Palladium Nanoparticles for the Deuteration and Tritiation of Benzylic Positions on Complex Molecules.

Palladium nanoparticles (PdNp) were revealed as an efficient hydrogen isotope exchange catalyst for the deuterium and tritium labeling of benzylic positions of complex molecules. A practical way to obtain small palladium nanoparticles and to apply them as a catalyst for hydrogen isotope exchange (HIE) is presented. Several model compounds and popular bioactive molecules were submitted to HIE reactions catalyzed by the PdNp.

Radiochemical Applications in Industry - A Journey through Time with RC Tritec.

Over the course of time, radioactive applications have changed from miracle cures to a material that is treated with caution in public perception. As a Swiss company, which has always been working with radioactive materials, RC Tritec is an interesting example how the applications in private industry have changed over the years: The company was originally a Ra-226 activated luminous paint manufacturer which managed to become a leader in the field of tritium labelling, the construction of manifolds for the handling of ionizing gases, source production and neutron imaging.

Unemployment and HIV mortality in the countries of the Organisation for Economic Co-operation and Development: 1981-2009.

Objectives: To determine an association between unemployment rates and human immunodeficiency virus (HIV) mortality in the Organisation for Economic Co-operation and Development (OECD).

Design: Multivariate regression analysis.

Participants: OECD member states.

Effects of economic downturns on child mortality: a global economic analysis, 1981-2010.

Objectives: To analyse how economic downturns affect child mortality both globally and among subgroups of countries of variable income levels.

Design: Retrospective observational study using economic data from the World Bank's Development Indicators and Global Development Finance (2013 edition). Child mortality data were sourced from the Institute for Health Metrics and Evaluation.

Economic downturns, universal health coverage, and cancer mortality in high-income and middle-income countries, 1990-2010: a longitudinal analysis.

Background: The global economic crisis has been associated with increased unemployment and reduced public-sector expenditure on health care (PEH). We estimated the effects of changes in unemployment and PEH on cancer mortality, and identified how universal health coverage (UHC) affected these relationships.

Methods: For this longitudinal analysis, we obtained data from the World Bank and WHO (1990-2010).

Effects of economic crises on population health outcomes in Latin America, 1981-2010: an ecological study.

Objectives: The relative health effects of changes in unemployment, inflation and gross domestic product (GDP) per capita on population health have not been assessed. We aimed to determine the effect of changes in these economic measures on mortality metrics across Latin America.

Design: Ecological study.

Changes in government spending on healthcare and population mortality in the European union, 1995-2010: a cross-sectional ecological study.

Objective: Economic measures such as unemployment and gross domestic product are correlated with changes in health outcomes. We aimed to examine the effects of changes in government healthcare spending, an increasingly important measure given constrained government budgets in several European Union countries.

Design: Multivariate regression analysis was used to assess the effect of changes in healthcare spending as a proportion of total government expenditure, government healthcare spending as a proportion of gross domestic product and government healthcare spending measured in purchasing power parity per capita, on five mortality indicators.

Unemployment, public-sector healthcare expenditure and colorectal cancer mortality in the European Union: 1990-2009.

Objectives: We examined the association between unemployment and government spending on healthcare with colorectal cancer mortality.

Methods: Retrospective observational study using data from the World Bank and WHO. Multivariate regression analysis was used, controlling for country-specific differences in infrastructure and demographics.

Unemployment and prostate cancer mortality in the OECD, 1990-2009.

The global economic downturn has been associated with increased unemployment in many countries. Insights into the impact of unemployment on specific health conditions remain limited. We determined the association between unemployment and prostate cancer mortality in members of the Organisation for Economic Co-operation and Development (OECD).

The effect of economic downturns on maternal mortality among pregnancies with abortive outcomes in 81 countries, 1981-2010.

Objective: To determine the association between economic downturns and abortion-related maternal mortality in multiple countries over 30 years.

Methods: In a retrospective study, WHO data were obtained for maternal deaths among pregnancies with abortive outcomes between January 1, 1981, and December 31, 2010. Economic data for the same period were obtained from The World Bank.

Enablers and Barriers in Implementing Integrated Care.

-The integration of medical and social care aims to address the fragmentation in patient services observed in many health care systems. Increasing rates of chronic disease and multimorbidity have drawn attention to the often significant reforms necessary to address these problems. In this article we discuss how integration may be achieved.

Unemployment, public-sector health care expenditure and HIV mortality: An analysis of 74 countries, 1981-2009.

Background: The global economic downturn has been associated with increased unemployment and reduced public-sector expenditure on health care (PSEH). We determined the association between unemployment, PSEH and HIV mortality.

Methods: Data were obtained from the World Bank and the World Health Organisation (1981-2009).

Government health care spending and child mortality.

Background: Government health care spending (GHS) is of increasing importance to child health. Our study determined the relationship between reductions in GHS and child mortality rates in high- and low-income countries.

Methods: The authors used comparative country-level data for 176 countries covering the years 1981 to 2010, obtained from the World Bank and the Institute for Health Metrics and Evaluation.

Unemployment, government healthcare spending, and cerebrovascular mortality, worldwide 1981-2009: an ecological study.

Background: The global economic downturn has been associated with unemployment rises, reduced health spending, and worsened population health. This has raised the question of how economic variations affect health outcomes.

Aim: We sought to determine the effect of changes in unemployment and government healthcare expenditure on cerebrovascular mortality globally.

Unemployment, public-sector health-care spending and breast cancer mortality in the European Union: 1990-2009.

Background: The global economic crisis has been associated with increased unemployment, reduced health-care spending and adverse health outcomes. Insights into the impact of economic variations on cancer mortality, however, remain limited.

Methods: We used multivariate regression analysis to assess how changes in unemployment and public-sector expenditure on health care (PSEH) varied with female breast cancer mortality in the 27 European Union member states from 1990 to 2009.

Safe use of electronic health records and health information technology systems: trust but verify.

Objectives: We will provide a context to health information technology systems (HIT) safety hazards discussions, describe how electronic health record-computer prescriber order entry (EHR-CPOE) simulation has already identified unrecognized hazards in HIT on a national scale, helping make EHR-CPOE systems safer, and we make the case for all stakeholders to leverage proven methods and teams in HIT performance verification.

Methods: A national poll of safety, quality improvement, and health-care administrative leaders identified health information technology safety as the hazard of greatest concern for 2013. Quality, HIT, and safety leaders are very concerned about technology performance risks as addressed in the Health Information Technology and Patient Safety report of the Institute of Medicine; and these are being addressed by the Office of the National Coordinator of HIT of the U.