Publications by authors named "Thompho J Rashamuse"

The synthesis of the title compound, [Zn(CHN)](NO), is described. This complex consists of a central zinc metal ion surrounded by six 1-methyl-imidazole ligands, charge balanced by two nitrate anions. The complex crystallizes in the space group .

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Article Synopsis
  • MCRs (multicomponent reactions) have been utilized since their discovery in 1850 and are valued for their efficiency in creating diverse and complex organic molecules.
  • These reactions, including Ugi, Passerini, Biginelli, and Hantzsch, play a crucial role in medicinal chemistry and industrial applications while promoting sustainable practices.
  • Advantages of MCRs include atom economy, recyclable catalysts, reduced waste, and simplification of the synthesis process by combining multiple steps into one.
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We present here the design, synthesis, and photophysical properties of two novel fluorescent zinc (II) complexes, () and (), containing 4-(1-octyl-1-imidazol-4-yl)-,-diphenyl-[1,1-biphenyl]-4-yl)-4-amine and 9-(4-(1-octyl-1-imidazol-4-yl)-[1,1-biphenyl]-4-yl)-9-carbazole ligands. The newly synthesized free ligands and their zinc (II) complexes were characterized using several spectroscopic techniques; their structures were identified by single-crystal X-ray diffraction; and their photophysical properties have been studied in the context of their chemical structure. The () and () complexes showed good thermal stability at 341 °C and 365 °C, respectively.

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Blue emissions in organic light-emitting diodes (OLEDs) are essential for their application in solid-state lighting and full-colour flat panel displays. On the other hand, high-power blue emitters are still uncommon, especially those that can achieve the Commission Internationale de l'Eclairage (CIE, X, Y) coordinates of (0.14, 0.

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Two targeted sets of novel 1,5-diaryl-1-imidazole-4-carboxylic acids and carbohydrazides were designed and synthesized from their corresponding ester intermediates , which were prepared via cycloaddition of ethyl isocyanoacetate and diarylimidoyl chlorides . Evaluation of these new target scaffolds in the AlphaScreen HIV-1 IN-LEDGF/p75 inhibition assay identified seventeen compounds exceeding the pre-defined 50% inhibitory threshold at 100 µM concentration. Further evaluation of these compounds in the HIV-1 IN strand transfer assay at 100 μM showed that none of the compounds (with the exception of , , and , with marginal inhibitory percentages) were actively bound to the active site, indicating that they are selectively binding to the LEDGF/p75-binding pocket.

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Novel ethyl 2-(5-aryl-1H-imidazol-1-yl)-acetates 17 and propionates 18, together with their acetic acid 19 and acetohydrazide 20 derivatives, were designed and synthesized using TosMIC chemistry. Biological evaluation of these newly synthesized scaffolds in the HIV-1 Vpu- Host BST-2 ELISA assay identified seven hits (17a, 17b, 17c, 17g, 18a, 20f and 20g) with greater than 50% inhibitory activity. These hits were validated in the HIV-1 Vpu- Host BST-2 AlphaScreen™ and six of the seven compounds were found to have comparable percentage inhibitory activities to those of the ELISA assay.

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We describe here the synthesis of libraries of novel 1-subtituted-5-aryl-1H-imidazole, 5-aryl-4-tosyl-4,5-dihydro-1,3-oxazole and 5-aryl-1,3-oxazole fragments via microwave (MW)-assisted cycloaddition of para-toluenesulfonylmethyl isocyanide (TosMIC) to imines and aldehydes. The compounds obtained were biologically evaluated in an AlphaScreen HIV-1 IN-LEDGF/p75 inhibition assay with six imidazole-based compounds (16c, 16f, 17c, 17f, 20a and 20d) displaying more than 50% inhibition at 10 µM, with IC values ranging from 7.0 to 30.

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