TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages.

The RNA binding protein TIA1 is known to regulate stress responses. Here we show that TIA1 plays a much broader role in inflammatory cells, being required for the microglial sensome. We crossed TIA1 cKO mice (using a CX3CR1 driven cre element) to PS19 MAPT P301S tauopathy mice.

Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital.

Introduction: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam.

Methods: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positive Realtime RT-PCR SARS-CoV-2 result and treated at COVID-19 department for at least 72 h were included.

Rapid HIV testing and obstetrical characteristics of women with unknown HIV serostatus at time of labor and delivery.

Objective: To describe the obstetrical characteristics of women without prenatal care and/or undocumented human immunodeficiency virus (HIV) serostatus who presented for delivery and to assess the usefulness of rapid HIV screening in these women.

Materials And Methods: The study design was a retrospective analysis. Demographics, labor, delivery characteristics, and pregnancy outcomes of women without prenatal care and/or unknown HIV serostatus were reviewed.

Preterm birth after mature fetal lung indices: is there any neonatal morbidity?

Objective: To determine the frequency of immediate morbidities in neonates with evidence of mature fetal lung indices who delivered before 37 weeks gestation.

Methods: A retrospective analysis was performed on pregnancies resulting in birth at < 37 weeks after mature fetal lung was documented by phosphatidylglycerol, lecithin/sphingomyelin ratio, or TDx-FLM studies. Pregnancies with multifetal gestations, maternal diabetes, or fetal anomalies were excluded.

Pregnancy outcomes following placement of elective, urgent and emergent cerclage.

Objective: To describe pregnancy outcomes following elective (history-indicated), urgent (ultrasound-indicated) or emergent (physical-exam indicated) cerclage placement.

Materials And Methods: Study design was retrospective chart review. Women with singleton gestation and cervical cerclage were categorised into: elective, urgent and emergent group.

Hemorrhagic stroke after spinal anesthesia and minor surgery.

This report describes a case of hemorrhagic stroke that presented as an expressive aphasia after routine hernia repair under spinal anesthesia in an otherwise generally healthy middle-aged outpatient. Possible roles of preexisting migrainous headaches and perioperative ephedrine are discussed, but, as in most cases of perioperative stroke, the possibilities are numerous and the cause of the stroke difficult to determine.