Publications by authors named "Thomas Signouret"
Article Synopsis
- A study examined the prevalence of PTSD among ICU survivors after being treated for COVID-19 compared to other causes of ICU admission, finding that 4.9% of patients in both groups had a presumptive diagnosis of PTSD six months later.
- After adjusting for factors like age and prior trauma, COVID-19 status alone was not linked to PTSD diagnosis, although female patients were more likely to exhibit PTSD symptoms.
- Patients treated for COVID-19 did report higher levels of specific PTSD symptoms like intrusion and avoidance when compared to those treated for other conditions, indicating different psychological impacts.
Background: The short-term and long-term consequences of the most frequent painful procedures performed in the ICU are unclear. This study aimed to identify the risk factors associated with pain-related discomfort perceived by critically ill patients during the whole ICU stay as self-reported by patients at the end of their ICU stay.
Methods: The study involved 34 ICUs.
Background And Aims: We reported the validation of the 18-item version of the 'Inconforts des Patients de REAnimation (IPREA)' questionnaire that includes 2 new items exploring feeling depressed and shortness of breath during an intensive care unit (ICU) stay.
Methods: The validation process was integrated in a multicenter, cluster-randomized, controlled, two-parallel group study built to assess the effectiveness of a tailored multicomponent program for reducing self-perceived discomfort in the ICU. All patients aged 18 years or older who survived an ICU stay of 3 calendar days or more were eligible for inclusion.
Tailored multicomponent program for discomfort reduction in critically ill patients may decrease post-traumatic stress disorder in general ICU survivors at 1 year.
Intensive Care Med
February 2019
Purpose: Reducing discomfort in the intensive care unit (ICU) should have a positive effect on long-term outcomes. This study assessed whether a tailored multicomponent program for discomfort reduction was effective in reducing post-traumatic stress disorder (PTSD) symptoms at 1 year in general ICU survivors.
Methods: This study is a prospective observational comparative effectiveness cohort study involving 30 ICUs.
Purpose: Critically ill patients are exposed to stressful conditions and experience several discomforts. The primary objective was to assess whether a tailored multicomponent program is effective for reducing self-perceived discomfort.
Methods: In a cluster-randomized two-arm parallel trial, 34 French adult intensive care units (ICUs) without planned interventions to reduce discomfort were randomized, 17 to the arm including a 6-month period of program implementation followed by a 6-month period without the program (experimental group), and 17 to the arm with an inversed sequence (control group).
Point-of-Care Versus Central Laboratory Measurements of Hemoglobin, Hematocrit, Glucose, Bicarbonate and Electrolytes: A Prospective Observational Study in Critically Ill Patients.
PLoS One
August 2017
Introduction: Rapid detection of abnormal biological values using point-of-care (POC) testing allows clinicians to promptly initiate therapy; however, there are concerns regarding the reliability of POC measurements. We investigated the agreement between the latest generation blood gas analyzer and central laboratory measurements of electrolytes, bicarbonate, hemoglobin, hematocrit, and glucose.
Methods: 314 paired samples were collected prospectively from 51 critically ill patients.
Objective: To assess the safety and efficacy of combining extracorporeal CO2 removal with continuous renal replacement therapy in patients presenting with acute respiratory distress syndrome and acute kidney injury.
Design: Prospective human observational study.
Settings: Patients received volume-controlled mechanical ventilation according to the acute respiratory distress syndrome net protocol.
Purpose: Takotsubo cardiomyopathy is characterized by the sudden onset of reversible left ventricular dysfunction. Associated refractory cardiogenic shock is a rare occurrence and may require extracorporeal membrane oxygenation (ECMO). We report a case of a patient who, following the inadvertent injection of 1 mg of epinephrine, presented with reverse Takotsubo cardiomyopathy and refractory cardiogenic shock that required the implementation of a percutaneous ECMO.
View Article and Find Full Text PDFObjective: To evaluate the incidence and risks factors of atrial fibrillation (AF).
Design: Prospective, observational study.
Setting: A surgical intensive care unit of a university hospital.
Objective: This prospective observational study was undertaken in order to assess pain experienced by intensive care unit patients at the time of extubation and to identify factors associated with pain of at least moderate intensity.
Design: Prospective observational study.
Setting: Intensive care unit at a university hospital.
Objective: To describe the clinical course and imaging findings in a young man who developed a spongiform leucoencephalopathy from heroin-vapour inhalation, and to discuss the treatments which may have contributed to the unexpected favourable outcome in this case.
Design: Case report.
Setting: Intensive care unit of a university teaching hospital.