A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

RAS is a common driver of cancer that was considered undruggable for decades. Recent advances have enabled the development of RAS inhibitors, but the efficacy of these inhibitors remains limited by resistance. Here, we developed a pan-RAS inhibitor, ADT-007, that binds nucleotide-free RAS to block GTP activation of effector interactions and MAPK/AKT signaling, resulting in mitotic arrest and apoptosis.

Ultrahigh-Resolution K-Edge Imaging of Coronary Arteries With Prototype Deep-Silicon Photon-Counting CT: Initial Results in Phantoms.

Background Photon-counting CT (PCCT) represents a recent advancement in CT, offering improved spatial resolution and spectral separability. By using multiple adjustable energy bins, PCCT enables K-edge imaging, allowing mixed contrast agent distinction. Deep-silicon is a new type of photon-counting detector with different characteristics compared with cadmium photon-counting detectors.

Proceedings of the 17th International Meeting on Fully 3D Image Reconstruction in Radiology and Nuclear Medicine.

Contained within this volume are the scholarly contributions presented in both oral and poster formats at Fully3D 2023: The 17th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine. This conference convened from July 16-21, 2023, at Stony Brook University in New York. For ease of reference, all papers are organized alphabetically according to the last names of the primary authors.

Cardiac-induced motion of the pancreas and its effect on image quality of ultrahigh-resolution CT.

Recent advancements in diagnostic CT detector technology have made it possible to resolve anatomical features smaller than 20 LP/cm, referred to as ultra-high-resolution (UHR) CT. Subtle biological motions that did not affect standard-resolution (SR) CT may not be neglected in UHR. This study aimed to quantify the cardiac-induced motion of the pancreas and simulate its impact on the image quality of UHR-CT.

Ultra-high-resolution spectral silicon-based photon-counting detector CT for coronary CT angiography: Initial results in a dynamic phantom.

Background: Recent improvements in CT detector technology have led to smaller detector pixels resolving frequencies beyond 20 lp/cm and enabled ultra-high-resolution CT. Silicon-based photon-counting detector (PCD) CT is one such technology that promises improved spatial and spectral resolution. However, when the detector pixel sizes are reduced, the impact of cardiac motion on CT images becomes more pronounced.

Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery.

Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.

Study Design: Prospective cohort.

Setting: Pediatric tertiary care facility.

Congenital cytomegalovirus (CMV) for the pediatric otolaryngologist.

Cytomegalovirus (CMV) is a double-stranded DNA virus and a member of the herpesvirus family. It is the most common congenital viral infection. For symptomatic infections, symptoms can vary widely but tends to have a predilection for the central nervous system and for the reticuloendothelial system.

Molecular dynamics simulation for PBR pebble tracking simulation via a random walk approach using Monte Carlo simulation.

Using a Monte Carlo (MC) simulation, random walks were used for pebble tracking in a two-dimensional geometry in the presence of a biased gravity field. We investigated the effect of viscosity damping in the presence of random Gaussian fluctuations. The particle tracks were generated by Molecular Dynamics (MD) simulation for a Pebble Bed Reactor.