Intracerebral inoculation of healthy non-transgenic rats with a single aliquot of oligomeric amyloid-β (1-42) profoundly and progressively alters brain function throughout life.

One of the puzzling aspects of sporadic Alzheimer's disease (AD) is how it commences. Changes in one key brain peptide, amyloid-beta (Aβ), accompany disease progression, but whether this comprises a trigger or a consequence of AD is still a topic of debate. It is clear however that the cerebral presence of oligomeric Aβ (1-42) is a key factor in early AD-pathogenesis.

Estimating ammonium changes in pilot and full-scale constructed wetlands using kinetic model, linear regression, and machine learning.

Constructed wetlands (CWs) are a widely utilized nature-based wastewater treatment method for various effluents. However, their application has been more focused on pilot and full-scale CWs with substantial surface areas and extended operation times, which hold greater relevance in practical scenarios. This study used kinetics, linear regression (LR), and machine learning (ML) models to estimate effluent ammonium in pilot and full-scale CWs.

Challenges to Accurate Estimation of Methane Emission from Septic Tanks with Long Emptying Intervals.

Septic tanks in low- and middle-income countries are often not emptied for a long time, potentially resulting in poor pollutant removal efficiency and increased greenhouse gas emissions, including methane (CH). We examined the impact of long emptying intervals (4.0-23 years) on the biochemical oxygen demand (BOD) removal efficiency of 15 blackwater septic tanks and the CH emission rates of 23 blackwater septic tanks in Hanoi.

Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning.

Hippocampal afferent inputs, terminating on proximal and distal subfields of the cornus ammonis (CA), enable the functional discrimination of 'what' (item identity) and 'where' (spatial location) elements of a spatial representation. This kind of information is supported by structures such as the retrosplenial cortex (RSC). Spatial content learning promotes the expression of hippocampal synaptic plasticity, particularly long-term depression (LTD).

Improving algal bloom detection using spectroscopic analysis and machine learning: A case study in a large artificial reservoir, South Korea.

The prediction of algal blooms using traditional water quality indicators is expensive, labor-intensive, and time-consuming, making it challenging to meet the critical requirement of timely monitoring for prompt management. Using optical measures for forecasting algal blooms is a feasible and useful method to overcome these problems. This study explores the potential application of optical measures to enhance algal bloom prediction in terms of prediction accuracy and workload reduction, aided by machine learning (ML) models.

The Perirhinal Cortex Engages in Area and Layer-Specific Encoding of Item Dimensions.

The perirhinal cortex (PRC), subdivided into areas 35 and 36, belongs to the parahippocampal regions that provide polysensory input to the hippocampus. Efferent and afferent connections along its rostro-caudal axis, and of areas 35 and 36, are extremely diverse. Correspondingly functional tasks in which the PRC participates are manifold.

Application and validation of a biotic ligand model for calculating acute toxicity of lead to Moina dubia in lakes of Hanoi, Vietnam.

It is increasingly being recognized that biotic ligand models (BLMs) can successfully predict the toxicity of divalent metals toward aquatic biota applied to temperate freshwater ecosystems. However, studies on the eutrophic lakes in tropical regions toward native tropical organisms, including Moina, are relatively limited. In this study, Moina dubia, the native organism of the Hanoi eutrophic urban lakes, were used in toxicological studies of lead (Pb); 24-h EC value of Pb was 523.

Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination.

The olfactory bulb (OB) delivers sensory information to the piriform cortex (PC) and other components of the olfactory system. OB-PC synapses have been reported to express short-lasting forms of synaptic plasticity, whereas long-term potentiation (LTP) of the anterior PC (aPC) occurs predominantly by activating inputs from the prefrontal cortex. This suggests that brain regions outside the olfactory system may contribute to olfactory information processing and storage.

Application of Machine Learning for eutrophication analysis and algal bloom prediction in an urban river: A 10-year study of the Han River, South Korea.

The increasing release of nutrients to aquatic environments has led to great concern regarding eutrophication and the risk of unwanted algal blooms. Based on observational data of 20 water quality parameters measured on a monthly basis at 40 stations from 2011 to 2020, this study applied different Machine Learning (ML) algorithms to suggest the best option for algal bloom prediction in the Han River, a large river in South Korea. Eight different ML algorithms were categorized into several groups of statistical learning, regression family, and deep learning, and were then compared for their suitability to predict the chlorophyll-derived trophic index (TSI-Chla).

Hippocampal subfield-specific Homer1a expression is triggered by learning-facilitated long-term potentiation and long-term depression at medial perforant path synapses.

Learning about general aspects, or content details, of space results in differentiated neuronal information encoding within the proximodistal axis of the hippocampus. These processes are tightly linked to long-term potentiation (LTP) and long-term depression (LTD). Here, we explored the precise sites of encoding of synaptic plasticity in the hippocampus that are mediated by information throughput from the perforant path.

Reversible and irreversible transgenerational effects of metal exposure on nine generations of a tropical micro-crustacean.

Micro-crustaceans are important grazers that control the algal blooms in eutrophic lakes. However, we know little about how these key species may be affected by long-term exposure to contaminants and when the transgenerational effects are reversible and irreversible. To address this, we investigated the effects of lead (Pb, 100 μg L) exposure on morphology and reproduction of Moina dubia for nine consecutive generations (F1-F9) in three treatments: control, Pb, and pPb (M.

Greenhouse Gas Emissions from Blackwater Septic Systems.

Septic systems are potentially a significant source of greenhouse gases (GHGs). The present study investigated GHGs from the blackwater septic systems that are widely used especially in low- and middle-income countries. Ten blackwater septic tanks in Hanoi, Vietnam, were investigated using the floating chamber method.

Involvement of the Postrhinal and Perirhinal Cortices in Microscale and Macroscale Visuospatial Information Encoding.

Whereas the postrhinal cortex (POR) is a critical center for the integration of egocentric and allocentric spatial information, the perirhinal cortex (PRC) plays an important role in the encoding of objects that supports spatial learning. The POR and PRC send afferents to the hippocampus, a structure that builds complex associative memories from the spatial experience. Hippocampal encoding of item-place experience is accompanied by the nuclear expression of immediate early gene (IEGs).

Novel encoding and updating of positional, or directional, spatial cues are processed by distinct hippocampal subfields: Evidence for parallel information processing and the "what" stream.

The specific roles of hippocampal subfields in spatial information processing and encoding are, as yet, unclear. The parallel map theory postulates that whereas the CA1 processes discrete environmental features (positional cues used to generate a "sketch map"), the dentate gyrus (DG) processes large navigation-relevant landmarks (directional cues used to generate a "bearing map"). Additionally, the two-streams hypothesis suggests that hippocampal subfields engage in differentiated processing of information from the "where" and the "what" streams.

Comparison of the abiotic preferences of macroinvertebrates in tropical river basins.

We assessed and compared abiotic preferences of aquatic macroinvertebrates in three river basins located in Ecuador, Ethiopia and Vietnam. Upon using logistic regression models we analyzed the relationship between the probability of occurrence of five macroinvertebrate families, ranging from pollution tolerant to pollution sensitive, (Chironomidae, Baetidae, Hydroptilidae, Libellulidae and Leptophlebiidae) and physical-chemical water quality conditions. Within the investigated physical-chemical ranges, nine out of twenty-five interaction effects were significant.

Integrating data-driven ecological models in an expert-based decision support system for water management in the Du river basin (Vietnam).

In this study, classification trees were combined with the Water Framework Directive (WFD)-Explorer, a modular toolbox that supports integrated water management in a river basin to evaluate the impact of different restoration measures on river ecology. First, the WFD-Explorer toolbox analysed the effect of different restoration options on the abiotic river characteristics based on the water and substance balance embedded in the simulation environment. Based on these abiotic characteristics, the biological index Biological Monitoring Working Party for Vietnam was then predicted by classification trees that were trained on biological and abiotic data collected in the Du river basin in northern Vietnam.