Design and assessment of an energy self-supply process producing tetraethyl orthosilicate using rice husk.

Combusting rice husk (RH) generates energy and rice husk ash (RHA) containing high amount of silica. Recent studies showed RHA can directly react with ethanol for producing tetraethyl orthosilicate (TEOS), an important substance for different industries. Nevertheless, this process requires an intensive energy supply.

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, a constitutively active tyrosine kinase fusion gene responsible for an abnormal proliferation of leukemic stem cells (LSCs). Inhibition of BCR-ABL1 kinase activity offers long-term relief to CML patients. However, for a proportion of them, BCR-ABL1 inhibition will become ineffective at treating the disease, and CML will progress to blast crisis (BC) CML with poor prognosis.