Publications by authors named "Tiah C L Oates"
Article Synopsis
- After a tissue injury, inflammatory cells immediately respond to clear debris and manage other cells for repair, but their role can be both beneficial and detrimental.
- This study examines the use of protocells loaded with R848 to reprogram innate immune cells in zebrafish, observing significant changes in inflammatory responses during skin and skeletal repair.
- The research shows that R848-reprogrammed macrophages enhance healing outcomes by improving bactericidal activities and positively influencing processes vital for recovery, with findings also applicable to human macrophages.
Several immune cell-expressed miRNAs (miRs) are associated with altered prognostic outcome in cancer patients, suggesting that they may be potential targets for development of cancer therapies. Here, translucent zebrafish (Danio rerio) is utilized to demonstrate that genetic knockout or knockdown of one such miR, microRNA-223 (miR223), globally or specifically in leukocytes, does indeed lead to reduced cancer progression. As a first step toward potential translation to a clinical therapy, a novel strategy is described for reprogramming neutrophils and macrophages utilizing miniature artificial protocells (PCs) to deliver anti-miRs against the anti-inflammatory miR223.
View Article and Find Full Text PDF