Poly(lactide)/poly(butylene adipate-co-terephthalate)/carbon nanotubes composites with robust mechanical properties, fatigue-resistance and dielectric properties.

A styrene-glycidylmethacrylate-1-allyl-3-vinylimidazole epoxy functionalized ionomer (EFI) was synthesized, and the EFI and carbon nanotubes (CNTs) were co-introduced into poly(lactide)/poly(butylene-adipate-co-terephtalate) (PLA/PBAT) blends to fabricate high performance composites with excellent mechanical properties, fatigue-resistance and dielectric properties. It is revealed that EFI can improve the interaction force between PLA and PBAT by inducing the interfacial crosslink reaction, thereby improving the melt strength of the samples. EFI can also refine the dispersion of CNT in the composites owing to the non-covalent force between EFI and CNT, promote the formation of filler network inside composites, which is demonstrated by DMA and rheological test results.

Enhancing the Pseudocapacitive Energy Storage of Coordination Polymers by Artificially Constructed Defective Sites Anchoring Redox-Active Species.

Coordination polymers (CPs) have emerged as potential energy storage materials for supercapacitors due to their tunable chemical composition, structural diversity, and multielectron redox-active sites. However, besides poor cycling stability, the practical application of dense CPs in supercapacitors is generally limited by low specific capacitance and high resistance, which are caused by their low specific surface area and dense frameworks, resulting in insufficient redox reactions of metal sites and poor ion diffusion, respectively. Here, we synthesize a new dense CP {CP-1: [Ce(obb)(HCOO)]} via self-assembly of the Ce cation and 4,4'-oxidibenzoate (obb).

Copper-Catalyzed Asymmetric Nucleophilic Substitutions of TsSCF: Synthesis of Chiral SCF-Containing Compounds.

By employing electrophilic TsSCF as an efficient SCF source, we reported Cu/ (chiral sulfoxide-phosphine ligand)-catalyzed enantioselective nucleophilic substitutions. Under this protocol, α-pyridyl-α-fluoro esters as latent carbon nucleophiles, compounds containing a C-SCF stereocenter along with azacycles and fluorine atoms, were obtained in good yields and enantioselectivities under mild conditions (up to 68% yield, 92% ee).

Laser-induced graphene/gold nanoparticle hybrid sensor for enhanced electrochemical detection of paracetamol.

This research presents a highly sensitive and selective electrochemical sensor for detecting paracetamol. The sensor is created using laser direct-writing on a flexible PI substrate to form LIG electrodes. Gold nanoparticles (AuNPs) are then synthesized on the working electrode through secondary laser reduction, resulting in an AuNPs/LIG composite.

Discovery of Imidazo[1,2-]pyrazine Derivatives as Potent ENPP1 Inhibitors.

ENPP1 acts as a negative regulator of the cGAS-STING pathway through the hydrolysis of 2'3'-cGAMP. Inhibitors of ENPP1 are regarded as promising agents for stimulating the immune response in cancer immunotherapy. This study describes the identification and optimization of imidazo[1,2-]pyrazine derivative as a highly potent and selective ENPP1 inhibitor.

Pharmacological mechanisms of Taohe Chengqi decoction in diabetic cardiovascular complications: A systematic review, network pharmacology and molecular docking.

Background: Diabetic cardiovascular complications are the leading cause of diabetes-related deaths. These complications place an enormous and growing burden on global health systems and economies. The objective of this study was to conduct a systematic review on the therapeutic mechanisms of Taohe Chengqi Decoction (THCQD) in the treatment of diabetic cardiovascular complications.

Theoretical and experimental studies on channel impulse response of short-range non-line-of-sight ultraviolet communications.

A theoretical channel impulse response (CIR) model of short-range non-line-of-sight (NLOS) ultraviolet communications (UVC) in noncoplanar geometry under the single-scatter condition is proposed. Simulation results obtained from the widely accepted Monte-Carlo (MC)-based channel model of NLOS UVC are provided to verify corresponding theoretical results obtained from the proposed theoretical single-scatter CIR model. Additionally, an outdoor experiment with a light-emitting diode (LED) as the light source is first designed to measure the channel step response of NLOS UVC and to further validate the proposed theoretical single-scatter CIR model.

Rectosigmoid intussusception due to large submucosal lipoma mimicking rectal prolapse.

Rectosigmoid intussusception is a rare cause of bowel obstruction, accounting for only approximately 1%-2% of all bowel obstruction cases. While intussusception in adults typically occurs intra-abdominally and presents with signs and symptoms of intestinal obstruction, in rare cases, it can mimic a rectal prolapse if the intussusceptum protrudes through the anal canal. We herein report a case where an octogenarian woman presented with rectosigmoid intussusception through the anal canal, due to a sigmoid colon submucosal lipoma, who eventually required an open Hartmann's procedure.

Identifying Diagnostic and Prognostic Differentially Expressed Genes of Gastric Cancer Based on Bioinformatics Analyses of RNA-seq Data.

The abnormal expression of genes in serum may be associated with early diagnosis of patients with malignant tumors. This study was designed to screen for significantly differentially expressed genes (DEGs) that may be associated with gastric cancer using bioinformatic methods. RNA-seq data from gastric cancers were downloaded from the TCGA and GEO databases, and 1903 secretory genes were downloaded from the HPA database.

Modular Assembly of MXene Frameworks for Noninvasive Disease Diagnosis via Urinary Volatiles.

Volatile organic compounds (VOCs) in urine are valuable biomarkers for noninvasive disease diagnosis. Herein, a facile coordination-driven modular assembly strategy is used for developing a library of gas-sensing materials based on porous MXene frameworks (MFs). Taking advantage of modules with diverse composition and tunable structure, our MFs-based library can provide more choices to satisfy gas-sensing demands.

Single-collision-induced path loss model of reflection-assisted non-line-of-sight ultraviolet communications.

By considering both scattering and reflection events as collision-induced events (CIEs), an analytical path loss model of reflection-assisted non-line-of-sight (NLOS) ultraviolet communications (UVC) is proposed with single CIE incorporated, which refers to the single-collision-induced (SCI) path loss model. More specifically, the analytical expressions of the received optical energy resulting from single-scatter and single-reflection events in reflection-assisted NLOS UVC are respectively derived. Then, in terms of those two expressions, the expression of the proposed SCI path loss model is obtained.

Modeling of ultraviolet propagation from air to human epidermis with wavelength range of 200-300 nm.

Ultraviolet (UV) technology plays an important role in the fields of sterilization, disinfection, and short-range wireless optical communications. In this Letter, a theoretical model to determine the UV radiation intensity (UVRI) on human skin is put forward based on the Monte Carlo method, where the UV wavelength ranges from 200 to 300 nm. Meanwhile, the UVRI evaluation algorithm is provided to reproduce the simulation results.

Repetitive Mild Closed Head Injury in Adolescent Mice Is Associated with Impaired Proteostasis, Neuroinflammation, and Tauopathy.

Repetitive mild traumatic brain injury (mTBI) in children and adolescents leads to acute and chronic neurologic sequelae and is linked to later life neurodegenerative disease. However, the biological mechanisms connecting early life mTBI to neurodegeneration remain unknown. Using an adolescent mouse repetitive closed head injury model that induces progressive cognitive impairment in males and anxiety in females in the absence of overt histopathology, we examined transcriptional and translational changes in neurons isolated from sham and injured brain in the chronic phase after injury.

Application of Electrocardiogram Localization during Peripherally Inserted Central Catheter Line Insertion into the Persistent Left Superior Vena Cava of Neonates.

Background: Most neonates with persistent left superior vena cava (PLSVC) have no clinical symptoms or hemodynamic changes, and this anomaly is only found during cardiac catheterization, pacemaker implantation, or central venous catheterization. Electrocardiogram (ECG) localization is helpful for the application of the peripherally inserted central catheter (PICC) technique in neonates with PLSVC.

Objective: To explore the characteristic waveforms of the P wave when a PICC under ECG localization is applied in neonates with PLSVC.

Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis.

Traumatic brain injury (TBI) is a leading cause of death and disability with no specific effective therapy, in part because disease driving mechanisms remain to be elucidated. Receptor interacting protein kinases (RIPKs) are serine/threonine kinases that assemble multi-molecular complexes that induce apoptosis, necroptosis, inflammasome and nuclear factor kappa B activation. Prior studies using pharmacological inhibitors implicated necroptosis in the pathogenesis of TBI and stroke, but these studies cannot be used to conclusively demonstrate a role for necroptosis because of the possibility of off target effects.

The efficacy and safety of Xuesaitong injection combined with western medicines in the treatment of ischemic stroke: an updated systematic review and meta-analysis.

Background: Due to constantly emerging new studies on Xuesaitong injection (XST) agent, it is necessary to summarize and analyze the latest published clinical research data to re-evaluate the clinical efficacy and safety of XST. This study mainly aimed to evaluate the clinical efficacy and safety of XST combined with western medicines (WM) for ischemic stroke treatment.

Methods: The related databases were searched to collect all randomized controlled trials (RCTs) comparing the combination of XST and WM with WM alone for the treatment of patients with ischemic stroke.

Single-scatter path loss model of LED-based non-line-of-sight ultraviolet communications: publisher's note.

This publisher's note contains corrections to Opt. Lett.46, 4013 (2021)OPLEDP0146-959210.

Single-scatter path loss model of LED-based non-line-of-sight ultraviolet communications.

Light-emitting diodes (LEDs) are popularly used as light sources in non-line-of-sight (NLOS) ultraviolet communications (UVC). However, currently reported single-scatter path loss (PL) models of NLOS UVC links assume that the radiant intensity of the light source is uniformly distributed within the beam divergence angle, which cannot well characterize the light emission pattern of LEDs. In this Letter, we propose a single-scatter PL model for LED-based NLOS UVC systems, and the corresponding analytical expression is derived by modeling the LED emission pattern as a Lambertian distribution.

Lenticulostriate artery combined with neuroimaging markers of cerebral small vessel disease differentiate the pathogenesis of recent subcortical infarction.

Recent subcortical infarction (RSI) in the lenticulostriate artery (LSA) territory with a non-stenotic middle cerebral artery is a heterogeneous entity. We aimed to investigate the role of LSA combined with neuroimaging markers of cerebral small vessel disease (CSVD) in differentiating the pathogenic subtypes of RSI by whole-brain vessel-wall magnetic resonance imaging (WB-VWI). Fifty-two RSI patients without relevant middle cerebral artery (MCA) stenosis on magnetic resonance angiography were prospectively enrolled.

Redescriptions of two parasitoids, Yang (Hymenoptera, Eupelmidae) and Nixon (Hymenoptera, Braconidae), parasitizing Descarpentries & Villiers (Coleoptera, Buprestidae) in China with keys to genera or species groups.

Two parasitoids, Yang (Hymenoptera, Eupelmidae) and Nixon (Hymenoptera, Braconidae) are redescribed and illustrated. Both were reared from Descarpentries & Villiers (Coleoptera, Buprestidae) boring in Brand (Symplocaceae). is a solitary parasitoid with a parasitism rate of about 13.

Mirror movements induced by hemiballism due to putamen infarction: a case report and literature review.

Mirror movements (MMs), which are involuntary movements of one limb that synchronously mirror voluntary movements of the contralateral limb, are a relatively uncommon complication of strokes. Here we report what appears to be the first case of putamen infarction manifesting as MMs in one side of the body induced by contralateral hemiballism. MMs and hemiballism were nearly entirely eliminated after one week of clonazepam and haloperidol therapy.

Application of a modified electrocardiogram-guided technique for umbilical venous catheterisation in neonates: A retrospective trial.

Aim: To investigate the effectiveness and safety of modified electrocardiogram (ECG)-guided technique in umbilical venous catheterisation in neonates.

Methods: Sixty-six critically ill neonates underwent umbilical venous catheterisation with (ECG group) or without (control group) ECG guidance from January 2017 to March 2019. We retrospectively analysed and compared the rate of correct tip placement on first try, unplanned extubation rate and incidence of catheter-related complications between the two groups.

Pentacoordinated Al -Stabilized Active Pd Structures on Al O -Coated Palladium Catalysts for Methane Combustion.

Supported Pd catalysts are active in catalyzing the highly exothermic methane combustion reaction but tend to be deactivated owing to local hyperthermal environments. Herein we report an effective approach to stabilize Pd/SiO catalysts with porous Al O overlayers coated by atomic layer deposition (ALD). Al magic angle spinning NMR analysis showed that Al O overlayers on Pd particles coated by the ALD method are rich in pentacoordinated Al sites capable of strongly interacting with adjacent surface PdO phases on supported Pd particles.

Design of self-assembly dipeptide hydrogels and machine learning via their chemical features.

Hydrogels that are self-assembled by peptides have attracted great interest for biomedical applications. However, the link between chemical structures of peptides and their corresponding hydrogel properties is still unclear. Here, we showed a combinational approach to generate a structurally diverse hydrogel library with more than 2,000 peptides and evaluated their corresponding properties.