Small dense LDL particles--a predictor of coronary artery disease evaluated by invasive and CT-based techniques: a case-control study.

Background: Coronary angiography is the current standard method to evaluate coronary atherosclerosis in patients with suspected angina pectoris, but non-invasive CT scanning of the coronaries are increasingly used for the same purpose. Low-density lipoprotein (LDL) cholesterol and other lipid and lipoprotein variables are major risk factors for coronary artery disease. Small dense LDL particles may be of particular importance, but clinical studies evaluating their predictive value for coronary atherosclerosis are few.

[Detection of stenoses in the coronary arteries using 64-slice computed tomography].

Introduction: The purpose of the present study was to assess the diagnostic value of 64-slice computed tomography of the coronary arteries (CTCA) with invasive coronary angiography (CA) as reference.

Material And Methods: We studied 194 patients (mean age: 62.7 ± 9.

[Preoperative functional magnetic resonance imaging in patients with brain tumors].

Introduction: Functional Magnetic Resonance Imaging (fMRI) allows important functions in the brain cortex to be mapped noninvasively. The purpose with this work was to investigate a possible correlation between the distance from the tumour margin to fMRI activity and postoperative neurological deficits by means of a standardised method for measurement of distance. A second purpose was to investigate the influence of preoperative fMRI on the neurosurgical decision-making process.

Aicardi-Goutières syndrome: neuroradiological findings after nine years of follow-up.

The main radiological features of Aicardi-Goutières syndrome include basal ganglia calcification, cerebral atrophy and white matter alterations. We present a case where progress of cerebral calcifications demonstrated on consecutive CT-scans later on was followed by a decrease. The MRI showed a progressive and significant loss of white matter and severe signal changes of the remaining myelin.

Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: indication of close relation between myocardial iron content and chelatable iron pool.

Evaluation of myocardial iron during iron chelation therapy is not feasible by repeated endomyocardial biopsies owing to the heterogeneity of iron distribution and the risk of complications. Recently, we described a noninvasive method based on magnetic resonance imaging. Here, the method was used for repeated estimation of the myocardial iron content during iron chelation with deferrioxamine in 14 adult nonthalassemic patients with transfusional iron overload.

Relationship between hepatocellular injury and transfusional iron overload prior to and during iron chelation with desferrioxamine: a study in adult patients with acquired anemias.

The role of iron overload as cause of liver dysfunction has never been studied in detail in patients without concomitant hepatotropic infections who receive multiple transfusions. We therefore investigated the relationship between the extent of hepatocellular injury as reflected by serum levels of aminotransferases (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and several iron status indices in 39 anti-hepatitis C virus-negative (HCV(-)) nonthalassemic patients with transfusional iron overload owing to acquired anemias. In 12 patients, we monitored aminotransferase levels and indices of iron status during iron chelation treatment.

[MR scanning of cerebrum in the investigation of delayed development in children. Syntelencephaly--is it really so rare?].

A 14-month-old boy presented with a mild global developmental delay, plagiocephaly, and a mild mid-face dysmorphology, including hypertelorism. At 24 months of age, early signs of a spastic diplegic cerebral palsy were noted. MRI of the brain showed middle interhemispheric fusion: syntelencephaly.