Long-term outcomes of stage IIB-IV melanoma patients: nationwide data from Norway.

This study was performed to investigate the characteristics and overall survival (OS) of patients with completely resected stage IIB-IV cutaneous melanoma identified in the Cancer Registry of Norway. A retrospective cohort study of all adult patients with stage ≥IIB cutaneous melanoma was performed in Norway (January 2008 to December 2018), excluding patients with stage IV melanoma without evidence of surgery. 5-year OS varied by stage (IIB 65%, IIC 38%, IIIA 79%, IIIB 66%, IIIC 52%, IIID 37% and IV 39%).

A Systematic, Unbiased Mapping of CD8 and CD4 T Cell Epitopes in Yellow Fever Vaccinees.

Examining CD8 and CD4 T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8 and 50 CD4 T cell epitopes, many inducing strong and prevalent (i.e., immunodominant) T cell responses.

Adventure tourism and schistosomiasis: serology and clinical findings in a group of Danish students after white-water rafting in Uganda.

Introduction: Diagnosis of schistosomiasis in travellers is a clinical challenge, since cases may present with no symptoms or a few non-specific symptoms. Here, we report on the laboratory and clinical findings in Danish travellers exposed to -infested water during white-water rafting on the Ugandan part of the upper Nile River in July 2009.

Case Presentation: Forty travellers were offered screening for -specific antibodies.

Infection Mimicking Progression of Scleroderma.

This case report describes a patient with scleroderma who developed infection, which for more than a year mimicked worsening of her connective tissue disorder. The patient was diagnosed with scleroderma based on puffy fingers that developed into sclerodactyly, abnormal nail fold capillaries, interstitial lung disease, Raynaud's phenomenon, esophageal dysmotility, and positivity for rheumatoid factor and anti-SSA antibodies. She developed massive inflammatory changes of the cutis, the subcutis, and the muscle fasciae of the right leg, that after several failed attempts of immunosuppressive treatments were found to be caused by .

Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination.

Outbreaks of Yellow Fever occur regularly in endemic areas of Africa and South America frequently leading to mass vaccination campaigns straining the availability of the attenuated Yellow Fever vaccine, YF-17D. The WHO has recently decided to discontinue regular booster-vaccinations since a single vaccination is deemed to confer life-long immune protection. Here, we have examined humoral (neutralizing antibody) and cellular (CD8 and CD4 T cell) immune responses in primary and booster vaccinees (the latter spanning 8 to 36 years after primary vaccination).

A cost-utility analysis of ingenol mebutate gel for the treatment of actinic keratosis: a Scottish perspective.

Background: Actinic keratosis (AK) is a UV-induced, pre-malignant skin condition that is common in adults over 60 years of age with fair skin in Scotland. The most commonly prescribed first-line treatment for AK in Scotland is currently diclofenac gel (3 %). Ingenol mebutate gel is a recently developed topical therapy available in two strengths for the treatment of AK lesions on the face and scalp (150 mcg/g once daily for 3 consecutive days) or trunk and extremities (500 mcg/g once daily for 2 consecutive days).

Immune response after one or two doses of pandemic influenza A (H1N1) monovalent, AS03-adjuvanted vaccine in HIV infected adults.

Introduction: Continued research is needed to evaluate and improve the immunogenicity of influenza vaccines in HIV infected patients. We aimed to determine the antibody responses after one or two doses of the AS03-adjuvanted pandemic influenza A (H1N1) vaccine in HIV infected patients.

Method: Following the influenza season 2009/2010, 219 HIV infected patients were included and divided into three groups depending on whether they received none (n=60), one (n=31) or two (n=128) doses of pandemic influenza A (H1N1) vaccine.

Cystic echinococcosis of the liver: experience from a Danish tertiary reference center (2002-2010).

Background: Cystic echinococcosis (CE) of the liver can be treated with ultrasound-guided puncture, aspiration, injection, and re-aspiration (PAIR), with surgery and with benzimidazole derivatives. The aim of this study was to review available data concerning treatment modality and outcome for patients treated for CE of the liver in a Danish tertiary reference center.

Methods: A search was made for patients treated for CE infection between January 1, 2002 and January 1, 2010.

[African Tick Bite Fever upon game hunting in South Africa].

The incident of spotted fever imported to Denmark is unknown. We present a classic case of African Tick Bite Fever (ATBF) to highlight a disease, which frequently infects wildlife enthusiasts and hunters on vacation in South Africa. ATBF has a good prognosis and is easily treated with doxycycline.

High rate of failure in treatment of imported schistosomiasis.

Background: There is an increasing number of imported cases of schistosomiasis in Europe, but there are only few studies on the efficacy of praziquantel for the treatment of schistosomiasis in non-endemic settings.

Methods: Patients treated for schistosomiasis in 2003 to 2008 were offered reexamination with serology, eosinophil count, IgE, microscopy of 24 h urine samples and/or rectal biopsies >3 months after treatment. All patients had been treated with at least one dose of praziquantel 40 to 60 mg/kg >12 weeks after exposure and had not been reexposed to schistosomiasis after treatment.

[Schistosomiasis in Danish travellers and immigrants].

Introduction: The purpose of the study was to describe symptoms and diagnosis of schistosomiasis in travellers and immigrants based on patients diagnosed and treated at the State University Hospital in Copenhagen in 2003-2008.

Material And Methods: Retrospective review of patient records.

Results: A total of 49 patients (39 travellers and ten immigrants) were diagnosed with schistosomiasis.

Strongyloidiasis--the most neglected of the neglected tropical diseases?

Soil-transmitted helminths of the genus Strongyloides (S. fuelleborni and the more prevalent S. stercoralis) are currently believed to infect an estimated 30-100 million people worldwide.

[Ebola--haemorrhagic fever].

This review presents the latest findings on ebola. Ebola presents one of the highest case-fatality rates of all infectious diseases, and in 2007 outbreaks were observed first in the Democratic Republic of Congo and later in Uganda with a new subtype. Accumulating evidence suggests that fruit bats are a likely reservoir for the ebola virus.

[Hemorrhagic Rift Valley fever].

A case of fatal hemorrhagic Rift Valley fever during an epidemic in Kenya's North Eastern Province in January 2007 is described.

[Ocular complications of dengue fever].

We report a case of a 32-year-old Danish woman with ocular complications of (IgM-verified) dengue fever. After having returned from a trip to Thailand, she became ill with fever and symptoms suggestive of dengue. On the tenth day, when the fever had subsided, she suddenly experienced visual disturbances and was admitted to hospital.

[Screening of people with fever returning to Denmark from "the tropics"].

A number of febrile diseases imported from the tropics, above all malaria, may, if left untreated, endanger the life of the patient. Microscopy of malaria slides without delay is by far the most important diagnostic tool in all patients who may have been exposed to infection. An accurate, detailed travel history, a knowledge of infections prevalent in areas where the patient has been and a thorough physical examination are essential.

[Screening of apparently healthy people returning from "the tropics"].

Screening for imported parasites and infections in apparently healthy travellers and immigrants from the tropics is made more difficult by the lack of specificity and sensitivity of the standard investigations of blood and stools. Investigations must focus on parasites and infections prevalent in the area where the person has been. In the majority of people returned from the tropics, no infections or parasites are detected.

Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark.

Background: Previous experience with unacceptable adverse effects with mefloquine as treatment for uncomplicated Plasmodium falciparum malaria prompted an evaluation of the effectiveness and side effects of atovaquone-proguanil (Malarone) in a hospital setting.

Methods: Atovaquone-proguanil was given as standard treatment (1,000/400 mgq.d.