Publications by authors named "Thomas Sordel"
Planar patch-clamp is a two-dimensional variation of traditional patch-clamp. By contrast to classical glass micropipette, the seal quality of silicon patch-clamp chips (i.e.
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- Successful cell-on-chip microsystems rely on effectively controlling how cells interact with their surfaces.
- The study examined various materials for their impact on Chinese Hamster Ovary (CHO) cell growth and shape, including treated glasses and silicon forms, finding distinct behaviors from each substrate.
- Notably, the research identified that while cell adhesion and morphology didn't always correlate, UV/O(3) treatments on PDMS coatings significantly improved cell adhesion and promoted elongated cell shapes.
Obtaining high-throughput electrophysiological recordings is an ongoing challenge in ion channel biophysics and drug discovery. One particular area of development is the replacement of glass pipettes with planar devices in order to increase throughput. However, successful patch-clamp recordings depend on a surface coating which ideally should promote and stabilize giga-seal formation.
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