Publications by authors named "Tiago Barcelos Valiatti"

Article Synopsis
  • * This study focuses on three multidrug-resistant (MDR) bacterial isolates found in the stool samples of swine and bovine in Brazil, all belonging to the same clone and carrying various antimicrobial resistance genes (ARGs).
  • * Whole genome sequencing of one isolate revealed resistance to several types of antibiotics and highlighted genetic similarities with bacteria found in animals and humans in the USA and Malaysia, indicating a concerning spread of antibiotic-resistant pathogens in the food supply.
View Article and Find Full Text PDF

The aim of this study was to compare the in vitro activity of delafloxacin with other fluoroquinolones against bacterial pathogens recovered from inpatients with osteomyelitis, Acute Bacterial Skin and Skin-Structure Infections (ABSSSI). In total, 100 bacterial isolates (58 % Gram-negative and 42 % Gram-positive) recovered from inpatients between January and April 2021, were reidentified at species level by MALDI-TOF MS. Antimicrobial susceptibility testing was conducted using the broth microdilution method and the detection of biofilm formation was assessed through the microtiter plate assay.

View Article and Find Full Text PDF

Klebsiella pneumoniae is an important pathogen that causes several human infections, which is currently among the main bacterial species of clinical importance. Given the importance of understanding the characteristics of this pathogen and its evolutionary aspects, in this study, we sought to characterize strains of K. pneumoniae recovered in the 1980s and 1990s in São Paulo, Brazil.

View Article and Find Full Text PDF

Brazil is recognized for its biodiversity and the genetic variability of its organisms. This genetic variability becomes even more valuable when it is properly documented and accessible. Understanding bacterial diversity through molecular characterization is necessary as it can improve patient treatment, reduce the length of hospital stays and the selection of resistant bacteria, and generate data for health and epidemiological surveillance.

View Article and Find Full Text PDF

Aeromonas spp. are frequently encountered in aquatic environments, with Aeromonas veronii emerging as an opportunistic pathogen causing a range of diseases in both humans and animals. Recent reports have raised public health concerns due to the emergence of multidrug-resistant Aeromonas spp.

View Article and Find Full Text PDF

is a Gram-negative bacterium presenting intrinsic resistance to polymyxins that has emerged as an important human pathogen. Although previous studies reported the occurrence of multidrug-resistance (MDR) isolates in the nosocomial settings, herein, we described isolates of this extensively drug-resistant (XDR) species recovered from stool samples of food-producing animals in the Brazilian Amazon region. Three carbapenem-resistant strains were recovered from stool samples of poultry and cattle.

View Article and Find Full Text PDF

Fosfomycin disodium is a potential therapeutic option to manage difficult-to-treat infections, especially when combined with other antimicrobials. In this study, we evaluated the activity of fosfomycin in combination with meropenem or polymyxin B against contemporaneous KPC-2-producing clinical isolates (KPC-KPN). Synergistic activity was assessed by checkerboard (CKA) and time-kill (TKA) assays.

View Article and Find Full Text PDF
Article Synopsis
  • * Whole-genome sequencing of KP411 uncovered various resistance genes against multiple antibiotic classes, including β-lactams and aminoglycosides.
  • * The strain is linked to the ST258 clonal lineage, known for spreading KPC-2, indicating that food-producing animals could be key reservoirs for multidrug-resistant bacteria affecting humans and the environment.
View Article and Find Full Text PDF

Objective: Herein, this study aimed to perform the genomic characterization of a bla positive Klebsiella pneumoniae (KP1.1JP) strain isolated from the surface water of river located the Brazilian Amazon region.

Methods: Antimicrobial susceptibility testing was performed following BrCAST/EUCAST recommendations.

View Article and Find Full Text PDF
Article Synopsis
  • The report highlights a multicentric study conducted in Brazil to assess bacterial communities and antimicrobial resistance genes (ARGs) in food-producing animals and healthy humans, using rectal swabs from various regions.
  • The findings revealed a high level of microbial diversity with over 21,000 unique species identified, alongside 405 ARGs linked to multiple antibiotic classes, including previously unreported carbapenemase-encoding genes.
  • The study emphasizes the interconnectedness of humans and animals in the spread of antimicrobial resistance, particularly in low- and middle-income countries, and advocates for enhanced surveillance through One Health approaches.
View Article and Find Full Text PDF
Article Synopsis
  • - The One Health concept explores the links between human and animal health, focusing on how various microorganisms transfer between humans and animals, but lacks publicly available genomic data.
  • - This study collects a dataset of 2,915 metagenome-assembled genomes (MAGs) from 107 samples, including human and livestock gut microbiomes from various regions in Brazil, with a breakdown of high and medium-quality drafts.
  • - The findings provide insights into the diversity of gut microbiomes, indicating potential pathogens and new species, and offer a chance to improve our understanding of microbial ecology and discover beneficial biotechnological applications.
View Article and Find Full Text PDF

spp. remain the leading biofilm-forming agents causing orthopedic implant-associated infections (OIAI). This is a descriptive study of phenotypic and genomic features identified in clinical isolates of and coagulase-negative (CoNS) recovered from OIAIs patients that progressed to treatment failure.

View Article and Find Full Text PDF

While primarily Gram-positive bacteria cause bacterial eye infections, several Gram-negative species also pose eye health risks. Currently, few studies have tried to understand the pathogenic mechanisms involved in eye infections. Therefore, this study aimed to establish the pathogenic potential of strains isolated from eye infections.

View Article and Find Full Text PDF

In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A.

View Article and Find Full Text PDF

Extraintestinal pathogenic Escherichia coli (ExPEC) is a leading cause of human and animal infections worldwide. The utilization of selective and differential media to facilitate the isolation and identification of E. coli from complex samples, such as water, food, sediment, and gut tissue, is common in epidemiological studies.

View Article and Find Full Text PDF

Uropathogenic (UPEC) strains are responsible for most cases of urinary tract infections worldwide. We present the draft whole-genome sequence of the UPEC 252 strain, which carries the gene that encodes the intimin adhesin. Intimin promotes intimate adherence of enteropathogenic and enterohemorrhagic to intestinal cells.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session0llbg1l6t3il48uqiau1kiejjhjjscqr): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once