Publications by authors named "Thu Hien Vu"
Despite ongoing antibiotic development, evolution of resistance may render candidate antibiotics ineffective. Here we studied in vitro emergence of resistance to 13 antibiotics introduced after 2017 or currently in development, compared with in-use antibiotics. Laboratory evolution showed that clinically relevant resistance arises within 60 days of antibiotic exposure in Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa, priority Gram-negative ESKAPE pathogens.
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- A new series of benzothiazole inhibitors targeting bacterial DNA gyrase and topoisomerase IV were created, displaying strong antibacterial effects against various Gram-positive and multi-drug resistant strains.
- The best compounds exhibited minimal inhibitory concentrations (MICs) between <0.03125-0.25 μg/mL for Gram-positive bacteria and 1-4 μg/mL for Gram-negative bacteria.
- One lead compound was found to have favorable properties, including good solubility, metabolic stability, and selectivity for bacterial topoisomerases, and showed effective in vivo results against vancomycin-intermediate thigh infections in a mouse model.
Objective: To determine the prevalence of and associated factors for overweight, especially to determine the relationship between the intake of monosodium glutamate (MSG) as a seasoning and overweight in Vietnam.
Design: A cross-sectional survey was conducted of Vietnamese adults aged ≥20 years in 2008. Dietary intake was assessed by the 24 h recall method for 3 d.