Synthesis and crystal structure of peptide dimethyl biphenyl hybrid CHNO·0.25HO.

The synthesis and crystal structure of peptide 6,6'-dimethyl biphenyl hybrid are described. The title compound was synthesized by reaction between 6,6'-dimethyl-[1,1'-biphen-yl]-2,2'-dicarbonyl dichloride in CHCl, amine HN-proline-phenyl-alanine-alanine-COOMe and EtN at 273 K under N atmosphere and characterized by single-crystal X-ray diffraction. The asymmetric unit contains one peptide mol-ecule and a quarter of a water mol-ecule.

Crystal structure of a tripeptide biphenyl hybrid CHNO·0.5HO.

A peptide biphenyl hybrid compound {systematic name: dimethyl 2,2'-[((2,2')-2,2'-{[(2,2')-1,1'-([1,1'-biphen-yl]-2,2'-dicarbon-yl)bis-(pyrrolidine-1,2-diyl-2-carbon-yl)]bis-(aza-nedi-yl)}bis-(3-phenyl-propano-yl))bis-(aza-nedi-yl)](2,2')-dipropionate hemihydrate}, CHNO·0.5HO, was prepared by coupling of [1,1'-biphen-yl]-2,2'-dicarbonyl dichloride, tri-ethyl-amine and the tripeptide Pro-Phe-Ala in CHCl at 273 K under an N atmosphere. In the crystal, the asymmetric unit contains the peptide biphenyl hybrid accompanied by one-half of a water mol-ecule.