Complete Genome Sequence and Manual Reannotation of Mycobacterium avium subsp. Strain DSM 44135.

Here, we report the complete genome sequence of the subsp. reference strain DSM 44135, amended with a manual genome reannotation. The strain was originally described as strain 6783.

FurA contributes to the oxidative stress response regulation of Mycobacterium avium ssp. paratuberculosis.

The ferric uptake regulator A (FurA) is known to be involved in iron homeostasis and stress response in many bacteria. In mycobacteria the precise role of FurA is still unclear. In the presented study, we addressed the functional role of FurA in the ruminant pathogen Mycobacterium avium ssp.

The Mycobacterium avium ssp. paratuberculosis specific mptD gene is required for maintenance of the metabolic homeostasis necessary for full virulence in mouse infections.

Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease, a chronic granulomatous enteritis in ruminants. Furthermore, infections of humans with MAP have been reported and a possible association with Crohn's disease and diabetes type I is currently discussed. MAP owns large sequence polymorphisms (LSPs) that were exclusively found in this mycobacteria species.