Publications by authors named "Thomas W Campbell"
Article Synopsis
- This study focuses on understanding how mRNA-based vaccines, specifically mRNA-1273, generate immune responses by examining the antibody epitope profiles in response to the SARS-CoV-2 spike protein.
- Researchers analyzed serum samples from clinical trial participants who received the mRNA-1273 vaccine, both after the primary series and following a booster dose, to identify specific antibody responses.
- Findings revealed that while initial antibody signals decreased over time, they significantly increased again after a booster, and certain booster formulations, like variant-updated vaccines, resulted in stronger antibody responses compared to the original mRNA-1273 booster.
Rationale: Prognostic tools for aiding in the treatment of hospitalized COVID-19 patients could help improve outcome by identifying patients at higher or lower risk of severe disease. The study objective was to develop models to stratify patients by risk of severe outcomes during COVID-19 hospitalization using readily available information at hospital admission.
Methods: Hierarchical ensemble classification models were trained on a set of 229 patients hospitalized with COVID-19 to predict severe outcomes, including ICU admission, development of acute respiratory distress syndrome, or intubation, using easily attainable attributes including basic patient characteristics, vital signs at admission, and basic lab results collected at time of presentation.