Publications by authors named "Thuy Ha Vu"
Article Synopsis
- Intrauterine infection (IUI) involves pathogens ascending from the vagina and cervix to the uterus, affecting the fetus, but effective diagnostic biomarkers for related conditions like chorioamnionitis (CAM) and funisitis (FUN) are lacking.
- A study analyzed the role of specific RNA editing molecules, particularly ADAR1, in tissue samples from 83 patients, finding that ADAR1 showed higher diagnostic capability compared to other markers.
- Ureaplasma parvum was found to activate ADAR1 in a cell line study, while high levels of ADAR1 expression were significantly linked to CAM and FUN cases, suggesting it could serve as a potential diagnostic target for IUI.*
This study investigated the correlation of Apolipoprotein-B mRNA-editing complex 3B (APOBEC3B) expression with hypoxia inducible factor 1α (HIF-1α), Kirsten rat sarcoma virus (KRAS) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in endometriosis patients, and the inhibitory effects of APOBEC3B knockdown in a human endometriotic cell line. Here, APOBEC3B, HIF-1α, KRAS, and PIK3CA were examined in patients with and without endometriosis using reverse transcription polymerase chain reaction (RT-PCR). The apoptosis, cell proliferation, invasion, migration, and biological function of APOBEC3B knockdown were explored in 12Z immortalized human endometriotic cell line.
View Article and Find Full Text PDFBackground/aim: Adenosine deaminase family acting on RNA 1 (ADAR1) expression was examined to determine its correlation with endometriosis. The biological functions and inhibitory effects of ADAR1 knockdown were investigated in a human endometriotic cell line.
Materials And Methods: ADAR1 was examined in patients with and without endometriosis using reverse transcription polymerase chain reaction (RT-PCR), and the apoptotic expression of ADAR1 small interfering RNA (siRNA) was confirmed using flow cytometry.