Publications by authors named "Thu-Ha T Nguyen"

Article Synopsis
  • Gastric ulcers, a widespread gastrointestinal issue, may be caused by the excessive production of reactive oxygen species (ROS), which leads to oxidative stress.
  • The study developed two types of redox nanoparticles (RNPs): one that disintegrates in acidic conditions and one that remains stable, both designed to scavenge ROS for treating gastric ulcers.
  • The RNP showed improved gastric retention and better antioxidant activity under acidic pH compared to the stable RNP, highlighting its potential as a safe and effective oral treatment for gastric ulcers.
View Article and Find Full Text PDF

Pinostrobin demonstrated anticancer properties, but its hydrophobic feature led to a reduction in bioavailability. The mitochondria-targeted approach successfully synthesized eight new alkyl triphenylphosphonium pinostrobin derivatives (1-8) with good yield in this study. Seven compounds (1-3, 5-8) showed greater cytotoxic potency against the human MCF-7 breast cancer cell line than pinostrobin.

View Article and Find Full Text PDF

This study presents a phytochemical analysis of the leaves of , revealing the isolation of a new apotirucallane-type protolimonoid, identified as 25--methyl-1,2-dihydroprotoxylocarpin D (), along with two known compounds ( and ). The known compounds were identified as (20,21,23)-21,23-epoxy-7,24,25-trihydroxy-21--methyl-3-oxoapotirucalla-14-ene () and 7,24,25-trihydroxy-3-oxoapotirucalla-14-en-21,23-olide (). The three apotirucallane-type protolimonoids (-) did not exhibit cytotoxicity against MCF-7 cells at a concentration of 100 µM.

View Article and Find Full Text PDF

Background And Purpose: The utilization of doxorubicin (DOX) in clinal trials is also challenging owing to its adverse effects, including low oral bioavailability, generation of reactive oxygen species (ROS), cardiotoxicity, and epithelial barrier damage. Recently, scavenging of ROS reduced the cytotoxicity of DOX, suggesting a new approach for using DOX as an anticancer treatment. Thus, in this study, non-silica and silica redox nanoparticles (denoted as RNP and siRNP, respectively) with ROS scavenging features have been designed to encapsulate DOX and reduce its cytotoxicity.

View Article and Find Full Text PDF

Sepsis is characterized by an initial net hyperinflammatory response, followed by a period of immunosuppression, termed immunoparalysis. During this immunosuppressive phase, patients may have difficulty eradicating invading pathogens and are susceptible to life-threatening secondary hospital-acquired infections. Due to progress in antimicrobial treatment and supportive care, most patients survive early sepsis.

View Article and Find Full Text PDF
Article Synopsis
  • Biodegradable periodic mesoporous organosilica nanoparticles (B-PMO) are highlighted as effective nanocarriers because of their ability to biodegrade and their capacity to carry high amounts of drugs.
  • The study focuses on a specific type of B-PMO, named P4S, which incorporates phenylene groups that enhance interactions with cordycepin, resulting in slow drug release and prolonged nanoparticle stability.
  • The P4S nanoparticles not only showed excellent biodegradability—completely breaking down in 14 days—but also demonstrated effective drug delivery, targeting liver cancer cells without significantly harming normal cells.
View Article and Find Full Text PDF
Article Synopsis
  • Chronic inflammatory diseases like inflammatory bowel diseases (IBD) are increasingly concerning due to excessive reactive oxygen species (ROS) production affecting health.
  • This study introduces silica-containing redox nanoparticles (siRNP) designed to enhance the bioavailability of silymarin, improving its absorption and targeted delivery to the colon.
  • Silymarin-loaded siRNP (SM@siRNP) showed significant antioxidant and anti-inflammatory effects in lab tests, facilitating improved treatment outcomes for colitis in mice, suggesting strong potential for IBD therapy.
View Article and Find Full Text PDF

In recent years, rapid progress in the field of single-entity electrochemistry (SEE) has opened a novel exploratory area in the field of analytical and electrochemistry. SEE is a method of studying the behavior of particles at the single particle level, which yields important information on the diffusion coefficient, individual particle size, size distribution, catalytic activity, collision frequency, and internal substances of the particles. Various types of particles have been studied through SEE.

View Article and Find Full Text PDF

Severe sepsis and septic shock caused mainly by bacterial infections are life-threatening conditions that urge the development of novel therapies. However, host responses to and pathophysiology of sepsis have not been clearly understood, which remains a major obstacle for the development of effective therapeutics. Recently, we have shown that stimulation of a costimulatory molecule, CD137, enhanced survival of mice infected with the Gram-positive (G(+)) intracellular bacterium Listeria monocytogenes but decreased survival in a polymicrobial sepsis model.

View Article and Find Full Text PDF