Publications by authors named "Thu Truong"
Introduction: Exosomes are extracellular vesicles that transport bioactive substances during normal and abnormal cellular physiological processes. The unique properties of exosomes can be exploited for use as biomarkers and targeted drug delivery vehicles, and are, for this reason, gaining increasing attention in the field of dermatology. This review aims to synthesise the existing evidence supporting exosomes in regenerative and cosmetic dermatology.
View Article and Find Full Text PDFUnderstanding how natural and engineered peptides enter cells would facilitate the elucidation of biochemical mechanisms underlying cell biology and is pivotal for developing effective intracellular targeting strategies. In this study, we demonstrate that our peptide stapling technique, fluorine-thiol displacement reaction (FTDR), can produce flexibly constrained peptides with significantly improved cellular uptake, particularly into the nucleus. This platform confers enhanced flexibility, which is further amplified by the inclusion of a D-amino acid, while maintaining environment-dependent α helicity, resulting in highly permeable peptides without the need for additional cell-penetrating motifs.
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- - Pemphigus is a serious autoimmune blistering disease that significantly impacts patients' health and quality of life, prompting numerous clinical trials to explore effective treatments.
- - A review of 53 randomized clinical trials showed that the Pemphigus Disease Area Index is the most commonly used disease severity measure, particularly gaining traction after 2015, while less popular methods have declined.
- - There's a growing trend toward including Quality of Life (QoL) measurements in clinical trials, although only a quarter currently assess it; standardizing these measures can improve data interpretation and clinical relevance over time.
Breast cancer progression involves intricate interactions between cancer cells and the tumor microenvironment (TME). This study elucidates the critical role of progesterone receptor (PR) signaling in mediating the protumorigenic effects of cancer-associated fibroblasts (CAFs) on estrogen receptor-positive (ER+) luminal breast cancer cells. We demonstrate that CAFs produce physiologically relevant levels of estrogen and progesterone, which significantly contribute to breast cancer tumorigenicity.
View Article and Find Full Text PDFSustainable cellulose-based hydrogels are used in medicine and environmental science. Hydrogels' porosity makes them excellent adsorbents and stable substrates for immobilizing photocatalysts to remove organic dyes. Despite their potential, the implementation of hydrogels for this purpose is still limited due to their high synthesis temperature and low cellulose content.
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- The study investigated the effectiveness of hydradermabrasion (or HydraFacial) in rejuvenating skin using a non-invasive imaging technique called Line-Field Confocal Optical Coherence Tomography (LC-OCT).* -
- Eight volunteers underwent the treatment, with imaging taken before, immediately after, and two weeks post-treatment, showing changes in the epidermis and dermis, including variations in thickness and texture.* -
- The results indicated that hydradermabrasion effectively altered skin structure, as shown by LC-OCT images, proving its efficacy and demonstrating LC-OCT's potential for analyzing cosmetic procedures.*
Article Synopsis
- Microdermabrasion is a cosmetic procedure that promotes skin rejuvenation by inducing controlled injuries to the skin, leading to increased collagen and fibroblast production.
- This study used line-field confocal optical coherence tomography (LC-OCT) to examine the microscopic effects of microdermabrasion on the skin's structure, specifically looking at epidermal thickness and collagen patterns.
- Results showed decreased stratum corneum thickness and improved collagen visibility post-treatment, indicating that LC-OCT can effectively monitor skin changes over time alongside clinical improvements.
Article Synopsis
- AI technology is being widely used in dermatology for assessing and diagnosing skin conditions, utilizing algorithms and language models to mimic human problem-solving.
- A literature review highlighted challenges faced by AI programs, particularly their difficulty in accurately identifying skin lesions in skin of color (SOC) due to underrepresentation in data sets.
- Only 30% of existing programs reported effectiveness in SOC, indicating a need for improved image quality and more inclusive datasets for better AI performance in dermatology.
Article Synopsis
- - Port-wine stains (PWS) are treated with pulsed-dye laser (PDL), but their effectiveness can be limited by revascularization; sirolimus (SIRO) may help counteract this issue.
- - A systematic review of studies from 2000 to 2023 analyzed the effects of combining SIRO with PDL for PWS treatment, involving nine studies with a total of 58 patients.
- - While some studies showed improved treatment parameters with the combination therapy, inconsistencies among the studies indicate a need for more extensive research and standardized evaluation to confirm safety and effectiveness.
Article Synopsis
- - Scleredema diabeticorum (SD) is a frequent condition linked to diabetes, but treatment options are often limited and not very effective.
- - Patients with SD can suffer from troubling symptoms, including itching, burning sensations, and pain, which can significantly affect their comfort.
- - The development of SD is often associated with poor blood sugar management, as illustrated in the specific case mentioned.
Staining is a crucial step in histopathology that prepares tissue sections for microscopic examination. Hematoxylin and eosin (H&E) staining, also known as basic or routine staining, is used in 80% of histopathology slides worldwide. To enhance the histopathology workflow, recent research has focused on integrating generative artificial intelligence and deep learning models.
View Article and Find Full Text PDFMultiple recently approved medications have been added to our treatment armamentarium for various dermatologic conditions. Herein, we have reviewed the literature, consolidated available safety data, and offered recommendations based upon available evidence as a reference guide for clinicians treating patients for dermatologic conditions during lactation.
View Article and Find Full Text PDFThe breadth of therapeutic options for the management of dermatologic skin conditions continues to expand rapidly as exemplified by biologics and small molecule drug development. While dermatologists and health care providers are aware of the underlying mechanisms and indications for these therapeutics, there is a recognized practice gap due to an incomplete understanding of the safety of these medications in women of childbearing age during the prepartum, antepartum, and postpartum phases. Although a two-part continuing medical education review was published regarding the prescribing practices and safety profiles of these new therapeutics in women of childbearing age while pregnant or lactating in 2014, many new medications have been approved since then.
View Article and Find Full Text PDFPorokeratosis is a rare group of acquired or hereditary dermatoses characterized by linear or annular plaques with a keratotic border. DSAP is the most common porokeratosis, and lesions range from asymptomatic to pruritic circular pink to brown macules, papules, or plaques surrounded by a raised border. DSAP carries about 7.
View Article and Find Full Text PDFKey Clinical Message: For practitioners experiencing worsening psoriasis, subacute cutaneous lupus erythematosus (SCLE) with a psoriasiform presentation should be ruled out. Initial treatment for a presumptive diagnosis of psoriasis using hydroxychloroquine or ultraviolet phototherapy may cause SCLE to worsen.
Abstract: Psoriasiform subacute cutaneous lupus erythematosus is an unusual presentation scarcely reported in literature.