Publications by authors named "Thuy-Dung Nguyen"
Objective: Major depressive disorder (MDD) is highly heterogeneous. Standard typology partly captures the disorder's symptomatic heterogeneity, although whether it adequately captures etiological heterogeneity remains elusive. The aim of this study was to investigate the genetic characterization of MDD heterogeneity.
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- Major depressive disorder (MDD) is a highly prevalent psychiatric condition in Scandinavian countries, with the study analyzing data from nearly 273,000 cases over a span of several decades to assess its prevalence, treatment, and genetic factors.
- Many MDD cases exhibit severe trajectories, including high rates of recurrence, comorbid disorders, and a significant number requiring inpatient care or facing suicide.
- Although MDD statistics were consistent across Norway, Denmark, and Sweden, differences in healthcare organization highlight the importance of considering these factors when making cross-country comparisons; the findings aim to inform better prevention and intervention strategies for policy makers.
Despite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been associated with lower RA risk. We aimed to explore the repurposing potential of antidiabetic drugs in RA prevention by assessing associations between genetic variation in antidiabetic drug target genes and RA using Mendelian randomization (MR).
View Article and Find Full Text PDFMembers of the DJ-1 protein family are multifunctional enzymes whose loss increases the susceptibility of the cell to oxidative stress. However, little is known about the function of the plant DJ-1 homologs. Therefore, we analyzed the effect of oxidation on the structure and function of chloroplastic AtDJ-1B and studied the phenotype of T-DNA lines lacking the protein.
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