Prunes May Blunt Adverse Effects of Oral Contraceptives on Bone Health in Young Adult Women: A Randomized Clinical Trial.

Background: Oral contraceptives (OCs) may promote bone loss, thereby leading to suboptimal bone health later in life. Research is needed to determine whether dietary interventions can blunt OC-related bone loss; prune consumption, shown to be effective in improving bone density in previous studies, could provide a safe and inexpensive solution.

Objectives: The purpose of this study was to determine whether 12 mo of consuming 50 g of prunes daily would prevent bone loss or increase bone accrual in young (18-25 y) OC users.

The genetic landscape of a metabolic interaction.

While much prior work has explored the constraints on protein sequence and evolution induced by physical protein-protein interactions, the sequence-level constraints emerging from non-binding functional interactions in metabolism remain unclear. To quantify how variation in the activity of one enzyme constrains the biochemical parameters and sequence of another, we focus on dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), a pair of enzymes catalyzing consecutive reactions in folate metabolism. We use deep mutational scanning to quantify the growth rate effect of 2696 DHFR single mutations in 3 TYMS backgrounds under conditions selected to emphasize biochemical epistasis.

Removal of perfluoroalkyl acids (PFAAs) from aqueous solution by water hyacinth (Eichhornia crassipes): Uptake, accumulation, and translocation.

Although Eichhornia crassipes, commonly known as water hyacinth, has been widely used in wastewater treatment, further investigations are still needed to explore the removal efficiency of perfluoroalkyl acids (PFAAs) from the aqueous environment using this floating aquatic plant. In this study, a hydroponic experiment was conducted to assess accumulation, bioconcentration factors (BCFs), translocation factors (TFs), and removal rates of eight PFAAs by water hyacinth. The obtained results indicated that all PFAAs, including five perfluoroalkyl carboxylic acids (PFCAs) with chain lengths C4-C8 and three perfluoroalkyl sulfonic acids (PFSAs) with C4, C6, and C8, were readily accumulated in water hyacinth.

The Genetic Landscape of a Metabolic Interaction.

Enzyme abundance, catalytic activity, and ultimately sequence are all shaped by the need of growing cells to maintain metabolic flux while minimizing accumulation of deleterious intermediates. While much prior work has explored the constraints on protein sequence and evolution induced by physical protein-protein interactions, the sequence-level constraints emerging from non-binding functional interactions in metabolism remain unclear. To quantify how variation in the activity of one enzyme constrains the biochemical parameters and sequence of another, we focused on dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), a pair of enzymes catalyzing consecutive reactions in folate metabolism.

Minimap: An interactive dynamic decision making game for search and rescue missions.

Many aspects of humans' dynamic decision-making (DDM) behaviors have been studied with computer-simulated games called microworlds. However, most microworlds only emphasize specific elements of DDM and are inflexible in generating a variety of environments and experimental designs. Moreover, despite the ubiquity of gridworld games for Artificial Intelligence (AI) research, only some tools exist to aid in the development of browser-based gridworld environments for studying the dynamics of human decision-making behavior.

Fostering Collective Intelligence in Human-AI Collaboration: Laying the Groundwork for COHUMAIN.

Artificial Intelligence (AI) powered machines are increasingly mediating our work and many of our managerial, economic, and cultural interactions. While technology enhances individual capability in many ways, how do we know that the sociotechnical system as a whole, consisting of a complex web of hundreds of human-machine interactions, is exhibiting collective intelligence? Research on human-machine interactions has been conducted within different disciplinary silos, resulting in social science models that underestimate technology and vice versa. Bringing together these different perspectives and methods at this juncture is critical.

Postural sway is not affected by estrogen fluctuations during the menstrual cycle.

When people stand still, they exhibit a phenomenon called postural sway, or spontaneous movement of the body's center of pressure, which is related to balance control. In general females show less sway than males, but this difference only begins to appear around puberty, pointing to different levels of sex hormones as one potential mechanism for sway sex differences. In this study, we followed cohorts of young females using oral contraceptives (n = 32) and not using oral contraceptives (n = 19), to investigate associations between estrogen availability and postural sway.

Spontaneous pulmonary herniation in COVID-19.

Spontaneous pulmonary hernia (SPH) is a rare condition. We report a case secondary to extreme coughing and COVID-19 infection. The patient displayed several clinical features typical of this diagnosis; difficult to manage pain on coughing, flank haematoma and bulging of the chest wall on coughing.

SpeedyIBL: A comprehensive, precise, and fast implementation of instance-based learning theory.

Instance-based learning theory (IBLT) is a comprehensive account of how humans make decisions from experience during dynamic tasks. Since it was first proposed almost two decades ago, multiple computational models have been constructed based on IBLT (i.e.

SHOX2 methylation in Vietnamese patients with lung cancer.

Background: DNA methylation on cytosine in the CpG dinucleotides is one of the most common epigenetic perturbations taking place during cancer initiation, progression, occurrence and resistance therapy. DNA methylation seems to be sufficiently stable epigenetic modification to be utilized as a cancer biomarker in in vitro diagnostic (IVD) settings. Nowadays, the SHOX2 methylation (mSHOX2) is one of the most valuable DNA methylation biomarkers of lung cancer that is the leading cause of cancer death.

Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria.

Background: In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed target doses of 0.25 or 0.

Theory of Mind From Observation in Cognitive Models and Humans.

A major challenge for research in artificial intelligence is to develop systems that can infer the goals, beliefs, and intentions of others (i.e., systems that have theory of mind, ToM).

Determination of Per- and Polyfluoroalkyl Substances in Craft Villages and Industrial Environments of Vietnam.

Per- and polyfluoroalkyl substances (PFASs) have attracted great concern because of their great recalcitrant nature and harmful environmental health effects. Eight PFASs in wastewater from craft villages and industrial environments of Vietnam were analyzed using liquid chromatography triple quadrupole mass spectrometry (LC-MS/MS) with negative electrospray ionization interface. For analysis of PFASs, percent recoveries ranged from 87 to 112, and MQL varied from 0.

Occurrence, Distribution, and Ecological Risk Assessment of Antibiotics in Selected Urban Lakes of Hanoi, Vietnam.

Residue concentrations of fifteen antibiotics including sulfonamides, quinolones, macrolides, -lactams, and trimethoprim in lakes from Hanoi metropolitan area, Vietnam, were analyzed using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC/MS-MS) to elucidate their occurrence and behavior in urban environment. For surface water, the average concentrations of five antibiotic classes decreased in the order: sulfonamides (117.9 ng/L) > -lactams (31.

Gene expression profiling in allopurinol-induced severe cutaneous adverse reactions in Vietnamese.

To examine gene expression in different clinical phenotypes of allopurinol-induced severe cutaneous adverse reactions (SCARs). Gene expression profiling was performed using microarray on 11 RNA samples (four controls, three hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms, four Stevens-Johnson syndrome/toxic epidermal necrolysis) followed by quantitative real-time PCR in a total of 11 SCARs patients and 11 controls. The biological pathways which were significantly enriched in differentially expressed genes in Stevens-Johnson syndrome/toxic epidermal necrolysis compared with hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms patients included; cell surface interactions at the vascular wall, immunoregulatory interactions at the immunological synapse and MyD88 signaling pathways.

Functional Nanostructured Oligochitosan⁻Silica/ Carboxymethyl Cellulose Hybrid Materials: Synthesis and Investigation of Their Antifungal Abilities.

Functional hybrid materials were successfully synthesized from low-cost waste products, such as oligochitosan (OCS) obtained from chitosan (one of the main components in crab shells) and nanosilica (nSiO₂) obtained from rice husk, in a 1:1 ratio (/), and their dispersion in the presence of carboxymethyl cellulose at pH 7 was stable for over one month without aggregation. The molecular weights, chemical structures, morphologies, and crystallinities of the obtained materials were characterized by GPC, FTIR, TEM, and XRD, respectively. The antifungal effects of OCS, nSiO₂, and the OCS/nSiO hybrid materials were investigated via a disk-diffusion method.

Mouse fat storage-inducing transmembrane protein 2 (FIT2) promotes lipid droplet accumulation in plants.

Fat storage-inducing transmembrane protein 2 (FIT2) is an endoplasmic reticulum (ER)-localized protein that plays an important role in lipid droplet (LD) formation in animal cells. However, no obvious homologue of FIT2 is found in plants. Here, we tested the function of FIT2 in plant cells by ectopically expressing mouse (Mus musculus) FIT2 in Nicotiana tabacum suspension-cultured cells, Nicotiana benthamiana leaves and Arabidopsis thaliana plants.

Arabidopsis TH2 Encodes the Orphan Enzyme Thiamin Monophosphate Phosphatase.

To synthesize the cofactor thiamin diphosphate (ThDP), plants must first hydrolyze thiamin monophosphate (ThMP) to thiamin, but dedicated enzymes for this hydrolysis step were unknown and widely doubted to exist. The classical thiamin-requiring th2-1 mutation in Arabidopsis thaliana was shown to reduce ThDP levels by half and to increase ThMP levels 5-fold, implying that the THIAMIN REQUIRING2 (TH2) gene product could be a dedicated ThMP phosphatase. Genomic and transcriptomic data indicated that TH2 corresponds to At5g32470, encoding a HAD (haloacid dehalogenase) family phosphatase fused to a TenA (thiamin salvage) family protein.

The epidemiology of subclinical malaria infections in South-East Asia: findings from cross-sectional surveys in Thailand-Myanmar border areas, Cambodia, and Vietnam.

Background: The importance of the submicroscopic reservoir of Plasmodium infections for malaria elimination depends on its size, which is generally considered small in low transmission settings. The precise estimation of this reservoir requires more sensitive parasite detection methods. The prevalence of asymptomatic, sub-microscopic malaria was assessed by a sensitive, high blood volume quantitative real-time polymerase chain reaction method in three countries of the Greater Mekong Sub-region.

Arabidopsis and maize RidA proteins preempt reactive enamine/imine damage to branched-chain amino acid biosynthesis in plastids.

RidA (for Reactive Intermediate Deaminase A) proteins are ubiquitous, yet their function in eukaryotes is unclear. It is known that deleting Salmonella enterica ridA causes Ser sensitivity and that S. enterica RidA and its homologs from other organisms hydrolyze the enamine/imine intermediates that Thr dehydratase forms from Ser or Thr.

Prevalence and correlates of zinc deficiency in pregnant Vietnamese women in Ho Chi Minh City.

Background: Although Vietnam is a region with a plant-based diet that has a high zinc deficiency, epidemiological data showing how this affects pregnant women are limited. This study explores the prevalence of zinc deficiency and possible correlates in pregnant Vietnamese women in Ho Chi Minh City.

Methods: This was a cross-sectional study conducted at a general hospital in Ho Chi Minh City, Vietnam.

A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae.

Background: Efficient mechanisms for rejoining of DNA double-strand breaks (DSBs) are vital because misrepair of such lesions leads to mutation, aneuploidy and loss of cell viability. DSB repair is mediated by proteins acting in two major pathways, called homologous recombination and nonhomologous end-joining. Repair efficiency is also modulated by other processes such as sister chromatid cohesion, nucleosome remodeling and DNA damage checkpoints.