisted retroperitoneal benign tumor resection from August 2015 to February 2023 at the Department of Retroperitoneal Tumor Surgery was analyzed retrospectively.

Single-cell Rapid Capture Hybridization sequencing to reliably detect isoform usage and coding mutations in targeted genes.

Single-cell long-read sequencing has transformed our understanding of isoform usage and the mutation heterogeneity between cells. Despite unbiased in-depth analysis, the low sequencing throughput often results in insufficient read coverage thereby limiting our ability to perform mutation calling for specific genes. Here, we developed a single-cell Rapid Capture Hybridization sequencing (scRaCH-seq) method that demonstrated high specificity and efficiency in capturing targeted transcripts using long-read sequencing, allowing an in-depth analysis of mutation status and transcript usage for genes of interest.

SFAs facilitates ceramide's de novo synthesis via TLR4 and intensifies hepatocyte lipotoxicity.

Background: Non-alcoholic steatohepatitis (NASH), an advanced manifestation of non-alcoholic fatty liver disease (NAFLD), is characterized by hepatocyte injury, inflammation, and fibrosis. Saturated fatty acids (SFAs) have emerged as key contributors to hepatocyte lipotoxicity and disease progression. Toll-like receptor 4 (TLR4) acts as a sentinel for diverse ligands, including lipopolysaccharide (LPS) and endogenous molecules like palmitic acid (PA)-induced ceramide (CER) accumulation, promoting hepatocyte demise.

Assessing genomic diversity and signatures of selection in Qingyuan Wapiti.

Red deer is a species of family Cervidae that is widely distributed in the world and is often raised to provide antlers, as a trophy or traditional medicine materials, and meat. Currently, the whole genomic data for red deer are very limited. Qingyuan Wapiti (QYW), China's first breed of red deer by artificial breeding, is well known for its high yield of antlers and large body size.

Effects of continuous cropping and application of bio-organic fertilizer on photosynthetic performance, dry matter accumulation and distribution of sugar beet.

One of the major problem in the cultivation of sugar beets is continuous cropping obstacle in China. In order to evaluate the effects of continuous cropping year on the photosynthetic performance, dry matter accumulation, and distribution of sugar beet, this study was conducted in the 2020-2021 crop season at the Agriculture and Forestry Sciences of Ulanqab, Inner Mongolia. A split plot system arrangement with three replications was set up to carry out the field testing.

Longitudinal relations among online social activities, peer relationship problems, and well-being in children: The moderating effect of extraversion.

Prior research has predominantly examined the relations between online social activities (OSA) and mental health among adolescents and adults, with comparatively less emphasis placed on children, particularly concerning positive indicators of subjective health, such as well-being. The relations between OSA and well-being are likely intricate and necessitate meticulously designed methodologies to investigate the associations and their underlying mechanisms. This longitudinal study employed the random intercept cross-lagged panel models to explore the dynamic relations between OSA and well-being, considering peer relationship problems as a potential mediator and extraversion as a moderator of the associations, while distinguishing between- and within-person effects.

Comparison of Associations of Food Security Instruments and Mediators With Premature All-Cause and Cardiovascular Disease Death in US Adults.

Background: Food insecurity is associated with high morbidity and mortality and is typically measured with the 10-item US Adult Food Security Survey Module. Shorter instruments may capture similar information, but this has not been validated against mortality in general populations.

Methods: A nationally representative sample of individuals aged 20 to 74 years from the US National Health Interview Survey 2011 to 2018 was included, with deaths linked to the National Death Index through 2019.

Critical Role of Tetrahedral Coordination in Determining the Polysulfide Conversion Efficiency on Spinel Oxides.

Understanding the structure-property relationship and the way in which catalysts facilitate polysulfide conversion is crucial for the rational design of lithium-sulfur (Li-S) battery catalysts. Herein, a series of NiAlO, CoAlO, and CuAlO spinel oxides with varying Ni, Co, or Cu tetrahedral and octahedral site occupancy are studied as Li-S battery catalysts. Combined with experimental and theoretical analysis, the tetrahedral site is identified as the most active site for enhancing polysulfide adsorption and charge transfer.

Preparation, characterization, stability and replenishing calcium ability of Moringa oleifera leaf peptide-calcium chelates.

Calcium deficiency has garnered significant attention as a global public health issue. A new generation of calcium supplements, peptide-calcium chelates, is expected to increase in market value. In this study, we produced MORP (MW < 1 kDa) from Moringa oleifera leaf protein via enzymatic hydrolysis for chelation with Ca to produce MORP-Ca.

HEPATOCYTE GROWTH FACTOR FOR WALKING PERFORMANCE IN PERIPHERAL ARTERY DISEASE.

Introduction: VM202 is a plasmid encoding two isoforms of hepatocyte growth factor (HGF). In preclinical studies, HGF stimulated angiogenesis and muscle regeneration. This preliminary clinical trial tested the hypothesis that VM202 injections in gastrocnemius muscle would improve walking performance in people with mild to moderate and symptomatic lower extremity peripheral artery disease (PAD).

The complete chloroplast genome of Hemsl. 1889 (Ericaceae).

Hemsl. 1889 is an endemic deciduous shrub in China, belonging to the family Ericaceae. In this study, the first complete chloroplast genome of was assembled and annotated.

Post-COVID-19 Vaccination and Long COVID: Insights from Patient-Reported Data.

Introduction: COVID-19 vaccinations reduce the severity and number of symptoms for acute SARS-CoV-2 infections and may reduce the risk of developing Long COVID, also known as post-acute sequelae of SARS-CoV-2 (PASC). Limited and heterogenous data exist on how these vaccinations received after COVID-19 infection might impact the symptoms and trajectory of PASC, once persistent symptoms have developed.

Methods: We investigated the association of post-COVID-19 vaccination with any SARS-CoV-2 vaccine(s) on PASC symptoms in two independent cohorts: a retrospective chart review of self-reported data from patients ( = 128) with PASC seen in the Stanford PASC Clinic between May 2021 and May 2022 and a 2023 multinational survey assessment of individuals with PASC ( = 484).

Electronic Health Literacy and Self-Efficacy Among Primary and Middle School Students in China: A Moderated Mediated Analysis.

Background: The Internet has become a crucial tool for learning, socializing, and entertainment for contemporary minors, and plays an increasingly prominent role in their growth. However, it has been observed that students are often unable to make good judgments about online health information and barely use the Internet to help tackle their health problems. The purpose of this study was to determine the relationship between electronic health literacy (EHL) and general self-efficacy among Chinese primary and middle school students.

Solid-state electrochemiluminescence sensor based on TiO@CdSe and Ru(bpy)@Ag NPs for ultrasensitive detection of malathion.

To sensitively monitor trace-level of malathion (MAT) in vegetable samples, an ultrasensitive solid-state electrochemiluminescence (ECL) sensor was proposed based on TiO@CdSe and Ru(bpy)@Ag NPs. In this system, the introduction of Ag NPs enhanced the initial ECL signal of Ru(bpy)- tripropylamine (TPrA). When TiO@CdSe was introduced into the system, the ECL signal was further enhanced, which may be due to the synergistic effect of the two complexes.

The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer.

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance of the excited states energy dissipations. In this study, a multifunctional iridium(III) complex is exploited by the coordination of an AIE-active N^N ancillary ligand with a trivalent iridium ion. The resultant complex DPTPzIr significantly outperforms its parent ligand in terms of absorption/emission wavelengths, reactive oxygen species (ROS) production, and photothermal conversion, which simultaneously endow DPTPzIr nanoparticles with matched absorption peak to commercial 808 nm laser, the longest NIR-II emission peak (above 1100 nm) among those previously reported AIE iridium(III) complexes, potentiated type-I ROS generation, and as high as 60.

Connexin 43 contributes to perioperative neurocognitive disorder by attenuating perineuronal net of hippocampus in aged mice.

Background: Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms of PND are closely related to perineuronal nets (PNNs). PNNs, which are complexes of extracellular matrix primarily surrounding neurons in the hippocampus, play a critical role in neurocognitive function.