Publications by authors named "Thomas Soulier"

Article Synopsis
  • * A critical aspect of this research is accurately identifying cells in tissue samples, which can be difficult without clear cell membrane markers.
  • * To overcome this challenge, a new segmentation algorithm called ComSeg has been developed, which works directly with RNA data and shows superior performance over existing methods, making it a valuable tool for researchers.
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  • Patients with Fanconi anemia (FA) show chromosome instability, leading to exhaustion of hematopoietic stem cells and a higher risk of developing poor-prognosis myeloid leukemia.
  • A study involving 62 patients revealed unique mutations and structural variants that resemble BRCA-related cancers, with many patients showing chromosome 1q gain linked to MDM4 trisomy, which downregulates p53 signaling.
  • MDM4 triplication not only enhances the survival of FA stem cells but also promotes leukemia development, suggesting that targeting MDM4 could be a potential therapeutic strategy to disrupt this pathway.
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  • DDX41 germline mutations are a common cause of a type of cancer called myelodysplastic syndrome and acute myeloid leukemia (AML).
  • In a study of 191 patients with these mutations, it was found that most were older men with specific characteristics like low white blood cell counts and fewer genetic changes.
  • Patients with these mutations had higher chances of getting better with treatment (94% complete remission) and lived longer compared to those without the mutation, but their chances of relapse became similar after a few years.
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Intra-tumor heterogeneity portends poor outcome in many cancers. In AML, a higher number of drivers worsens prognosis. The Shannon Index is a robust metric of clonal heterogeneity that accounts for the number of clones, but also their relative abundance.

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Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes. Viral cell-cell transmission has been shown to play an important role in viral persistence allowing evasion from neutralizing antibodies. In contrast, the role of HCV cell-cell transmission for antiviral resistance is unknown.

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TLX1 is a homeodomain transcription factor generally associated with a favorable outcome in T-cell acute lymphoblastic leukemia (T-ALL). However, the molecular mechanisms of TLX1 deregulation remain unclear and various transcript levels in the absence of 10q24 abnormalities have been reported. A reproducible and accurate delineation of TLX1(+) T-ALL will be necessary for proper therapeutic stratification.

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