Publications by authors named "Thomas Swaine"
Article Synopsis
- A 48-year-old man with poorly controlled HIV experienced severe human monkeypox (hMPXV) infection, leading to painful lesions and complications like Ludwig's angina after incomplete treatment with tecovirimat.
- He was treated with intravenous cidofovir (not officially approved for hMPXV), which resulted in significant improvement after the first dose; he received multiple doses and was discharged after 52 days.
- Cidofovir's use for hMPXV is limited to animal studies and a few documented cases, highlighting the urgent need for more research on its effectiveness and proper treatment protocols.
The cellular actin cytoskeleton presents a barrier that must be overcome by many viruses, and it has become increasingly apparent many viral species have developed a diverse repertoire of mechanisms to hijack cellular actin-regulating signalling pathways as part of their cell entry processes. The Rho family GTPase Cdc42 is appreciated as a key moderator of cellular actin dynamics, and the development of specific Cdc42-inhibiting agents has given us an unprecedented ability to investigate its individual role in signalling pathways. However, investigative use of said agents, and the subsequent characterisation of the role Cdc42 plays in viral entry processes has been lacking.
View Article and Find Full Text PDF