Unravelling the structure of CO in silica adsorbents: an NMR and computational perspective.

This comprehensive review describes recent advancements in the use of solid-state NMR-assisted methods and computational modeling strategies to unravel gas adsorption mechanisms and CO speciation in porous CO-adsorbent silica materials at the atomic scale. This work provides new perspectives for the innovative modifications of these materials rendering them more amenable to the use of advanced NMR methods.

Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.

Mutations in the gene, which encodes the polycystin-2 (PC2, also called TRPP2) protein, lead to autosomal dominant polycystic kidney disease (ADPKD). As a member of the transient receptor potential (TRP) channel superfamily, PC2 functions as a non-selective cation channel. The activation and regulation of the PC2 channel are largely unknown, and direct binding of small-molecule ligands to this channel has not been reported.

Rural communities experience higher radon exposure versus urban areas, potentially due to drilled groundwater well annuli acting as unintended radon gas migration conduits.

Repetitive, long-term inhalation of radioactive radon gas is one of the leading causes of lung cancer, with exposure differences being a function of geographic location, built environment, personal demographics, activity patterns, and decision-making. Here, we examine radon exposure disparities across the urban-to-rural landscape, based on 42,051 Canadian residential properties in 2034 distinct communities. People living in rural, lower population density communities experience as much as 31.

Field investigation of the transport and attenuation of fugitive methane in shallow groundwater around an oil and gas well with gas migration.

'Fugitive' or 'stray' gas migration from deeper formations due to well bore integrity failure has prompted concern regarding environmental impacts. Unintended methane (CH) migration can increase greenhouse gas emissions and affect groundwater quality in the critical zone. Although the CH transport in shallow aquifers has been investigated at experimental injection sites, no intensive groundwater studies have been published around an oil and gas well that has been leaking for a significant period of time.

Dysglycemia Shapes Visceral Adipose Tissue's Response to GIP, GLP-1 and Glucagon in Individuals with Obesity.

Visceral adipose tissue (VAT) metabolic fingerprints differ according to body mass index (BMI) and glycemic status. Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon are gut-associated hormones that play an important role in regulating energy and glucose homeostasis, although their metabolic actions in VAT are still poorly characterized. Our aim was to assess whether GLP-1, GIP and glucagon influence the VAT metabolite profile.

The diverse effects of pathogenic point mutations on ion channel activity of a gain-of-function polycystin-2.

Autosomal dominant polycystic kidney disease is caused by mutations in PKD1 or PKD2 genes. The latter encodes polycystin-2 (PC2, also known as TRPP2), a member of the transient receptor potential ion channel family. Despite most pathogenic mutations in PKD2 being truncation variants, there are also many point mutations, which cause small changes in protein sequences but dramatic changes in the in vivo function of PC2.

Regular Voluntary Running is Associated with Increased Tumor Vascularization and Immune Cell Infiltration and Decreased Tumor Growth in Mice.

Tumors present dysfunctional vasculature that limits blood perfusion and hinders immune cells delivery. We aimed to investigate if regular voluntary running promotes tumor vascular remodelling, improves intratumoral immune cells infiltration and inhibits tumor growth. Tumors were induced in C57BL/6 male mice (n=28) by subcutaneous inoculation in the dorsal region with a suspension of RM1 cells (1.

Obesity-Related Genes Expression in Testes and Sperm Parameters Respond to GLP-1 and Caloric Restriction.

: Calorie restriction (CR) diets and glucagon-Like Peptide-1 (GLP-1) analogs are known to alter energy homeostasis with the potential to affect the expression of obesity-related genes (ORGs). We hypothesized that CR and GLP-1 administration can alter ORGs expression in spermatozoa and testes, as well as the sperm parameters implicated in male fertility. Six-week-old adult male Wistar rats (n = 16) were divided into three groups, submitted either to CR (n = 6, fed with 30% less chow diet than the control rats), GLP-1 administration (n = 5, 3.

In-Well Degassing of Monitoring Wells Completed in Gas-Charged Aquifers.

Total dissolved gas pressure (P ) measurements are useful to measure accurate in situ dissolved gas concentrations in groundwater, but challenged by in-well degassing. Although in-well degassing has been widely observed, its cause(s) are not clear. We investigated the mechanism(s) by which gas-charged groundwater in a recently pumped well becomes degassed.

The effect of ocean warming on accumulation and cellular responsiveness to cobalt in Mytilus galloprovincialis.

Cobalt (Co) is among the hazardous substances identified in aquatic environments. Industrialization and population growth have also contributed to climate change, namely in what concerns ocean temperature rise. The aim of the present study was to evaluate the influence of temperature rise on the impacts caused by Co on Mytilus galloprovincialis.

Applying the Human Appropriation of Net Primary Production framework to map provisioning ecosystem services and their relation to ecosystem functioning across the European Union.

Human intervention on land enhances the supply of provisioning ecosystem services, but also exerts pressures on ecosystem functioning. We utilize the Human Appropriation of Net Primary Production (HANPP) framework to assess these relations in European agriculture, for 220 NUTS2 regions. We put a particular focus on individual land system components, i.

Free-Phase Gas Detection in Groundwater Wells via Water Pressure and Continuous Field Parameters.

Detection of free-phase gas (FPG) in groundwater wells is critical for accurate assessment of dissolved gas concentrations and the occurrence of FPG in the subsurface, with consequent implications for understanding groundwater contamination and greenhouse gas emissions. However, identifying FPG is challenging during routine groundwater monitoring and there is poor agreement on the best approach to detect the occurrence of FPG in groundwater. In this study, laboratory experiments in a water column were designed to mimic nonflowing and flowing conditions in a groundwater well to evaluate how the presence of FPG affects water pressure and commonly used continuous field parameters.

Global process-based characterization factors of soil carbon depletion for life cycle impact assessment.

Regionalization of land use (LU) impact in life cycle assessment (LCA) has gained relevance in recent years. Most regionalized models are statistical, using highly aggregated spatial units and LU classes (e.g.

Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.

Background: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be partially accountable for the observed phenotypic variability.

Visceral Adipose Tissue Displays Unique Metabolomic Fingerprints in Obesity, Pre-Diabetes and Type 2 Diabetes.

Visceral adipose tissue (VAT) metabolic profiling harbors the potential to disentangle molecular changes underlying obesity-related dysglycemia. In this study, the VAT exometabolome of subjects with obesity and different glycemic statuses are analyzed. The subjects ( = 19) are divided into groups according to body mass index and glycemic status: subjects with obesity and euglycemia (Ob+NGT, = 5), subjects with obesity and pre-diabetes (Ob+Pre-T2D, = 5), subjects with obesity and type 2 diabetes under metformin treatment (Ob+T2D, = 5) and subjects without obesity and with euglycemia (Non-Ob, = 4), used as controls.

Can the recycling of europium from contaminated waters be achieved through living macroalgae? Study on accumulation and toxicological impacts under realistic concentrations.

Europium (Eu) strategic importance for the manufacturing industry, high economic value and high supply risk, categorizes it as critical raw material. Due to anthropogenic contamination, Eu levels in ecosystems have been growing, which opens opportunities for innovation: its recovery and recycling from contaminated water as element source - circular economy. In this pioneering study, six widely available living marine macroalgae (Ulva intestinalis, Ulva lactuca, Gracilaria sp.

Regular Voluntary Running Inhibits Androgen-Independent Prostate Cancer Growth in Mice.

Introduction: Benefits of regular physical exercise were demonstrated as preventive and coadjuvant nonpharmacological anticancer therapy. However, the role of exercise in modulating prostate cancer behavior has yet to be established.

Methods: Prostate tumors were induced in C57BL/6 male mice (n = 28) by subcutaneous inoculation of a suspension of murine androgen-independent RM1 cells (1.

Use of flash glucose monitoring for post-bariatric hypoglycaemia diagnosis and management.

Our aim was to assess the potential of flash glucose monitoring (FGM) for diagnostic workup of suspected post-bariatric hypoglycaemia (PBH). Patients (N = 13) with suspected PBH underwent a food and symptoms diary (FSD) record along with FGM over 14 days. Targeted data analysis confirmed the occurrence of low glucose events in parallel to meal-triggered symptoms.

Food systems in a zero-deforestation world: Dietary change is more important than intensification for climate targets in 2050.

Global food systems contribute to climate change, the transgression of planetary boundaries and deforestation. An improved understanding of the environmental impacts of different food system futures is crucial for forging strategies to sustainably nourish a growing world population. We here quantify the greenhouse gas (GHG) emissions of global food system scenarios within a biophysically feasible "option space" in 2050 comprising all scenarios in which biomass supply - calculated as function of agricultural area and yields - is sufficient to cover biomass demand - derived from human diets and the feed demand of livestock.

Toxicological effects of the rare earth element neodymium in Mytilus galloprovincialis.

The wide range of applications of rare earth elements (REE) is leading to their occurrence in worldwide aquatic environments. Among the most popular REE is Neodymium (Nd), being widely used in permanent magnets, lasers, and glass additives. Neodymium-iron-boron (NdFeB) magnets is the main application of Nd since they are used in electric motors, hard disk drives, speakers and generators for wind turbines.

New insights on the impacts of e-waste towards marine bivalves: The case of the rare earth element Dysprosium.

With the technological advances and economic development, the multiplicity and wide variety of applications of electrical and electronic equipment have increased, as well as the amount of end-of-life products (waste of electrical and electronic equipment, WEEE). Accompanying their increasing application, there is an increasing risk to aquatic ecosystems and inhabiting organisms. Among the most common elements present in WEEE are rare earth elements (REE) such as Dysprosium (Dy).

Caloric restriction alters the hormonal profile and testicular metabolome, resulting in alterations of sperm head morphology.

Energy homeostasis is crucial for all physiological processes. Thus, when there is low energy intake, negative health effects may arise, including in reproductive function. We propose to study whether caloric restriction (CR) changes testicular metabolic profile and ultimately sperm quality.

Detailed global modelling of soil organic carbon in cropland, grassland and forest soils.

Assessments of the global carbon (C) cycle typically rely on simplified models which consider large areas as homogeneous in terms of the response of soils to land use or consider very broad land classes. For example, "cropland" is typically modelled as an aggregation of distinct practices and individual crops over large regions. Here, we use the process-based Rothamsted soil Carbon Model (RothC model), which has a history of being successfully applied at a global scale, to calculate attainable SOC stocks and C mineralization rates for each of c.