A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior.

The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we address the possibility that the fundamental unit of brain state could be at the scale of milliseconds and micrometers.

A non-oscillatory, millisecond-scale embedding of brain state provides insight into behavior.

Sleep and wake are understood to be slow, long-lasting processes that span the entire brain. Brain states correlate with many neurophysiological changes, yet the most robust and reliable signature of state is enriched in rhythms between 0.1 and 20 Hz.

A mixed-methods study of the effectiveness and perceptions of a course design institute for health science educators.

Background: Most health care professionals get their start in academics without formal teaching training. As such, institutions encourage participation in opportunities to address gaps in faculty's knowledge of pedagogy and learning theory in order to promote both successful student and patient outcomes. This study aimed to examine the reception of a faculty development program focused on teaching participants the basics of course design.

Predictive biomarkers for response to trametinib in non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer deaths. Current companion diagnostics use driver mutation sequencing to select patients for molecularly targeted agents (MTA), even though most patients lack actionable mutations. These diagnostics utilize static biomarkers, ignoring real-time tumor cell biology.

Functional Profiling of Head and Neck/Esophageal Squamous Cell Carcinoma to Predict Cetuximab Response.

Cetuximab, an epidermal growth factor receptor (EGFR)-targeting antibody, remains the only Food and Drug Administration-approved targeted therapy for squamous cell carcinoma (SCC) of head and neck/esophagus. However, in clinical trials, cetuximab only benefited a subset of patients and frequently caused toxicity. Predicting which patients respond to cetuximab remains unsolved.

Psychiatric Community Crisis Services for Youth.

Each year, increasing numbers of children and families seek care for psychiatric crises; unfortunately, most communities offer limited services to meet these needs. Youth in crisis often present to emergency departments, but may not need or benefit from that level of care. Instead, data reflect improved clinical and financial outcomes when communities offer a continuum of crisis services.

Myositis ossificans circumscripta of the buccinator muscle: first report of a rare complication of mandibular third molar extraction.

Myositis ossificans is a self-limiting ossifying process that most often develops following mechanical trauma to skeletal musculature. It chiefly affects the skeletal muscles of extremities of young athletically active adult males. Myositis ossificans is rare in children except for children affected by heritable disorder known as progressive myositis ossificans (fibrodysplasia ossificans progressiva).

Interoperability of a mobile health care solution with electronic healthcare record systems.

Mobile health care solutions involving patient monitoring are an increasingly accepted element in chronic disease management strategies. When used in healthcare systems with different providers, it is essential that the information gathered from the patient is available at each of these providers information repositories. This paper describes the design of a connectivity interface based on the HL7 standard that allows the MOTOHEALTH mobile health care solution to communicate with external electronic healthcare record systems supporting HL7.

Benefits and challenges of research with the oldest old for participants and nurses.

The Klamath Exceptional Aging Project is a longitudinal aging study of people 85 and over, the "oldest old," in rural Oregon. Although conducting research with those 85 and over can be challenging, it is increasingly more important that this group be included in research studies given their importance in society. Benefits for the oldest old participating in research include an opportunity for altruism, productivity, and generativity and the expression of power and control.

The viral transactivator E1A regulates the mouse mammary tumor virus promoter in an isoform- and chromatin-specific manner.

Proteins encoded by the adenovirus E1A gene regulate both cellular and viral genes to mediate effects on cell cycle, differentiation, and cell growth control. We have identified the mouse mammary tumor virus (MMTV) promoter as a target of E1A action and investigated the role nucleoprotein structure plays in its response to E1A. Both 12 and 13 S forms target the MMTV promoter when it has a disorganized and accessible chromatin configuration.

What are the facts concerning the number of residency positions in Canada?

Some physicians think the current squeeze facing postgraduate medical education was caused by cuts in the number of residency positions. The authors consulted the Canadian Post-MD Education Registry database to determine the actual state of postgraduate training opportunities and to correct erroneous views that may be affecting the debate over training positions. The danger, they say, is that misinformation may lead to inappropriate strategies for dealing with current challenges.

Relation of cardiovascular responses to mental stress and cardiac vagal activity in coronary artery disease.

Forty-six patients with documented coronary artery disease were studied to examine the relation of cardiovascular reactivity to mental stress and cardiac vagal activity. Cardiac vagal activity was measured by means of frequency-domain analysis of heart rate variability with 48-hour out-of-hospital Holter monitoring. The amplitude of the high-frequency component (0.

Tetanus: an uncommon cause of dysphagia.

A 53-year-old woman was examined at our medical center because of progressive dysphagia of 14 days' duration and a severe inability to open her mouth and swallow saliva. A barium esophagogram showed no obstruction, but pooling of barium in the hypopharynx suggested a neuromuscular disorder. The clinical diagnosis of tetanus was confirmed by electromyography.

Tetanus after anorectal abscess.

As illustrated by this case report, tetanus can occur as a complication of anorectal surgical procedures or abscesses just as it can in other wounds. A synergistic infection of the perineum occurred in a 62-year-old man 8 days after drainage of an anorectal abscess. He was treated with vigorous debridement and antibiotics and was given tetanus prophylaxis.

Milankovitch hypothesis supported by precise dating of coral reefs and deep-sea sediments.

Barbados provides a possibly unique opportunity for reconstruction of the times and elevations of late-Pleistocene high stands of the sea. The island appears to be rising from the sea at a uniform rate that is fast enough to separate in elevation coral-reef tracts formed at successive high stands of the sea. Unaltered coral found in the lower terraces enables high-precision Th(230): U(234) and Pa(231): U(235) dating.

Pleistocene age determinations from california and Oregon.

Mollusks have been collected from Pleistocene marine deposits at Tomales Bay, California, and Cape Blanco, Oregon. Dating by the carbon-14 and thorium-230-uranium-234 methods suggests that the shells are at least 33,000 years old. The more probable age of the Tomales Bay locality is >/= 50,000 years.

Uranium-Series Dating of Corals and Oolites from Bahaman and Florida Key Limestones.

Samples of fossil coral and oolite from marine formations of the Bahamas and the Florida Keys have been analyzed for their concentrations of uranium and thorium isotopes. Ages calculated from the ratio Th(230): U(234) clearly indicate periods of marine limestone formation at about 85,000, 130,000, and 190,000 years ago, implying that the surface of the ocean was then close to its present level.

Uranium-Series Ages of Pacific Atoll Coral.

The thorium-230: uranium-234 method of dating corals and oolites has been evaluated in detail for reliability, and various criteria have been established. Reliable ages for extensive coral formations of about 6000 and 120,000 years were obtained. A hiatus in the development of coral between 6000 and 120,000 years ago on the Pactfic atoll of Eniwetok implies that conditions did not permit coral growth during this period.