Publications by authors named "Thomas Ten Bokkel Huinink"
Retreatment with anti-tumor necrosis factor therapy in combination with an immunomodulator for recurrence of Crohn's disease after ileocecal resection results in prolonged continuation as compared to anti-tumor necrosis factor monotherapy.
Sebastiaan Ten Bokkel Huinink Evelien M J Beelen Thomas Ten Bokkel Huinink Frank Hoentjen Alexander G L Bodelier
Eur J Gastroenterol Hepatol
January 2023
Background: A considerable proportion of Crohn's disease patients that undergo ileocecal resection (ICR) have failed anti-tumor necrosis factor (TNF) therapy preoperatively. This study aimed to assess the effectiveness of retreatment of anti-TNF therapy in patients with postoperative recurrence.
Methods: A real-world cohort study was performed on Crohn's disease patients who underwent primary ICR after anti-TNF therapy failure, and who were retreated with anti-TNF therapy for postoperative symptomatic Crohn's disease.
Downstream Influence of Coronary Stenoses on Microcirculatory Remodeling: A Histopathology Study.
Arterioscler Thromb Vasc Biol
January 2020
Article Synopsis
- The study aimed to investigate if microcirculatory remodeling occurs downstream of coronary stenoses in humans, despite previous experimental findings suggesting it happens.
- Researchers analyzed heart tissue from 55 deceased patients, focusing on various microcirculatory parameters, including arteriolar and capillary density.
- Results showed no significant differences in microcirculatory structure between arteries with and without stenosis, concluding that noncritical stenoses do not lead to structural changes in the coronary microcirculation.