Immunogenicity and safety of seasonal influenza vaccines in children under 3 years of age.

Introduction: Despite children aged 6-35 months developing more severe influenza infections, not all countries include influenza vaccines in their national immunization programs.

Areas Covered: This literature review examines the efficacy, immunogenicity, and safety of seasonal trivalent influenza vaccines (TIVs) and quadrivalent influenzae vaccines (QIVs) in children 6-35 months old to determine if greater valency promotes greater protection while maintaining a similar safety profile.

Expert Opinion: TIVs and QIVs are safe for children under 3 years old.