Fabrication of a Dual-Purpose Implant Surgical Guide.

While surgical guides have allowed for more highly accurate immediate implant placement in the esthetic zone, only a few techniques have been described to predictably position an immediate implant provisional. Even fewer techniques have addressed repositioning a patient's extracted tooth for use as the interim implant restoration. This article describes a workflow for the fabrication of a dual-purpose surgical guide that allows for guidance of implant placement as well as repositioning of a decoronated tooth that will serve as a provisional.

Experimental studies of the transmission of light through low-coverage regular or random arrays of silica micropillars supported by a glass substrate.

The transmission of light through low-coverage regular and random arrays of glass-supported silica micropillars of diameters 10-40 µm and height 10 µm is studied experimentally. Angle-resolved measurements of the transmitted intensity are performed at visible wavelengths by either a goniospectrophotometer or a multimodal imaging (Mueller) polarimetric microscope. It is demonstrated that for the regular arrays, the angle-resolved measurements are capable of resolving many of the densely packed diffraction orders that are expected for periodic structures of lattice constants 20-80 µm, but they also display features ("halos" and fringes) that are due to the scattering and guiding of light in individual micropillars or in the supporting glass slides.

Digital histology with Mueller microscopy: how to mitigate an impact of tissue cut thickness fluctuations.

Mueller microscopy studies of fixed unstained histological cuts of human skin models were combined with an analysis of experimental data within the framework of differential Mueller matrix (MM) formalism. A custom-built Mueller polarimetric microscope was used in transmission configuration for the optical measurements of skin tissue model adjacent cuts of various nominal thicknesses (5 to 30  μm). The maps of both depolarization and polarization parameters were calculated from the corresponding microscopic MM images by applying a logarithmic Mueller matrix decomposition (LMMD) pixelwise.

Investigation of dental cone-beam CT pixel data and a modified method for conversion to Hounsfield unit (HU).

Objectives: To investigate the relationship in dental cone-beam CT (CBCT) between the manufacturer-reported image pixel data and a modified conversion to CT number densities in Hounsfield unit (HU).

Methods: A standardized CT phantom was imaged using typical clinical parameters on CBCT from three manufacturers (Carestream 9300, Carestream Health, Rochester, NY; J Morita 3D Accutomo, J. Morita Mfg.

Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation.

Background: Inheritance of the human ε4 allele of the apolipoprotein (apo) E gene (APOE) significantly increases the risk of developing Alzheimer's disease (AD), in addition to adversely influencing clinical outcomes of other neurologic diseases. While apoE isoforms differentially interact with amyloid β (Aβ), a pleiotropic neurotoxin key to AD etiology, more recent work has focused on immune regulation in AD pathogenesis and on the mechanisms of innate immunomodulatory effects associated with inheritance of different APOE alleles. APOE genotype modulates expression of proximal genes including APOC1, which encodes a small apolipoprotein that is associated with Aβ plaques.

Effect of hepatitis C virus (HCV) genotype on HCV and HIV-1 disease.

The relationship between hepatitis C virus (HCV) genotype and HCV and human immunodeficiency virus (HIV) type 1 disease is not well defined. The present study analyzed data from a cohort of 207 HIV-1-infected and 126 HIV-1-uninfected children and adolescents with hemophilia who enrolled in the Hemophilia Growth and Development Study and were followed for 7 years. The mean HCV RNA level was higher in the participants in the HCV genotype 1 group than in the participants the HCV non-genotype 1 group, among both the HIV-1-infected (difference, +0.

Concurrent cerebral american trypanosomiasis and toxoplasmosis in a patient with AIDS.

We report a case of concurrent cerebral infection with Trypanosoma cruzi and Toxoplasma gondii in a patient with acquired immunodeficiency syndrome (AIDS). A 22-year-old El Salvadoran man initially improved during receipt of antitoxoplasmosis therapy, but he had rapidly progressive hemiplegia. Magnetic resonance imaging showed an abnormal finding in the left internal capsule, and cytological analysis of cerebrospinal fluid revealed T.

Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6.

Objectives: We sought to determine if vitamin B6 therapy would reverse linezolid-associated cytopenias and/or peripheral neuropathy.

Patients And Methods: We have recently treated two patients with disseminated Mycobacterium abscessus infections with prolonged (> or =9 month) courses of linezolid. Both patients developed cytopenias related to linezolid, and one patient also developed peripheral neuropathy.