Benchmarking commercially available value-added fractions with potential for production via microalgae-based biorefineries: is it worth it?

The urgent need to mitigate climate change requires finding sustainable and efficient alternatives to fossil fuel-based materials. Biosequestration by microalgae has been suggested as a potential method for climate change mitigation due to its environmentally friendly nature and ability to produce high-value compounds. However, the large-scale application of microalgal biorefineries faces significant challenges, particularly in the harvest and processing stages, which are often costly and energy-intensive.

Biodegradable Microplastics from Agricultural Mulch Films: Implications for Plant Growth-Promoting Bacteria and Plant's Oxidative Stress.

This study explores the interactions between biodegradable (BIO) microplastics and plant growth-promoting bacteria (PGPB), assessing their effects on soil health and crop productivity. Five bacterial strains, , , , , and , were exposed to BIO microplastics to examine strain-specific responses. This study revealed that while most bacteria experienced growth inhibition, sp.

Iron biomarkers predict peripheral artery disease in females.

Background And Aim: Iron overload has been proposed as a risk factor for atherosclerosis, but the available data are controversial. Here, we investigated whether iron status shows sex-specific associations with peripheral arterial disease (PAD).

Methods: Using two different analytical approaches (machine-learning and logistic regression), we studied the association between blood iron biomarkers and PAD in 368 individuals from the Heidelberg Study on Diabetes and Complications (HEIST-DiC) and in 5101 individuals from the National Health and Nutrition Examination Survey (NHANES 1999-2004).

Evidence-Based Umbrella Review of Non-Invasive Neuromodulation in Chronic Neuropathic Pain.

Background And Objective: Non-invasive neuromodulation techniques (NIN), such as transcranial Direct Current Stimulation (tDCS) and repetitive Transcranial Magnetic Stimulation (rTMS), have been extensively researched for their potential to alleviate pain by reversing neuroplastic changes associated with neuropathic pain (NP), a prevalent and complex condition. However, treating NP remains challenging due to the numerous variables involved, such as different techniques, dosages and aetiologies. It is necessary to provide insights for clinicians and public healthcare managers to support clinical decision-making.

Bacterial Volatile Organic Compounds as a Strategy to Increase Drought Tolerance in Maize ( L.): Influence on Plant Biochemistry.

Maize is highly susceptible to drought, which affects growth and yield. This study investigated how bacterial volatile organic compounds (BVOCs) affect maize drought tolerance. Drought reduced shoot size but increased root length, an adaptation for accessing deeper soil moisture.

TSG-6 Is Involved in Fibrous Structural Remodeling after the Injection of Adipose-derived Stem Cells.

Background: Although aesthetic treatments can rejuvenate the skin, they often cause specific forms of tissue damage. Unlike wounding, which typically results in fibrotic scar tissue, damage from aesthetic treatments induces a distinct histological rejuvenation. The mechanisms that drive this rejuvenation are not yet fully understood.

How Bacteria Cope with Oxidative Stress Induced by Cadmium: Volatile Communication Is Differentially Perceived among Strains.

Soil is an environment with numerous niches, where bacteria are exposed to diverse conditions. Some bacteria are exposed earlier than others to pressure, and the emission of signals that other bacteria can receive and perceive may allow a better response to an eminent stimulus. To shed light on how bacteria trigger their response and adapt to changes in the environment, the intra- and interspecific influences of volatiles on bacterial strains growing under non-stressed and cadmium-stressed conditions were assessed.

Enhancing diagnostic accuracy of multiple myeloma through ML-driven analysis of hematological slides: new dataset and identification model to support hematologists.

Multiple Myeloma (MM) is a hematological malignancy characterized by the clonal proliferation of plasma cells within the bone marrow. Diagnosing MM presents considerable challenges, involving the identification of plasma cells in cytology examinations on hematological slides. At present, this is still a time-consuming manual task and has high labor costs.

Novel Twenty20 batting simulations: a strategy for research and improved practice.

Twenty20 cricket and batting in particular have remained vastly understudied to date. To elucidate the effects of batting on the batter, tools which replicate match play in controlled environments are essential. This study describes the development of two Twenty20 batting simulations, for a high and low strike rate innings, generated from retrospective analysis of international and domestic competition.

Ultrasound-Guided Radiofrequency Ablation for Chronic Hip Pain Due to Osteoarthritis.

Background And Aims: Hip osteoarthritis (OA) has a prevalence of 2.9% in Portugal and is a related cause of pain and disability. A sufficient number of patients report these symptoms even after total hip arthroplasty (THA), while others are contraindicated to such surgery and suffer from uncontrolled pain.

Increased Delta and Theta Power Density in Sickle Cell Disease Individuals with Chronic Pain Secondary to Hip Osteonecrosis: A Resting-State Eeg Study.

Purpose: Identify the presence of a dysfunctional electroencephalographic (EEG) pattern in individuals with sickle cell disease (SCD) and hip osteonecrosis, and assess its potential associations with depression, anxiety, pain severity, and serum levels of brain-derived neurotrophic factor (BDNF).

Methods: In this cross-sectional investigation, 24 SCD patients with hip osteonecrosis and chronic pain were matched by age and sex with 19 healthy controls. Resting-state EEG data were recorded using 32 electrodes for both groups.

Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges.

Lung cancer is a highly aggressive neoplasm and, despite the development of recent therapies, tumor progression and recurrence following the initial response remains unsolved. Several questions remain unanswered about non-small cell lung cancer (NSCLC): (1) Which patients will actually benefit from therapy? (2) What are the predictive factors of response to MAbs and TKIs? (3) What are the best combination strategies with conventional treatments or new antineoplastic drugs? To answer these questions, an integrative literature review was carried out, searching articles in PUBMED, NCBI-PMC, Google Academic, and others. Here, we will examine the molecular genetics of lung cancer, emphasizing NSCLC, and delineate the primary categories of inhibitors based on their molecular targets, alongside the main treatment alternatives depending on the type of acquired resistance.

An Unlikely Cause of Groin Pain: Obturator Externus Tear in a Professional Soccer Player.

Groin pain is a common and complex problem in athletes, especially soccer players, associated with a wide variety of possible injuries in numerous anatomical structures. One of the causes of groin pain is damage to the deep muscles of the hip region, with isolated traumatic injury of the obturator externus muscle rarely described and probably underdiagnosed. This report describes a clinical case of a soccer player who presented with acute hip pain and buttock pain resulting from a rapid change of position in load, associated with pain with active hip external rotation and passive internal rotation.

The Role of Extracorporeal Shock Wave Therapy in the Treatment of Muscle Injuries: A Systematic Review.

Muscle injuries commonly occur in sports and can be classified as indirect and direct, according to the 2013 Munich Consensus Statement (MCS). Since recent evidence suggests that extracorporeal shock wave therapy (ESWT) improves muscular microcirculation and may increase regeneration after acute muscle injury, we performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines to access the efficacy and safety of ESWT in the treatment of patients with muscle injuries. PubMed and Cochrane were searched to screen for potentially relevant articles and the literature search was last updated in June 2023.

Analysis of upper limb propulsion in young swimmers in front-crawl through Statistical Parametric Mapping.

This study aimed to: (i) verify the within-subject effect of the dominant and non-dominant upper limb propulsion during consecutive arm-pulls through discrete (average) and continuous analysis (SPM), and; (ii) compare young swimmers' propulsion between both upper limbs through discrete (average) and continuous analysis (Statistical Parametric Mapping - SPM). The sample consisted of 17 young male swimmers (age = 16.02 ± 0.

Development of an Enhanced High-Yield Influenza Vaccine Backbone in Embryonated Chicken Eggs.

Vaccination is an efficient approach to preventing influenza virus infections. Recently, we developed influenza A and B virus vaccine backbones that increased the yield of several vaccine viruses in Madin-Darby canine kidney (MDCK) and African green monkey kidney (Vero) cells. These vaccine backbones also increased viral replication in embryonated chicken eggs, which are the most frequently used platform for influenza vaccine manufacturing.

Comparison of swimming velocity between age-group swimmers through discrete variables and continuous variables by Statistical Parametric Mapping.

The aim of this study was to compare the swimming velocity in front-crawl between age-group swimmers using discrete variables against Statistical Parametric Mapping (SPM). The sample consisted of 30 young male swimmers divided into three groups (each with 10 swimmers) based on their age (group #1: 13.60 ± 0.

Full-scale network analysis reveals properties of the FV protein structure organization.

Blood coagulation is a vital process for humans and other species. Following an injury to a blood vessel, a cascade of molecular signals is transmitted, inhibiting and activating more than a dozen coagulation factors and resulting in the formation of a fibrin clot that ceases the bleeding. In this process, the Coagulation factor V (FV) is a master regulator, coordinating critical steps of this process.

A graph-based machine learning framework identifies critical properties of FVIII that lead to hemophilia A.

Blood coagulation is an essential process to cease bleeding in humans and other species. This mechanism is characterized by a molecular cascade of more than a dozen components activated after an injury to a blood vessel. In this process, the coagulation factor VIII (FVIII) is a master regulator, enhancing the activity of other components by thousands of times.

Computational analyses reveal fundamental properties of the AT structure related to thrombosis.

Summary: Blood coagulation is a vital process for humans and other species. Following an injury to a blood vessel, a cascade of molecular signals is transmitted, inhibiting and activating more than a dozen coagulation factors and resulting in the formation of a fibrin clot that ceases the bleeding. In this process, antithrombin (AT), encoded by the SERPINC1 gene is a key player regulating the clotting activity and ensuring that it stops at the right time.

Bacteria Associated with the Roots of Common Bean ( L.) at Different Development Stages: Diversity and Plant Growth Promotion.

Current agricultural methodologies are vulnerable to erratic climate and are dependent on cost-intensive fertilization to ensure high yields. Sustainable practices should be pursued to ensure food security. L.

Using Statistical Parametric Mapping to Compare the Propulsion of Age-Group Swimmers in Front Crawl Acquired with the Aquanex System.

Understanding the difference in each upper limb between age groups can provide deeper insights into swimmers’ propulsion. This study aimed to: (1) compare swimming velocity and a set of kinematical variables between junior and juvenile swimmers and (2) compare the propulsion outputs through discrete and continuous analyses (Statistical Parametric Mapping—SPM) between junior and juvenile swimmers for each upper limb (i.e.

Numerical and experimental methods used to evaluate active drag in swimming: A systematic narrative review.

In swimming, it is necessary to understand and identify the main factors that are important to reduce active drag and, consequently, improve the performance of swimmers. However, there is no up-to-date review in the literature clarifying this topic. Thus, a systematic narrative review was performed to update the body of knowledge on active drag in swimming through numerical and experimental methods.

A Machine Learning Framework Predicts the Clinical Severity of Hemophilia B Caused by Point-Mutations.

Blood coagulation is a vital physiological mechanism to stop blood loss following an injury to a blood vessel. This process starts immediately upon damage to the endothelium lining a blood vessel, and results in the formation of a platelet plug that closes the site of injury. In this repair operation, an essential component is the coagulation factor IX (FIX), a serine protease encoded by the F9 gene and whose deficiency causes hemophilia B.

Sickle cell disease chronic joint pain: Clinical assessment based on maladaptive central nervous system plasticity.

Chronic joint pain (CJP) is among the significant musculoskeletal comorbidities in sickle cell disease (SCD) individuals. However, many healthcare professionals have difficulties in understanding and evaluating it. In addition, most musculoskeletal evaluation procedures do not consider central nervous system (CNS) plasticity associated with CJP, which is frequently maladaptive.