Knee Bone Models From Ultrasound.

The number of total knee arthroplasties performed worldwide is on the rise. Patient-specific planning and implants may improve surgical outcomes but require 3-D models of the bones involved. Ultrasound (US) may become a cheap and nonharmful imaging modality if the shortcomings of segmentation techniques in terms of automation, accuracy, and robustness are overcome; furthermore, any kind of US-based bone reconstruction must involve some kind of model completion to handle occluded areas, for example, the frontal femur.

Neuron loss during early adulthood following prenatal low-dose X-irradiation in the mouse brain.

Purpose: Apart from subsequent cell death, little is known about long-term effects of a prenatal low-dose X-irradiation (PLDI) on nuclear (n) and mitochondrial (mt) DNA, and whether these effects are connected with reduced neuron numbers in the adult brain.

Materials And Methods: Pregnant mice were X-irradiated with 0, 10 or 50cGy at day 13 (E13) of pregnancy. One day after (E14), or postnatally at day 25 (P25) or P180, the brains of the offspring were analysed concerning the extent of nDNA repair, mt biogenesis, and the relative content of nDNA single strand breaks (SSB).