Innate immunity for better or worse govern the allograft response.

Purpose Of Review: To update knowledge concerning the cause and consequences of the detrimental forms of innate immunity that inevitably occurs in peritransplant period tissue and cellular transplants. In addition, we review the information that a newly discovered, engraftment-promoting, and tolerance-inducing macrophage population is identified and characterized.

Recent Findings: The allograft response mounted by adaptive immune cells is shaped by innate immunity.