Relationship between F-18 florbetapir uptake in occipital lobe and neurocognitive performance in Alzheimer's disease.

Purpose: To determine the association between occipital amyloid-PET uptake and neurocognitive performance in Alzheimer's disease (AD).

Materials And Methods: Fifty-eight participants with normal aged, mild cognitive impairment (MCI) due to AD and AD subjects who underwent F-18 florbetapir brain PET/CT scans were divided into four groups (A, normal; B, MCI; C, mild AD; and D, moderate/severe AD). Semiquantitative analyses of SUVR images were performed.

Head-to-head comparison of [F]-fluorodeoxyglucose and [F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series.

We report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [F]-2'-fluoro-2'-deoxy-D-glucose ([F]-FDG) and [F]-fluorocholine ([F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare pregnancy-related disorder. Whole-body PET/CT with [F]-FDG and [F]-FCH was performed in three patients with GTN in 2 consecutive days. Each detectable lesion was characterized by visual and quantitative analyses.

Relationships between amyloid levels, glucose metabolism, morphologic changes in the brain and clinical status of patients with Alzheimer's disease.

Objective: The current study was conducted to improve the understanding of relationships between regional cortical amyloid load, glucose metabolism, cortical morphology (volume), and severity of clinical symptoms in patients with AD, MCI, and age-matched controls.

Methods: To objectivize the radiological evaluation of patients with suspected AD, head-to-head multi-modality imaging studies were conducted using MRI and PET/CT with [F]FDG and [F]AV45 for visualization and quantitation of brain morphology, glucose metabolism, and amyloid levels, respectively. A total of 84 subjects was studied, including 33 patients with AD, 31 patients with MCI, and 20 age-matched healthy controls (HC).

Effects of point spread function-based image reconstruction on neuroreceptor binding in positron emission tomography study with [(11)C]FLB 457.

The ordered subset expectation maximization with a point spread function (OSEM-PSF) was developed to improve the spatial resolution of reconstructed positron emission tomography (PET) images and has been reported to improve the contrast of hot spots in PET studies for oncology. However, in neuroreceptor imaging, the regional radioactivity concentration changes dynamically during the scan, and the effects of the PSF may differ among various radioligands or quantification methods. In this study, we investigated the effects of the PSF on quantification in PET studies with [(11)C]FLB 457 of dopamine D2 receptors, using both phantom and human data acquired by the Siemens Biograph 16 imaging platform.

Utility of Adding SPECT/CT Imaging to Post-Therapeutic Radioiodine Whole-Body Scan in Patients with Differentiated Thyroid Cancer.

Objective: To determine the usefulness of adding single-photon emission computed tomography/computed tomography (SPECT/CT) imaging to post-therapeutic radioiodine whole-body scan (RxWBS) in patients with differentiated thyroid cancer.

Material And Method: RxWBSs and SPECT/CT images of 93 consecutive patients were reviewed retrospectively by three experienced nuclear medicine physicians without knowledge of clinical data. RxWBSs were reviewed first followed by evaluation of RxWBS plus SPECT/CT imaging.