Putrescine Depletion in Parasites Causes Immediate Proliferation Arrest Followed by an Apoptosis-like Cell Death.

The polyamine pathway in parasites has emerged as a promising target for therapeutic intervention, yet the functions of polyamines in parasites remain largely unexplored. Ornithine decarboxylase (ODC) and spermidine synthase (SPDSYN) catalyze the sequential conversion of ornithine to putrescine and spermidine. We previously found that Δ and Δ mutants exhibit markedly reduced growth in vitro and diminished infectivity in mice, with the effect being most pronounced in putrescine-depleted Δ mutants.

Causal models and prediction in cell line perturbation experiments.

In cell line perturbation experiments, a collection of cells is perturbed with external agents and responses such as protein expression measured. Due to cost constraints, only a small fraction of all possible perturbations can be tested in vitro. This has led to the development of computational models that can predict cellular responses to perturbations in silico.

Influence of alkaline activators on mechanical properties of environmentally friendly geopolymer concrete under different curing regimes.

Previous studies highlighted the significance of tailoring alkaline activators (AA) to specific fly ash (FA) sources for optimal properties of geopolymer concrete (GPC). This study examines the influence of various AA's properties on mechanical properties and microstructures of local low-calcium FA-based GPC under varying curing conditions. A comprehensive investigation consists of several factors such as NaOH molarities (10 M, 12 M, 14 M, 16 M), ratios (1.

Gold-Catalyzed Diyne-Ene Annulation for the Synthesis of Polysubstituted Benzenes through Formal [3+3] Approach with Amide as the Critical Co-Catalyst.

The one-step synthesis of tetra-substituted benzenes was accomplished via gold-catalyzed diyne-ene annulation. Distinguished from prior modification methods, this novel strategy undergoes formal [3+3] cyclization, producing polysubstituted benzenes with exceptional efficiency. The critical factor enabling this transformation was the introduction of amides, which were reported for the first time in gold catalysis as covalent nucleophilic co-catalysts.

Synthesis and crystal structures of three organoplatinum(II) complexes bearing natural aryl-olefin and quinoline derivatives.

Three organoplatinum(II) complexes bearing natural aryl-olefin and quinoline derivatives, namely, [4-meth-oxy-5-(2-meth-oxy-2-oxoeth-oxy)-2-(prop-2-en-1-yl)phen-yl](quinolin-8-olato)platinum(II), [Pt(CHO)(CHNO)], (), [4-meth-oxy-5-(2-oxo-2-propoxyeth-oxy)-2-(prop-2-en-1-yl)phen-yl](quinoline-2-carboxy-l-ato)platinum(II), [Pt(CHO)(CHNO)], (), and chlorido-[4-meth-oxy-5-(2-oxo-2-propoxyeth-oxy)-2-(prop-2-en-1-yl)phen-yl](quinoline)-plat-inum(II), [Pt(CHO)Cl(CHN)], (), were synthesized and structurally characterized by IR and H NMR spectroscopy, and by single-crystal X-ray diffraction. The results showed that the cyclo-platinated aryl-olefin coordinates with Pt the carbon atom of the phenyl ring and the C=C group. The deprotonated 8-hy-droxy-quinoline (CHNO) and quinoline-2-carb-oxy-lic acid (CHNO) coordinate with the Pt atom the N and O atoms in complexes () and () while the quinoline (CHN) coordinates the N atom in ().

Synthesis, crystal structure and anti-cancer activity of the complex chlorido-(η-ethyl-ene)(quinolin-8-olato-κ,)platinum(II) by experimental and theoretical methods.

The complex [Pt(CHNO)Cl(CH)], (I), was synthesized and structurally characterized by ESI mass spectrometry, IR, NMR spectroscopy, DFT calculations and X-ray diffraction. The results showed that the deprotonated 8-hy-droxy-quinoline (CHNO) coordinates with the Pt atom the N and O atoms while the ethyl-ene coordinates in the η manner and in the position compared to the coordinating N atom. The crystal packing is characterized by C-H⋯O, C-H⋯π, Cl⋯π and Pt⋯π inter-actions.

Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and Radiotherapy Planning in Head and Neck Squamous Carcinoma: A Retrospective Study of 46 Patients.

BACKGROUND Positron emission tomography/computed tomography (PET/CT) using fluorodeoxyglucose (FDG) is essential in oncology for precise tumor delineation. This study evaluated FDG PET/CT's impact on therapeutic decisions in head and neck cancer, comparing metabolic tumor volumes (MTV) measured by different methods with radiotherapy targets, crucial for treatment planning and patient outcomes. MATERIAL AND METHODS We retrospectively analyzed 46 patients with histologically confirmed head and neck cancer who underwent FDG PET/CT examination before radiotherapy.

Unusual reaction of ()-2-[(benzo[]thia-zol-2-yl-imino)-meth-yl]-5-(di-ethyl-amino)-phenol with tri-phenyl-borane: crystal structures and optical properties.

The mol-ecular and crystal structure of ()-2-[(benzo[]thia-zol-2-yl-imino)-meth-yl]-5-(di-ethyl-amino)-phenol (CHNOS, ) and its unexpected reaction product with tri-phenyl-borane, 2,2-diphenyl-1,3-dioxa-2-borata-1,2-di-hydro-naphthalene [systematic name: ,-diethyl-2,2-diphenyl-2-1,3λ,2λ-ben-zodioxaborinin-7-amine, CHBNO, ()] are described. For , the hydroxyl group is involved in an intra-molecular hydrogen bond with the imino nitro-gen atom and the C=N bond displays an configuration. The crystal packing is characterized by layers of inversion dimers parallel to the (10) plane and chains of mol-ecule in the -axis direction formed through C-H⋯O inter-actions.

Imidazolium-Based Heavy-Atom-Free Photosensitizer for Nucleus-Targeted Fluorescence Bioimaging and Photodynamic Therapy.

The development of heavy-atom-free photosensitizers (PSs) for photodynamic therapy (PDT) has encountered significant challenges in achieving simultaneous high fluorescence emission and reactive oxygen species (ROS) generation. Moreover, the limited water solubility of these PSs imposes further limitations on their biomedical applications. To overcome these obstacles, this study presents a molecular design strategy employing hydrophilic heavy-atom-free PSs based on imidazolium salts.

Einstein exponential operation laws of spherical fuzzy sets and aggregation operators in decision making.

The spherical fuzzy set (SFS) model is one of the newly developed extensions of fuzzy sets (FS) for the purpose of dealing with uncertainty or vagueness in decision making. The aim of this paper is to define new exponential and Einstein exponential operational laws for spherical fuzzy sets and their corresponding aggregation operators. We introduce the operational laws for exponential and Einstein exponential SFSs in which the base values are crisp numbers and the exponents (weights) are spherical fuzzy numbers.

Rare Complication of Strongyloidiasis in Vietnam: A Case of Venous Thromboembolism and Duodenal Obstruction.

Strongyloidiasis, a chronic helminth infection caused by the parasitic nematode , has various clinical manifestations. Although rare, duodenal obstructions and venous thromboembolism are possible complications of strongyloidiasis. This paper presents the case of a 47-year-old Vietnamese male with a history of right lower limb edema, anorexia, nausea, vomiting, diarrhea, and abdominal discomfort lasting for four months.

Orbital rhabdomyosarcoma in a 19-year-old male patient: A case report and literature review.

Rhabdomyosarcoma (RMS) is the most common mesenchymal tumor in children and adolescents, with 10% of cases occurring in the orbits. RMS should be suspected whenever children present with rapidly progressing unilateral exophthalmos. Its symptoms depend on the lesion's origin and location.

Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.

Background And Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).

Strength, durability, and microstructure of self-compacting geopolymer concrete produced with copper slag aggregates.

Lack of vibrations on fresh concrete negatively influences the compaction and thus the quality of concrete. This is particularly concerning with geopolymer concrete (GPC) containing sodium silicate (NaSiO), which is viscous in nature. In this study, self-compacting geopolymer concrete (SCGC) containing fly ash (FA) and ultrafine slag (UFS) with copper slag aggregates (CSA) was proposed and investigated.

Features of International Publications in Vietnamese Radiological Societies after The Enactment of 37/2018/QĐ-TTg.

Background: In Vietnam, after the enactment of 37/2018/QĐ-TTg, a distinct shift could be observed in the international publications by radiological societies.

Objctive: This study examined trends in the international publications achieved by Vietnamese radiological societies following the enactment of 37/2018/QĐ-TTg.

Methods: This retrospective study evaluated data that are freely accessible and available online and, therefore, did not require institutional review board approval.

A case report describing the successful separation of ischiopagus tetrapus conjoined twins in Vietnam.

Ischiopagus conjoined twinning is a rare congenital defect. The surgical separation of conjoined twins is difficult because of the complex anatomy and physiology. Careful preoperative assessment, planning, and effective surgical teams are critically important for achieving a good outcome.

A case report of pericallosal aneurysm successfully treated with flow diverter stents.

Pericallosal artery aneurysm (PAA) is a relatively uncommon type of intracranial aneurysm that tends to rupture more frequently and cause higher mortality rates than other types of cerebral aneurysms. Surgery to address PAA is difficult due to its deep-seated location, the size of the aneurysmal sac, and the limited surgical field. In recent years, with the development of percutaneous interventions, endovascular treatment has become the preferred, minimally invasive intervention method for the treatment of pericallosal aneurysms.

Multifocal precursor B-cell lymphoblastic lymphoma in an infant with cardiac involvement: A case report.

Lymphoma with cardiac involvement is a high-risk lesion, especially in children. We report a rare clinical case of multifocal precursor B-cell lymphoblastic lymphoma in a child with cardiac involvement. A 4-year-old boy presented to the Vietnam National Children's Hospital with a vague headache, but magnetic resonance imaging of the head was normal.

Cecum perforation due to a fish bone.

Foreign body (FB) ingestion is a common condition encountered in clinical practice, especially among the pediatric age group; however, this occurrence is rare among adults. Some FBs can induce the perforation of the gastrointestinal tract, including fish bones, chicken bones and toothpicks. The ingestion of FBs is rarely associated with bowel perforation, and most FBs are passed spontaneously.

Hypovascular pancreatic neuroendocrine tumor with hepatic metastases: A case report and literature review.

Hypovascular pancreatic neuroendocrine tumors are uncommon pancreatic tumors and commonly misdiagnosed as pancreatic ductal adenocarcinoma or chronic mass-forming pancreatitis. The liver is the organ most commonly affected by neuroendocrine tumor metastases but hepatic neuroendocrine tumor metastases are quite difficult to discriminate from other hepatic metastases and primary hepatic tumors. We describe a case of a 47-year-old man with incidentally detected multiple hepatic lesions on ultrasound.

A rare case of lipomatous pseudohypertrophy of the pancreas.

Lipomatous pseudohypertrophy of the pancreas is a rare disease with unknown etiology, and the pancreas parenchyma is replaced by pancreatic parenchyma by fat tissue. In this article, we aimed to report the case of a 26-year-old male patient admitted to hospital with loss of appetite for 6 months. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) scans showed diffuse enlargement and fatty replacement over the whole pancreas, with scattered remnants of pancreatic parenchyma.