Comparison of MRI head motion indicators in 40,969 subjects informs neuroimaging study design.

Head motion during MRI compromises image quality for clinical assessments and research. Active motion reduction strategies are effective but rarely applied due to uncertainty in their value for a given study. The ability to anticipate motion based on group characteristics would aid effective neuroimaging study design.

Parkinson's Disease Risk Variant rs9638616 is Non-Specifically Associated with Altered Brain Structure and Function.

Background: A genome-wide association study (GWAS) variant associated with Parkinson's disease (PD) risk in Asians, rs9638616, was recently reported, and maps to WBSCR17/GALNT17, which is involved in synaptic transmission and neurite development.

Objective: To test the association of the rs9638616 T allele with imaging-derived measures of brain microstructure and function.

Methods: We analyzed 3-Tesla MRI and genotyping data from 116 early PD patients (aged 66.