Publications by authors named "Thusitha J Wijethunga"
Leg edema with (S)-amlodipine vs conventional amlodipine given in triple therapy for hypertension: a randomized double blind controlled clinical trial.
Priyadarshani Galappatthy Yasindu C Waniganayake Mohomad I M Sabeer Thusitha J Wijethunga Gamini K S Galappatthy
BMC Cardiovasc Disord
September 2016
Background: Leg edema is a common adverse effect of dihydropyridine Calcium Channel Blockers (CCB) that may need dose reduction or drug withdrawal, adversely affecting the antihypertensive efficacy. Leg edema is reported to occur less often with (S)-amlodipine compared to conventional racemic amlodipine. We aimed to find the incidence of leg edema as a primary outcome and antihypertensive efficacy with (S)-amlodipine compared to conventional amlodipine.
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- An outbreak of leptospirosis in Sri Lanka in 2008 led to high mortality rates, prompting medical staff at the General Hospital, Peradeniya to implement intravenous methylprednisolone (MP) as part of the treatment for severely ill patients.
- A study divided patients into 'pre-MP' and 'MP' periods, using a clinical severity score to evaluate outcomes; 62 patients received MP treatment while 10 patients without MP were also assessed.
- Results showed a significant reduction in the mortality rate from 21.8% in the pre-MP group to 10.7% in the MP group, suggesting that early administration of MP can be beneficial, particularly for severe cases without major comorbid