Enhancement of the performance of a fiber-based frequency comb by referencing to an acetylene-stabilized fiber laser.

We demonstrate a significant improvement in the performance of a fiber-based frequency comb when a GPS-disciplined Rb clock is replaced with an acetylene-stabilized laser as the frequency reference. We have developed a compact, maintenance-free acetylene-stabilized fiber laser with a sub-kHz short-term linewidth and an Allan deviation below 3×10 for integration times above 1 s. Switching the comb reference from the Rb clock to the acetylene-stabilized laser improves both comb tooth linewidth and Allan deviation by about two orders of magnitude.

Long noncoding RNAs in normal and pathological pluripotency.

The striking similarities between pluripotent and cancer cells, such as immortality and increased stress resistance, have long been acknowledged. Numerous studies searched for and successfully identified common molecular players and pathways, thus providing an entirely new challenge and potential therapeutic angle by targeting cancer cells or a specific stem population of the tumor via pluripotency associated processes. However, these strategies have until now mainly been restricted to proteins.