Publications by authors named "Thomas Tao-Min Huang"
Article Synopsis
- - A rare case of drug-induced thrombotic microangiopathy (DI-TMA) occurred in a 21-year-old woman after receiving BEP chemotherapy for a malignant ovarian germ cell tumor.
- - The patient initially had a pelvic mass diagnosed as an endodermal sinus tumor and developed symptoms like anemia and kidney injury after chemotherapy, leading to a DI-TMA diagnosis.
- - Following treatment with plasma exchange and discontinuation of chemotherapy, the patient remained disease-free for 17 months, highlighting the need for quick diagnosis and treatment of DI-TMA associated with chemotherapy.
Previous studies have explored the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in reducing cardiovascular events in type 2 diabetes. Here we show that GLP-1 RAs are associated with lower risks of mortality, major cardiovascular events (MACEs), and major adverse kidney events (MAKEs) in type 2 diabetes patients with acute kidney disease (AKD). Utilizing global data from the TriNetX database (2002/09/01-2022/12/01) and propensity score matching, we compare 7511 GLP-1 RAs users to non-users among 165,860 AKD patients.
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- * A structured approach called "KAMPS" focuses on monitoring kidney function, medication management, and patient advocacy to improve care for AKD patients, supported by a multidisciplinary team of healthcare professionals.
- * Although research on AKD is limited, potential treatments like ACE inhibitors and SGLT2 inhibitors show promise, highlighting the need for further studies to enhance prognosis and outcomes.
Background/purpose: Double-filtration plasmapheresis (DFPP) can be used to remove circulating pathogenic molecules. By reclaiming filtered albumin, DFPP reduces the need for albumin and plasma replacement. Large proteins, such as fibrinogen, are removed.
View Article and Find Full Text PDFImportance: Sodium-glucose cotransport protein 2 inhibitors (SGLT-2is) have demonstrated associations with positive kidney-related and cardiovascular outcomes in patients with type 2 diabetes. However, the association of SGLT-2is with outcomes among patients with type 2 diabetes and acute kidney disease (AKD) remains unclear.
Objective: To examine the long-term associations of SGLT-2is with mortality, major adverse kidney events (MAKEs), and major adverse cardiovascular events (MACEs) in patients with type 2 diabetes and AKD.
Plasma levels of angiopoietin-2 are increased in patients with chronic kidney disease (CKD). Moreover, mouse models of progressive kidney disease also demonstrate increased angiopoietin-2 in both plasmas and kidneys. The role of dysregulated angiopoietins in the progression of kidney disease has not been thoroughly investigated.
View Article and Find Full Text PDFClinical decisions regarding the appropriate timing of weaning off renal replacement therapy (RRT) in critically ill patients are complex and multifactorial. The aim of the current study was to identify which critical patients with acute kidney injury (AKI) may be more likely to be successfully weaned off RRT using consensus cluster analysis. In this study, critically ill patients who received RRT at three multicenter referral hospitals at several timepoints from August 2016 to July 2018 were enrolled.
View Article and Find Full Text PDFContext.—: Critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT) have a poor prognosis. Several urinary AKI biomarkers have been proposed to predict renal recovery, but with limited discriminatory ability.
View Article and Find Full Text PDFThe COVID-19 pandemic has caused multiple deaths worldwide. Since no specific therapies are currently available, treatment for critically ill patients with COVID-19 is supportive. The most severe patients need sustained life support for recovery.
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- The study focuses on the relationship between kidney issues and cancer treatment, exploring the use of renal biopsies in cancer patients experiencing renal complications.
- An analysis of 77 patients revealed significant findings, including risks of end-stage renal disease (ESRD) and mortality linked to specific kidney damage identified through biopsies.
- The research emphasizes the importance of renal biopsy for accurate diagnosis and treatment guidance and calls for greater collaboration between oncologists and nephrologists in managing cancer patients' kidney health.