Portable direct spraying porous nanofibrous membranes stent-loaded polymyxin B for treating diabetic wounds with difficult-to-heal gram-negative bacterial infections.

Gram-negative bacteria infections in diabetic wounds are complicated to control, leading to amputation and even death in severe cases. There is an urgent need to develop effective therapeutic strategies. In recent years, electrospinning has attracted much attention due to its resemblance to extracellular matrix (ECM), which can regulate local cellular proliferation, migration, differentiation, etc.

FNDC5/Irisin mitigates high glucose-induced neurotoxicity in HT22 cell via ferroptosis.

Diabetes-induced neuropathy represents a major etiology of dementia, highlighting an urgent need for the development of effective therapeutic interventions. In this study, we explored the role of fibronectin type III domain containing 5 (FNDC5)/Irisin in mitigating hyperglycemia-induced neurotoxicity in HT22 cells and investigated the underlying mechanisms. Our findings reveal that high glucose conditions are neurotoxic, leading to reduced viability of HT22 cells and increased apoptosis.

Bidirectional transitions of sarcopenia states in older adults: The longitudinal evidence from CHARLS.

Background: Sarcopenia, the age-related loss of muscle mass and function, brings multiple adverse outcomes including disability and death. Several sarcopenia consensuses have newly introduced the premorbid concept of possible sarcopenia and recommended early lifestyle interventions. Bidirectional transitions of premorbid states have been revealed in several chronic diseases yet not clarified in sarcopenia.

Traceability Research on Geographic Based on High-Resolution Mass Spectrometry and Chemometric Analysis.

A method was developed to identify and trace the geographic sources of using high-resolution mass spectrometry and chemometrics. The representative samples were collected from the geographic area of Honghe Dengzhanhua and other areas in Yunnan province and Guizhou province. The data points could be determined well using the PCA and PLS-DA diagram.

Factors associated with SARS-CoV-2 vaccine hesitancy after stroke: a cross-sectional study.

Background: The vaccination status of post-stroke patients, who are at high risk of severe outcomes from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a significant concern, yet it remains unclear. We aimed to explore the vaccination status, factors associated with vaccine hesitancy, and adverse effects after vaccination among post-stroke patients.

Methods: This multi-center observational study enrolled hospitalized post-stroke patients from six Chinese hospitals (Oct 1, 2020 - Mar 31, 2021), examining vaccine uptake and self-reported reasons for vaccine hesitancy, utilizing logistic regression to investigate risk factors for vaccine hesitancy, and recording any adverse reactions post-vaccination.

Functional hemostatic hydrogels: design based on procoagulant principles.

Uncontrolled hemorrhage results in various complications and is currently the leading cause of death in the general population. Traditional hemostatic methods have drawbacks that may lead to ineffective hemostasis and even the risk of secondary injury. Therefore, there is an urgent need for more effective hemostatic techniques.

Circulating antibodies to Helicobacter pylori are associated with biomarkers of neurodegeneration in cognitively intact adults.

Helicobacter pylori (H. pylori) infection confers risk for Alzheimer's Disease (AD), with the mechanisms unknown. Infections are linked to the etiology of AD partly through modulating the humoral immunity post-infection.

Investigation of Novel Thermosetting Copolymer-Based Monomethylolurea-Glyoxal for Wood Manufacturing.

The purpose of this investigation was to design novel alternating copolymers (monomethylolurea-glyoxal, MMU-G) as adhesives for wood manufacturing. MMU-G were synthesized under acid (pH = 5) conditions. After the 120-day storage period, the MMU-G resins were used for plywood production, which exhibited a wet shear strength of about 2.

Curative efficacy of surgical procedures for older patients with femoral neck fracture: a network meta-analysis and systematic review.

Background: Femoral neck fractures have a higher incidence in older people with poor prognosis, inducing serious social problems. Common treatment methods include total hip arthroplasty, bipolar hemiarthroplasty, double-screw fixation, multiple-screw fixation, and dynamic hip system.

Methods: We searched through four electronic databases, including PubMed, Web of Science, Cochrane Library, and Embase databases, for articles regarding femoral neck fractures, bone screw, and hip prosthesis published up to February 11, 2020.

Trigger finger at the wrist caused by an intramuscular lipoma within the carpal tunnel: A case report.

Background: Trigger finger at the wrist, which occurs with finger movement, is an uncommon presentation. Few reports describing cases of trigger finger at the wrist have been published. Thus, we present a case of an intramuscular lipoma arising from an anomalous flexor digitorum muscle belly in a 48-year-old female patient causing painful finger triggering at the wrist and carpal tunnel syndrome (CTS).

A Modelling Study on PM-Related Health Impacts from Climate Change and Air Pollution Emission Control - China, 2010s and 2040s.

Climate change and air pollution are two important environmental issues in China. It is important to investigate particulate matter with aerodynamic diameter less than 2.5 μm (PM)-related health impacts from climate change and air pollution emission control.

Morphology genetic 3D hierarchical SnOmicrostructures constructed by Sub 5 nm nanocrystals for highly sensitive ethanol-sensor.

SnOis widely used for ethanol-sensing applications due to its excellent physicochemical properties, low toxicity and high sensitivity. However it is a challenge to construct 3D-hierarchical structures with sub 5 nm primary grain particle, which is the optimized size for ethanol sensor. Herein, genetic tri-level hierarchical SnOmicrostructures are synthesised by the genetic conversion of 3D hierarchical SnSflowers assembled by ultrathin nanosheets.

Extensile lateral versus sinus tarsi approach for calcaneal fractures: A meta-analysis.

Background: Calcaneal fractures are the most common tarsal bone fracture, and are often accompanied by heel pain, local swelling, tenderness, and inability to walk or stand. Surgical intervention results in better reconstruction of the calcaneal anatomy and reduces future complications; however, the optimal incision approach is still controversial. The incision is exposed better with extensile lateral approach (ELA), while the sinus tarsi approach (STA) causes fewer complications.

Treatment of volar defects of the finger using dorsal digital-metacarpal flap versus free medial plantar artery flap: a comparative study.

Background: The treatment of defects on the volar surface of the finger has been scarcely reported, and its utility for digital resurfacing remains unclear. This study compared the outcomes of free medial plantar artery flap (MPAF) and dorsal digital-metacarpal flap (DDMF) in finger reconstruction.

Methods: This retrospective cohort study included 24 patients with soft-tissue defects on the volar surface of the finger from March 2014 to March 2017.

Bone graft versus non-bone graft for treatment of calcaneal fractures: A protocol for meta-analysis.

Background: Calcaneal fractures are a prevalent form of injury caused by high-energy trauma. This study aimed at investigating whether bone graft and non-bone graft are essential for the internal fixation of calcaneal fractures. A meta-analysis of relevant clinical studies evaluated radiographic parameters, functional outcomes, and complications that offer practical recommendations on the suitability of bone grafts for the management of Calcaneal fractures.

CPEB3 regulates neuron-specific alternative splicing and involves neurogenesis gene expression.

In the mammalian brain, alternative pre-mRNA splicing is a fundamental mechanism that modifies neuronal function dynamically where secretion of different splice variants regulates neurogenesis, development, pathfinding, maintenance, migration, and synaptogenesis. Sequence-specific RNA-Binding Protein CPEB3 has distinctive isoform-distinct biochemical interactions and neuronal development assembly roles. Nonetheless, the mechanisms moderating splice isoform options remain unclear.

Polymer-Based Scaffold Strategies for Spinal Cord Repair and Regeneration.

The injury to the spinal cord is among the most complex fields of medical development. Spinal cord injury (SCI) leads to acute loss of motor and sensory function beneath the injury level and is linked to a dismal prognosis. Currently, while a strategy that could heal the injured spinal cord remains unforeseen, the latest advancements in polymer-mediated approaches demonstrate promising treatment forms to remyelinate or regenerate the axons and to integrate new neural cells in the SCI.

Self-Supported NaTi(PO) Nanorod Arrays: Balancing Na and Electron Kinetics via Optimized Carbon Coating for High-Power Sodium-Ion Capacitor.

The NaTi(PO) (NTP) anode materials exhibit high Na diffusion dynamics; carbon-based materials can effectively improve its limited electronic conductivity. However, the low Na diffusion of NTP/C composite materials from inhomogeneous carbon mixing or uncontrollable carbon coating cannot keep up with fast electron transfer, leading to undesirable electrochemical performances. Herein, a uniform and controllable carbon layer is designed on the self-supported-coated NTP nanorod arrays with binder-free (NTP@C NR) to improve Na and electron kinetics simultaneously.

Improvement of the fast simulation of gamma-gamma density well logging measurement.

The fast modeling of gamma-gamma density well logging is essential for the inversion techniques of formation properties, which is usually carried out jointly with other logging measurements such as electrical logging. It also can help to adjust the initial geological model in real time during geosteering. The Monte Carlo method is the foremost numerical technique to simulate gamma-gamma density logging measurement.

Interaction between Schwann cells and other cells during repair of peripheral nerve injury.

Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system injured nerves can effectively regenerate depending on the location and severity of injury. Peripheral myelinating glia, Schwann cells (SCs), interact with various cells in and around the injury site and are important for debris elimination, repair, and nerve regeneration. Following PNI, Wallerian degeneration of the distal stump is rapidly initiated by degeneration of damaged axons followed by morphologic changes in SCs and the recruitment of circulating macrophages.

Acute compartment syndrome secondary to anterolateral thigh flap harvesting in a pediatric patient: A case report.

Introduction: The anterolateral thigh (ALT) flap is the most popularly used flap for major soft tissue reconstruction. Although it is widely used, acute compartment syndrome (ACS) in pediatric patients has rarely been reported in the literature. We herein reported a case of ACS in a 6-year-old girl after ALT flap harvest with direct closure of the donor site.

Lipoma in the pronator quadratus: A case report.

Rationale: Lipomas are common benign tumors, constituting 16% of soft tissue mesenchymal tumors. They usually occur under the skin or in the large muscles of the thigh, shoulder, or upper arm. There are few reported cases of lipomas located in the forearm and hand muscles, accounting for less than 1% of all lipomas.

The ability of oriental magpies () to solve baited multiple-string problems.

Background: Baited multiple-string problems are commonly used in avian laboratory studies to evaluate complex cognition. Several bird species possess the ability to use a string pull for obtaining food.

Methods: We initially tested and trained 11 magpies to determine whether the oriental magpie () possesses the ability to solve baited multiple-string problems.

Spatiotemporal and probability variations of surface PM over China between 2013 and 2019 and the associated changes in health risks: An integrative observation and model analysis.

We used statistical methods and the GEOS-Chem model to interpret the observed spatiotemporal and probability variations of surface PM concentrations in China from December 2013 to November 2019, as well as to assess the drivers for the variations and the implications for health risks associated with long-term and short-term exposure to PM. Annual and seasonal PM concentrations have decreased over most areas in China during the 6-year period. We decomposed the observed day-to-day variation of PM concentrations in eastern Chinese cities and found that it showed two distinct major spatial modes, which fluctuated in strength seasonally.